Production Method 1

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -40 °C; 30 min, -40 °C
1.2 -40 °C; 2 h, -40 °C → rt; 6 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  Water ;  acidified, rt

Reference

Dibenzo[b,d]furan derivatives as protein tyrosine phosphatase 1B inhibitors

, India, , ,

Production Method 2

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  -40 °C; 30 min, -40 °C
1.2 2 h, -40 °C → 28 °C; 6 h, 28 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents

Lakshminarayana, N.; Prasad, Y. Rajendra; Gharat, Laxmikant; Thomas, Abraham; Narayanan, Shridhar; et al, European Journal of Medicinal Chemistry, 2010, 45(9), 3709-3718

Production Method 3

100124-06-9

298-12-4

96706-46-6

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: 1,2,3,4-Tetrahydroquinoline Solvents: Acetonitrile ;  24 - 36 h, rt

Reference

Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid

Huang, He; Yu, Chenguang; Li, Xiangmin; Zhang, Yongqiang; Zhang, Yueteng; et al, Angewandte Chemie, 2017, 56(28), 8201-8205

Production Method 4

96706-46-6

Reaction Conditions

Reference

Conformationally restricted diamines as spacers for parallel β-sheet formation

Skar, Merete L.; Svendsen, John S., Tetrahedron, 1997, 53(51), 17425-17440

Production Method 5

96706-46-6

Reaction Conditions

Reference

4-Heterotricyclic substituted 1,4-dihydropyridines with a potent selective bradycardic effect

Rampa, A.; Chiarini, A.; Bisi, A.; Budriesi, R.; Valenti, P., Arzneimittel-Forschung, 1991, 41(7), 705-9

Production Method 6

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: sec-Butyllithium
1.2 -

Reference

Dibenzofuran

Aspin, Samuel J., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2015, , 1-3

Production Method 7

64102-19-8

96706-46-6

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Potassium ferricyanide Catalysts: Dipotassium osmate Solvents: Acetonitrile ,  Water ;  rt → 60 °C; 4 h, 60 °C
1.2 Reagents: Sodium sulfite Solvents: Water

Reference

An expedient osmium(VI)/K3Fe(CN)6-mediated selective oxidation of benzylic, allylic and propargylic alcohols

Fernandes, Rodney A.; Bethi, Venkati, RSC Advances, 2014, 4(76), 40561-40568

Production Method 8

65344-26-5

96706-46-6

Reaction Conditions

1.1 Reagents: Potassium methoxide ,  Hexamethyldisilane Catalysts: Magnesium triflate Solvents: Dimethylformamide ;  rt; 4 h, rt
1.2 Solvents: Water ;  rt

Reference

Potassium methoxide/disilane-mediated formylation of aryl iodides with DMF at room temperature

Wang, Haiyang; Tong, Xiaogang; Huo, Yanman; Tang, Jiaying; Xia, Chengfeng, Organic Chemistry Frontiers, 2020, 7(24), 4074-4079

Production Method 9

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: Butyllithium ;  -78 °C

Reference

Insights into the Morita-Baylis-Hillman reaction of isomeric dibenzofuran carbaldehydes: a theoretical and mass spectral study

Yempala, Thirumal; Davalgar, Vijay Darshan; Gayatri, Gaddamanugu; Sripadi, Prabhakar; Kantevari, Srinivas, RSC Advances, 2015, 5(120), 99133-99142

Production Method 10

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Heptane ;  0 °C; 30 min, -78 °C
1.2 -78 °C; -78 °C → rt; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Preparation of aromatic heterocyclic compounds, organic semiconductor materials, films, and semiconductor devices

, Japan, , ,

Production Method 11

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Heptane ;  0 °C; 30 min, -78 °C
1.2 -78 °C; -78 °C → rt; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

Aromatic heterocyclic compound, manufacturing method thereof, organic semiconductor material, and organic semiconductor device

, World Intellectual Property Organization, , ,

Production Method 12

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: sec-Butyllithium Solvents: Diethyl ether ,  Hexane ;  -65 °C; 30 min, rt; 1 h, rt
1.2 rt → -65 °C; -65 °C; -65 °C → rt; 2 h, rt

Reference

Aromatic amine derivative for organic electroluminescent device

, World Intellectual Property Organization, , ,

Production Method 13

132-64-9

96706-46-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  30 min, 5 °C; 1 h, 5 °C
1.2 20 min, rt
1.3 Reagents: Sodium chloride Solvents: Water ;  rt

Reference

Preparation of dibenzofuranylmethyl and benzodioxinylmethyl thioacetamides as well as analogs for use in the treatment of sleep disorders and related diseases

, World Intellectual Property Organization, , ,

Production Method 14

96706-46-6

Reaction Conditions

Reference

Preparation of dibenzofuranylmethyl and benzodioxinylmethyl thioacetamides as well as analogs for use in the treatment of sleep disorders and related diseases

, European Patent Organization, , ,

Production Method 15

132-64-9

96706-46-6

172606-11-0

172606-07-4

172606-09-6

Reaction Conditions

1.1 Reagents: sec-Butyllithium Solvents: Diethyl ether ,  Hexane ,  Cyclohexane
1.2 Reagents: sec-Butyllithium
1.3 -

Reference

One-pot synthesis of dissymmetrical 4,6-disubstituted dibenzofurans

Jean, Fabienne; Melnyk, Oleg; Tartar, Andre, Tetrahedron Letters, 1995, 36(42), 7657-60

Dibenzob,dfuran-4-carbaldehyde Raw materials

• Dibenzofuran
• 4-Dibenzofuranmethanol
• 4-Iododibenzofuran
• Dibenzofuran-4-boronic acid
• 2-oxoacetic acid

Dibenzob,dfuran-4-carbaldehyde Preparation Products

• 4-Dibenzofurancarboxaldehyde, 3,6-dimethyl- (172606-11-0)
• 6-Methyl-4-dibenzofurancarboxaldehyde (172606-07-4)
• 4-Dibenzofurancarboxaldehyde, 3-methyl- (172606-09-6)
• Dibenzob,dfuran-4-carbaldehyde (96706-46-6)

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• 917745-07-4(Methyl, 3-benzofuranyloxo-)
• 1136-77-2(Dibenzofuran,4,6-dimethyl-)
• 17059-52-8(7-Methylbenzofuran)
• 648449-50-7(3-Methyl-1-benzofuran-5-carbaldehyde)
• 75293-82-2(BenzBIndeno1,2-EPyran-6-Carboxaldehyde)
• 64965-91-9(Benzofuran,5,7-dimethyl-)
• 95333-14-5(Benzofuran-7-carbaldehyde)
• 143883-36-7(3-Benzofurancarboxaldehyde,5-methyl-)
• 143883-37-8(3-Benzofurancarboxaldehyde,6-methyl-)
• 7320-53-8(Dibenzofuran, 4-methyl-)