Cas no 86060-82-4 (Fmoc-Lys(Z)-OH)

Fmoc-Lys(Z)-OH structure
Fmoc-Lys(Z)-OH structure
Product Name:Fmoc-Lys(Z)-OH
CAS No:86060-82-4
MF:C29H30N2O6
MW:502.558308124542
MDL:MFCD00065662
CID:60938
PubChem ID:3013736
Update Time:2024-10-26

Fmoc-Lys(Z)-OH Chemical and Physical Properties

Names and Identifiers

    • Nepsilon-Fmoc-Nalpha-Cbz-L-Lysine
    • Fmoc-Lys(Z)-OH
    • Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nepsilon-carbobenzoxy-L-lysine
    • (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((benzyloxy)carbonyl)amino)hexanoic acid
    • (S)-6-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(((benzyloxy)carbonyl)amino)hexanoic acid
    • Fmoc-L-Lys(Z)-OH
    • FMOC-LYS(CBZ)-OH
    • FMOC-N-EPSILON-CBZ-L-LYSINE
    • H-Phe-OBzl?HCl
    • Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nε-benzyloxycarbonyl-L-lysine
    • Nα-Fmoc-Nε-benzyloxycarbonyl-L-lysine
    • Nα-Fmoc-Nε-Cbz-L-lysine
    • N
    • A-Fmoc-N
    • A-Z-L-lysine
    • Lysine derivative 4
    • PubChem19681
    • BDBM9851
    • KRULQRVJXQQPQH-SANMLTNESA-N
    • N(alpha)-fmoc-N(epsilon)-Z-L-lysine
    • FCH3605571
    • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-(phenylmethoxycarbonylamino)hexanoic acid
    • K537
    • AX8008602
    • AB0
    • N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine (ACI)
    • Fmoc-Lys(Z)-OH,98%
    • F11063
    • 86060-82-4
    • SCHEMBL178700
    • M03420
    • HY-W010782
    • N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine
    • N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-(benZyl-oxycarbonyl)-L-lysine (Fmoc-L-Lys(CbZ)-OH)
    • (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(benzyloxycarbonylamino)hexanoic acid
    • L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-
    • (2S)-6-{[(benzyloxy)carbonyl]amino}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid
    • AKOS016842978
    • EN300-1556196
    • Fmoc-Lys(Z)-OH, >=98.0% (HPLC)
    • DS-13760
    • J-300179
    • (2S)-6-{[(benzyloxy)carbonyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid
    • CHEMBL359477
    • Nalpha-(9-fluorenylmethoxycarbonyl)-Nepsilon-benzyloxycarbonyl-L-lysine
    • CS-W011498
    • N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((benzyloxy)carbonyl)-L-lysine
    • MFCD00065662
    • DTXSID60388457
    • (2S)-6-(benzyloxycarbonylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
    • MDL： MFCD00065662
    • Inchi： 1S/C29H30N2O6/c32-27(33)26(16-8-9-17-30-28(34)36-18-20-10-2-1-3-11-20)31-29(35)37-19-25-23-14-6-4-12-21(23)22-13-5-7-15-24(22)25/h1-7,10-15,25-26H,8-9,16-19H2,(H,30,34)(H,31,35)(H,32,33)/t26-/m0/s1
    • InChI Key： KRULQRVJXQQPQH-SANMLTNESA-N
    • SMILES： C(C1C2=CC=CC=C2C2C=CC=CC1=2)OC(=O)N[C@H](C(=O)O)CCCCNC(=O)OCC1C=CC=CC=1

Computed Properties

  • Exact Mass: 502.21
  • Monoisotopic Mass: 502.21
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 37
  • Rotatable Bond Count: 13
  • Complexity: 733
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 4
  • XLogP3: 5
  • Topological Polar Surface Area: 114

Experimental Properties

  • Density: 1.2610
  • Melting Point: 110-120?°C
  • Boiling Point: 751.2°C at 760 mmHg
  • Flash Point: 408.1°C
  • Refractive Index: 1.603
  • PSA: 113.96000
  • LogP: 5.85680
  • Optical Activity: [α]20/D ?10±2°, c =?2% in DMF

Fmoc-Lys(Z)-OH Security Information

  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Safety Instruction： 22-24/25
  • FLUKA BRAND F CODES：10
  • Storage Condition：2-8°C

Fmoc-Lys(Z)-OH Pricemore >>

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Fmoc-Lys(Z)-OH Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran ,  Water ;  10 min, 0 °C; 4 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3
Reference
Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
Huhtiniemi, Tero; Suuronen, Tiina; Lahtela-Kakkonen, Maija; Bruijn, Tanja; Jaeaeskelaeinen, Sanna; et al, Bioorganic & Medicinal Chemistry, 2010, 18(15), 5616-5625

Production Method 2

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Acetone ,  Water
Reference
9-Fluorenylmethyl pentafluorophenyl carbonate as a useful reagent for the preparation of N-[(9-fluorenylmethoxy)carbonyl] amino acids and their pentafluorophenyl esters
Schon, Istvan; Kisfaludy, Lajos, Synthesis, 1986, (4), 303-5

Production Method 3

Reaction Conditions
Reference
Solid phase synthesis of substance P and its analogs employing 9-fluorenylmethoxycarbonyl amino acid active esters
Sivanandaiah, K. M.; Rangaraju, N. S., Indian Journal of Chemistry, 1986, (10), 1045-9

Production Method 4

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: 1,4-Dioxane ,  Water
Reference
Nε-[[2-(Trimethylsilyl)ethoxy]carbonyl] derivatives of tri-L-lysine and tetra-L-lysine as potential intermediates in the block polymer synthesis of macromolecular drug conjugates
Rosowsky, Andre; Wright, Joel E., Journal of Organic Chemistry, 1989, 54(23), 5551-8

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran ,  Water ;  10 min, 0 °C; 4 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3
Reference
Structure-Based Design of Pseudopeptidic Inhibitors for SIRT1 and SIRT2
Huhtiniemi, Tero; Salo, Heikki S.; Suuronen, Tiina; Poso, Antti; Salminen, Antero; et al, Journal of Medicinal Chemistry, 2011, 54(19), 6456-6468

Production Method 6

Reaction Conditions
1.1 Reagents: Dibromo[1,1′-oxybis[ethane]]magnesium Solvents: Dichloromethane
Reference
Mild, selective cleavage of amino acid and peptide β-(trimethylsilyl)ethoxymethyl (SEM) esters by magnesium bromide
Chen, Wei-Chuan; Vera, Matthew D.; Joullie, Madeleine M., Tetrahedron Letters, 1997, 38(23), 4025-4028

Production Method 7

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: 1,4-Dioxane ,  Water
1.2 Reagents: Hydrochloric acid Solvents: Water
Reference
Complexation of organic dyes by peptides built of lysine and glutamic acid amides
Mehlmann, Heinz; Olschewski, Daniel; Olschewski, Andrey; Feigel, Martin, Zeitschrift fuer Naturforschung, 2002, 57(3), 343-348

Production Method 8

Reaction Conditions
1.1 Reagents: Diisopropylethylamine Solvents: Tetrahydrofuran ,  Water ;  2 min, rt
1.2 1 h, rt
Reference
External-Radiation-Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors
Fu, Qunfeng; Li, Hongyu; Duan, Dongban; Wang, Changlun; Shen, Siyong; et al, Angewandte Chemie, 2020, 59(48), 21546-21552

Production Method 9

Reaction Conditions
1.1 Reagents: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride Solvents: Dimethylacetamide ,  Water ;  16 h, pH 9.4, rt
Reference
On-DNA Palladium-Catalyzed Hydrogenation-like Reaction Suitable for DNA-Encoded Library Synthesis
Priego, Julian; de Pedro Beato, Eduardo; Benavides, Jesus; Gironda-Martinez, Adrian; Gonzalez, Fernando; et al, Bioconjugate Chemistry, 2021, 32(1), 88-93

Production Method 10

Reaction Conditions
Reference
Pentapeptides as immunoregulators
, Federal Republic of Germany, , ,

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