Cas no 35661-40-6 (Fmoc-Phe-OH)
Fmoc-Phe-OH Chemical and Physical Properties
Names and Identifiers
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- Fmoc-L-phenylalanine
- N-Fmoc-L-phenylalanine
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid
- Fmoc-L-Phe-OH
- H-Phe-OtBu?HCl
- 9-fluorenylmethyloxycarbonyl-Phe-OH
- Fmoc-L-Phc-OH
- FMOC-L-PHE
- FMOC-PHE
- FMOC-PHENYLALANINE
- N-Fmoc-(S)-phenylalanine
- N-FMOC-L-PHE
- N-Fmoc-L-Phe-OH
- N-FMOC-PHE-OH
- Fmoc-Phe-OH
- N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine
- SJVFAHZPLIXNDH-QFIPXVFZSA-N
- (((9H-fluoren-9-yl)methoxy)carbonyl)-L-phenylalanine
- (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propanoic acid
- FmocPhe
- PubChem10029
- N-Fmoc-Phe-
- Z1123720064
- MFCD00037128
- SCHEMBL119455
- AKOS015837326
- DS-13761
- (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid
- N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-phenyl-L-alanine
- Fmoc-Phe-OH, 98%
- N-[(9H-fluoren-9ylmethyloxy)carbonyl]-L-phenylalanine
- (2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-phenylpropanoic acid
- NS00059304
- A822926
- (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylpropanoic acid
- (S)-N-FMOC-PHENYLALANINE
- 35661-40-6
- D77865
- AKOS010398582
- J-300209
- (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-phenylpropanoic acid
- 9fluorenylmethyloxycarbonyl-L-phenylalanine
- F0297
- Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
- NSC 334293
- CHEMBL357583
- BDBM50467857
- N-{[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}phenylalanine
- AC-16610
- A819517
- N-.alpha.-Fmoc-L-phenylalanine
- (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoic acid
- 286460-71-7
- EN300-81245
- HY-79131
- Q-101831
- N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PHENYLALANINE
- DTXSID30951314
- CS-W020026
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]phenylalanine #
- L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
- AM82158
- (s)-2-(((9h-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropanoic acid
- (s)-3-phenyl-2-(9h-fluoren-9-ylmethoxycarbonylamino)-propionic acid
- N-FMOC-L-phenylalanine-d8
- 1353853-39-0
- AC-24130
- M03370
- (2S)-2,3,3-trideuterio-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2,3,4,5,6-pentadeuteriophenyl)propanoic acid
- UTY9NU6ZEU
- Fmoc-L-phenylalanine,98%
- (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-phenylpropanoic acid
- N-9-Fluorenylmethoxycarbonyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine; NSC 334293
- DB-038142
- STL466186
-
- MDL： MFCD00037128
- Inchi： 1S/C24H21NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h1-13,21-22H,14-15H2,(H,25,28)(H,26,27)/t22-/m0/s1
- InChI Key： SJVFAHZPLIXNDH-QFIPXVFZSA-N
- SMILES： O(C(N[C@H](C(=O)O)CC1C=CC=CC=1)=O)CC1C2C=CC=CC=2C2=CC=CC=C12
- BRN： 3597808
Computed Properties
- Exact Mass: 387.14700
- Monoisotopic Mass: 387.147
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 29
- Rotatable Bond Count: 7
- Complexity: 551
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- XLogP3: 4.6
- Topological Polar Surface Area: 75.6
Experimental Properties
- Color/Form: powder
- Density: 1.2379 (rough estimate)
- Melting Point: 182.0 to 187.0 deg-C
- Boiling Point: 620.1°C at 760 mmHg
- Flash Point: 328.8°C
- Refractive Index: -39.5 ° (C=1, DMF)
- PSA: 75.63000
- LogP: 4.61190
- Specific Rotation: -38 o (c=1,DMF)
- Optical Activity: [α]20/D ?37°, c =?1 in DMF
- Solubility: Not determined
Fmoc-Phe-OH Security Information
- Signal Word：Warning
- Hazard Statement： H315-H319-H335-H413
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S22-S24/25
-
Hazardous Material Identification：
- Storage Condition：2-8°C
- Risk Phrases：R36/37/38
- Safety Term：S22;S24/25
Fmoc-Phe-OH Customs Data
- HS CODE：2924299090
- Customs Data：
China Customs Code:
2924299090Overview:
2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, packing
Summary:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Fmoc-Phe-OH Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | M03370-1g |
Fmoc-Phe-OH |
35661-40-6 | 99% | 1g |
￡10.00 | 2022-02-28 | |
| Fluorochem | M03370-100g |
Fmoc-Phe-OH |
35661-40-6 | 99% | 100g |
￡44.00 | 2022-02-28 | |
| BAI LING WEI Technology Co., Ltd. | 199851-1G |
Fmoc-L-phenylalanine, 98% |
35661-40-6 | 98% | 1G |
￥ 60 | 2022-04-26 | |
| BAI LING WEI Technology Co., Ltd. | 199851-5G |
Fmoc-L-phenylalanine, 98% |
35661-40-6 | 98% | 5G |
￥ 131 | 2022-04-26 | |
| BAI LING WEI Technology Co., Ltd. | 199851-25G |
Fmoc-L-phenylalanine, 98% |
35661-40-6 | 98% | 25G |
￥ 447 | 2022-04-26 | |
| TRC | F657570-5g |
N-FMOC-L-phenylalanine |
35661-40-6 | 5g |
$64.00 | 2023-05-18 | ||
| TRC | F657570-25 g |
N-FMOC-L-phenylalanine |
35661-40-6 | 25g |
$ 70.00 | 2022-01-08 | ||
| TRC | F657570-100 g |
N-FMOC-L-phenylalanine |
35661-40-6 | 100g |
$ 95.00 | 2022-01-08 | ||
| TRC | F657570-250 g |
N-FMOC-L-phenylalanine |
35661-40-6 | 250g |
$ 215.00 | 2022-01-08 | ||
| YAN FENG KE JI （ BEI JING ） Co., Ltd. | H68673-5g |
Fmoc-Phe-OH |
35661-40-6 | 98% | 5g |
￥60 | 2023-09-19 |
Fmoc-Phe-OH Suppliers
Audited Supplier
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Fmoc-Phe-OH Related Literature
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Subhasish Roy,Arindam Banerjee Soft Matter 2011 7 5300
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Santiago Grijalvo,Gustavo Puras,Jon Zárate,Ramon Pons,Jose Luis Pedraz,Ramon Eritja,David Díaz Díaz RSC Adv. 2016 6 39688
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Lawson K. Spare,Maria Menti,David G. Harman,Janice R. Aldrich-Wright,Christopher P. Gordon React. Chem. Eng. 2019 4 1309
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Patrick Hauske,Nicolette Mamant,Sonja Hasenbein,Sabrina Nickel,Christian Ottmann,Tim Clausen,Michael Ehrmann,Markus Kaiser Mol. BioSyst. 2009 5 980
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Xiao-Ding Xu,Liang Liang,Han Cheng,Xin-Hua Wang,Fa-Gang Jiang,Ren-Xi Zhuo,Xian-Zheng Zhang J. Mater. Chem. 2012 22 18164
Additional information on Fmoc-Phe-OH
Professional Introduction to Fmoc-Phe-OH (CAS No. 35661-40-6)
The compound Fmoc-Phe-OH, with the chemical name N-(9-fluorenylmethoxycarbonyl)-phenylalanine, is a critical intermediate in the field of peptide synthesis and pharmaceutical research. Its CAS number, 35661-40-6, uniquely identifies it within the vast repository of chemical substances. This introduction delves into the properties, applications, and recent advancements involving Fmoc-Phe-OH, emphasizing its significance in modern synthetic chemistry and drug development.
Fmoc-Phe-OH belongs to a class of compounds known as fluorenylmethyloxycarbonyl (Fmoc) protected amino acids. The Fmoc group is widely employed in solid-phase peptide synthesis (SPPS) due to its stability and ease of removal under mild acidic conditions. Phenylalanine, one of the 20 standard amino acids, is a non-polar, aliphatic amino acid that plays a crucial role in protein structure and function. The combination of these two components makes Fmoc-Phe-OH an indispensable tool for researchers aiming to construct complex peptide sequences.
The structural features of Fmoc-Phe-OH contribute to its versatility in peptide synthesis. The Fmoc group provides a protective cap for the amino group of phenylalanine, preventing unwanted side reactions during the synthesis process. This protection is typically removed at the end of each coupling step using an acidic deprotection agent, allowing for sequential addition of amino acids to build the desired peptide chain. The stability of the Fmoc group under basic conditions makes it particularly suitable for automated SPPS, which is the standard method for synthesizing peptides ranging from small peptides to large polypeptides like antibodies.
In recent years, advancements in peptide chemistry have highlighted the importance of high-purity intermediates like Fmoc-Phe-OH. The demand for synthetic peptides has surged due to their applications in drug discovery, diagnostics, and biotechnology. Researchers are continuously exploring new methodologies to improve peptide synthesis efficiency and yield. One notable development is the integration of continuous-flow chemistry into peptide synthesis processes, which offers advantages such as improved scalability and reproducibility. Fmoc-Phe-OH remains a cornerstone in these innovations, providing a reliable starting material for constructing complex peptide structures.
The role of Fmoc-Phe-OH extends beyond basic peptide synthesis into more specialized applications. For instance, it has been utilized in the development of peptidomimetics—synthetic molecules designed to mimic the biological activity of natural peptides but with enhanced stability and pharmacological properties. These peptidomimetics are being explored as potential therapeutic agents for various diseases, including cancer and neurodegenerative disorders. The ability to precisely modify peptide sequences using intermediates like Fmoc-Phe-OH is pivotal in this endeavor.
Recent studies have also demonstrated the utility of Fmoc-Phe-OH in solid-phase microextraction (SPME) techniques, where it serves as a derivatization agent for analyzing small molecules in environmental and biological samples. This application leverages the chemical properties of the Fmoc group to enhance the sensitivity and selectivity of analytical methods. Such innovations underscore the broad utility of compounds like Fmoc-Phe-OH across multiple scientific disciplines.
The pharmaceutical industry has witnessed significant interest in peptides as therapeutic agents due to their high specificity and low toxicity profiles. Many FDA-approved drugs are either peptides or peptidomimetics derived from peptide sequences. The synthesis of these complex molecules relies heavily on high-quality intermediates like Fmoc-Phe-OH. As drug development continues to evolve, particularly with the rise of biologics and targeted therapies, the demand for reliable peptide synthesis tools will only grow.
In conclusion, Fmoc-Phe-OH (CAS No. 35661-40-6) is a vital compound in modern chemical biology and pharmaceutical research. Its unique properties make it an essential intermediate for constructing complex peptides and peptidomimetics, which are critical for drug development and diagnostic applications. The ongoing advancements in synthetic chemistry and analytical techniques continue to highlight its importance, ensuring that Fmoc-Phe-OH remains at the forefront of scientific innovation.
