Production Method 1

5398-69-6

93415-79-3

Reaction Conditions

1.1 Reagents: Sulfuric acid

Reference

Synthesis and chiroptical properties of bridged 2,2'-diaminobiphenyl derivatives

Seno, Kaoru; Hagishita, Sanji; Sato, Tomohiro; Kuriyama, Kaoru, Journal of the Chemical Society, 1984, (9), 2013-22

Production Method 2

5398-69-6

93415-79-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  20 h, reflux

Reference

Preparation of 3,4-dihydropyrrolo[4,3,2-de]isoquinolin-5(1H)-ones and analogs as poly(ADP-ribose) polymerase inhibitors

, World Intellectual Property Organization, , ,

Production Method 3

610-97-9

93415-79-3

112239-00-6

Reaction Conditions

1.1 Reagents: 5-Methyl-1,3-dinitro-1H-pyrazole Catalysts: Indium triflate Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  16 h, rt → 80 °C

Reference

From N-H Nitration to Controllable Aromatic Mononitration and Dinitration-The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent

Yang, Tao; Li, Xiaoqian; Deng, Shuang; Qi, Xiaotian ; Cong, Hengjiang ; et al, JACS Au, 2022, 2(9), 2152-2161

Production Method 4

5398-69-6

93415-79-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  12 h, reflux

Reference

Preparation of bicyclic compounds as melatonin receptor agonists for treatment and prevention of sleep disorders

, World Intellectual Property Organization, , ,

Production Method 5

5398-69-6

93415-79-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  48 h, reflux

Reference

5-Nitroisocoumarins from tandem Castro-Stephens coupling-6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles

Woon, Esther C. Y.; Dhami, Archana; Mahon, Mary F.; Threadgill, Michael D., Tetrahedron, 2006, 62(20), 4829-4837

Production Method 6

603-11-2

93415-79-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Mercuric acetate Solvents: Water
1.2 Reagents: Sodium hydroxide ,  Iodine Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Methanol

Reference

A new synthesis of 'push-pull' naphthalenes by condensation of nitro-2-methylbenzoate esters with dimethylacetamide dimethyl acetal

Wong, See-Mun; Shah, Bhavini; Shah, Priyal; Butt, Ian C.; Woon, Esther C. Y.; et al, Tetrahedron Letters, 2002, 43(12), 2299-2302

Production Method 7

93415-79-3

Reaction Conditions

Reference

5-Nitroisocoumarins from tandem Castro-Stephens coupling-6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3-nitrobenzoates with electrophiles. [Erratum to document cited in CA145:103504]

Woon, Esther C. Y.; Dhami, Archana; Mahon, Mary F.; Threadgill, Michael D., Tetrahedron, 2007, 63(19),

Production Method 8

88-67-5

93415-79-3

112239-00-6

Reaction Conditions

1.1 Reagents: Nitric acid Catalysts: Sulfuric acid Solvents: Water ;  10 min, 0 °C; 15 min, 0 °C; 0 °C → 23 °C; 30 min, 23 °C; 23 °C → 130 °C; 1 h, 130 °C; 130 °C → rt
1.2 Reagents: Potassium iodide Catalysts: Sulfuric acid Solvents: Water ;  rt; 1 h, 100 °C
1.3 Catalysts: Sulfuric acid Solvents: Water ;  overnight, reflux; reflux → rt
1.4 Reagents: Sodium bicarbonate Solvents: Water ;  pH 3; pH 5

Reference

A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids

Gonzalez-Gomez, Jose. C.; Ramirez, Nieves P.; Lana-Villarreal, Teresa; Bonete, Pedro, Organic & Biomolecular Chemistry, 2017, 15(45), 9680-9684

Methyl 2-iodo-3-nitrobenzoate Raw materials

• o-Iodobenzoic acid
• 2-Iodo-3-nitrobenzoic acid
• 3-Nitrophthalic acid
• Methyl 2-iodobenzoate

Methyl 2-iodo-3-nitrobenzoate Preparation Products

• Methyl 2-iodo-3-nitrobenzoate (93415-79-3)
• Methyl 2-iodo-5-nitrobenzoate (112239-00-6)

• 1. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 2. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 5. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Nitrobenzoic acids and derivatives

• 89976-27-2(methyl 4-iodo-3-nitro-benzoate)
• 5398-69-6(2-Iodo-3-nitrobenzoic acid)
• 57362-77-3(Ethyl 4-iodo-3-nitrobenzoate)
• 112239-00-6(Methyl 2-iodo-5-nitrobenzoate)
• 479526-11-9(2-Iodo-benzoic acid 4-nitro-benzyl ester)
• 835916-53-5(Benzoic acid, 2-iodo-5-nitro-, ethyl ester)
• 19230-50-3(2-Iodo-5-nitrobenzoic acid)
• 499157-32-3(Benzoic acid, 4-iodo-3-nitro-, 1,1-dimethylethyl ester)
• 479215-18-4(2-Iodo-benzoic acid 3-nitro-benzyl ester)
• 6326-42-7(2-Iodo-4-nitro-benzoic Acid Methyl Ester)