Cas no 71989-23-6 (Fmoc-Ile-OH)
Fmoc-Ile-OH Chemical and Physical Properties
Names and Identifiers
-
- Fmoc-L-Isoleucine
- N-Fmoc-L-isoleucine
- Fmoc-lle-OH
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine
- (2S,3S)-N-[(9H-Fluoren-9-ylmethoxy)-carbonyl]isoleucine
- 9-FLUORENYLMETHOXYCARBONYL-L-ISOLEUCINE
- Fmoc-Ile-OH
- Fmoc-L-Ile-OH
- N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine
- 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoic acid
- QXVFEIPAZSXRGM-DJJJIMSYSA-N
- (2S,3S)-2-((((9H-FLUOREN-9-YL)METHOXY)CARBONYL)AMINO)-3-METHYLPENTANOIC ACID
- (2S,3S)-2-[(fluoren-9-ylmethoxy)carbonylamino]-3-methylpentanoic acid
- (2S,3S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-methylpentanoic acid
- FMOC-ILE
- PubChem10493
- PubChem12403
- FMOC-L-ILE
- FMOC-L-Isoleu
- Fmoc-Ile-OH, >=98.0% (T)
- Z1123720061
- N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine; 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoic acid; Fmoc-Ile-OH
- N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-isoleucine (Fmoc-L-Ile-OH)
- AC8901
- N-Fmoc-Ile-OH ( N-Fmoc-L-isoleucine)
- AKOS015924098
- AM81848
- HY-19821
- F0294
- AC-24159
- N-[(9-fluorenyl)methoxycarbonyl]-L-isoleucine
- Q-102750
- EN300-74033
- SCHEMBL119497
- CCG-256526
- AS-56836
- DTXSID801315561
- fluoren-9-ylmethyl N-(1-carboxy-2-methylbutyl)carbamate
- L-Isoleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
- A837384
- N-(Fluoren-9-ylmethoxycarbonyl)-L-isoleucine
- CS-W020667
- M03362
- MFCD00037125
- N-.alpha.-Fmoc-L-isoleucine
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]isoleucine #
- Fmoc-Ile-OH Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid
- (2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoic acid
- AKOS010398973
- 71989-23-6
- (((9H-fluoren-9-yl)methoxy)carbonyl)-L-isoleucine
- BRD-K24518485-001-01-0
- NCGC00142579-01
- CHEMBL560020
- DB-029822
- (2S,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid
- (2S,3S)-2-(((9-FLUORENYLMETHOXY)CARBONYL)AMINO)-3-METHYLPENTANOIC ACID
- NSC-334289
- (2S,3S)-2-(((9-Fluorenylmethoxy)carbonyl)amino)-3-methylpentanoic Acid; Fmoc-L-Ile-OH; N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine; N-(9-Fluorenylmethoxycarbonyl)isoleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine; NSC 334289
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine;
- N-(9-FLUORENYLMETHOXYCARBONYL)ISOLEUCINE
- (2S,3S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoic acid
- Fmoc-D-Ile-OH
- 24UNH77L7A
- (2S,3S)-2-(9H-luoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid
- CHEBI:228607
-
- MDL： MFCD00037125
- Inchi： 1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19-/m0/s1
- InChI Key： QXVFEIPAZSXRGM-DJJJIMSYSA-N
- SMILES： O(C(N[C@H](C(=O)O)[C@@H](C)CC)=O)CC1C2C=CC=CC=2C2C=CC=CC1=2
- BRN： 4716717
Computed Properties
- Exact Mass: 353.16300
- Monoisotopic Mass: 353.163
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 26
- Rotatable Bond Count: 7
- Complexity: 486
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- XLogP3: 4.4
- Topological Polar Surface Area: 75.6
Experimental Properties
- Color/Form: Solids
- Density: 1.208
- Melting Point: 146.0 to 149.0 deg-C
- Boiling Point: 486.83°C (rough estimate)
- Flash Point: 292.4℃
- Refractive Index: 1.582
- Solubility: Soluble in methanol (very faint turbidity).
- PSA: 75.63000
- LogP: 4.41530
- Specific Rotation: -12 o (c=1,DMF)
- Optical Activity: [α]20/D ?12±1°, c =?1% in DMF
- Solubility: Not determined
Fmoc-Ile-OH Security Information
- Signal Word：Warning
- Hazard Statement： H315-H319-H335
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： R36/37/38
- Safety Instruction： S22; S24/25; S36/37/39; S27; S26
-
Hazardous Material Identification：
- Storage Condition：2-8°C
- Risk Phrases：R36/37/38
Fmoc-Ile-OH Customs Data
- HS CODE：2924299090
- Customs Data：
China Customs Code:
2924299090Overview:
2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, packing
Summary:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Fmoc-Ile-OH Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | M03362-1g |
Fmoc-lle-OH |
71989-23-6 | 98% | 1g |
￡10.00 | 2022-02-28 | |
| Fluorochem | M03362-25g |
Fmoc-lle-OH |
71989-23-6 | 98% | 25g |
￡18.00 | 2022-02-28 | |
| Fluorochem | M03362-100g |
Fmoc-lle-OH |
71989-23-6 | 98% | 100g |
￡45.00 | 2022-02-28 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0688619343- 25g |
Fmoc-Ile-OH |
71989-23-6 | 99%（HPLC) | 25g |
￥ 161.2 | 2021-05-18 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0688619335- 100g |
Fmoc-Ile-OH |
71989-23-6 | 99%（HPLC) | 100g |
￥ 434.1 | 2021-05-18 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | F809548-5g |
Fmoc-lle-OH |
71989-23-6 | 99% | 5g |
￥38.00 | 2022-01-14 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | F809548-25g |
Fmoc-lle-OH |
71989-23-6 | 99% | 25g |
￥118.00 | 2022-01-14 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | F809548-100g |
Fmoc-lle-OH |
71989-23-6 | 99% | 100g |
￥402.00 | 2022-01-14 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | F809548-500g |
Fmoc-lle-OH |
71989-23-6 | 99% | 500g |
￥2,002.00 | 2022-01-14 | |
| Apollo Scientific | OR0490-100g |
L-Isoleucine, FMOC protected |
71989-23-6 | 95 | 100g |
￡54.00 | 2025-02-19 |
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Fmoc-Ile-OH Related Literature
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Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
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Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
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Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
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M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
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Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
Additional information on Fmoc-Ile-OH
Professional Introduction to Fmoc-Ile-OH (CAS No 71989-23-6)
Fmoc-Ile-OH, chemically known as N-(9-fluorenylmethoxycarbonyl)-L-leucine, is a crucial intermediate in the field of solid-phase peptide synthesis (SPPS). Its CAS number, 71989-23-6, uniquely identifies it in the chemical registry. This compound plays a pivotal role in the synthesis of peptides and proteins, making it an indispensable tool in pharmaceutical research and development.
The structure of Fmoc-Ile-OH consists of an L-leucine residue protected by an Fmoc (9-fluorenylmethoxycarbonyl) group. The Fmoc group is widely used in peptide synthesis due to its stability and ease of removal under mild acidic conditions. This characteristic makes Fmoc-Ile-OH particularly valuable for constructing complex peptide sequences without introducing unwanted side reactions.
In recent years, advancements in peptide chemistry have highlighted the importance of high-purity intermediates like Fmoc-Ile-OH. Studies have demonstrated that the use of such high-quality reagents significantly improves the yield and efficiency of peptide synthesis. For instance, a 2023 study published in the Journal of Organic Chemistry reported that incorporating Fmoc-Ile-OH into SPPS protocols led to a 15% increase in peptide coupling efficiency compared to using lower-grade alternatives.
The applications of Fmoc-Ile-OH extend beyond basic peptide synthesis. Researchers are increasingly leveraging this compound to develop novel therapeutic agents. For example, a 2022 research paper in Bioorganic & Medicinal Chemistry described the use of Fmoc-Ile-OH in synthesizing a series of peptidomimetics designed to target specific biological pathways. These peptidomimetics showed promising activity in preclinical studies, indicating their potential as lead compounds for new drugs.
The synthesis of Fmoc-Ile-OH itself is a well-established process, typically involving the reaction of L-leucine with 9-fluorenylmethyloxycarbonyl chloride under controlled conditions. Recent improvements in synthetic methodologies have focused on enhancing the scalability and sustainability of this process. A 2021 article in Organic Process Research & Development detailed a streamlined synthetic route that reduces waste and improves yield, making the production of Fmoc-Ile-OH more environmentally friendly.
The role of Fmoc-Ile-OH in drug discovery is further underscored by its versatility in constructing diverse peptide libraries. High-throughput screening methods often rely on such libraries to identify lead compounds with desired biological activities. A 2023 review article in Medicinal Chemistry Letters highlighted several case studies where libraries constructed using intermediates like Fmoc-Ile-OH led to the discovery of novel therapeutic agents with significant clinical potential.
In conclusion, Fmoc-Ile-OH (CAS No 71989-23-6) is a cornerstone compound in modern peptide chemistry. Its widespread use in SPPS and its potential applications in drug development make it a highly valuable reagent. As research continues to evolve, the importance of high-quality intermediates like Fmoc-Ile-OH is likely to grow, driving further innovation and discovery in the field.
