Cas no 88-67-5 (o-Iodobenzoic acid)

o-Iodobenzoic acid is a versatile organic compound that serves as a valuable intermediate in the production of various pharmaceuticals and agrochemicals. Its key advantages include high reactivity, excellent solubility properties, and compatibility with diverse catalysts, making it an ideal precursor for multi-step synthesis reactions.
o-Iodobenzoic acid structure
o-Iodobenzoic acid structure
Product Name:o-Iodobenzoic acid
CAS No:88-67-5
MF:C7H5IO2
MW:248.017874479294
MDL:MFCD00002419
CID:34476
PubChem ID:6941
Update Time:2025-08-28

o-Iodobenzoic acid Chemical and Physical Properties

Names and Identifiers

    • 2-Iodobenzoic acid
    • O-IODOBENZOIC ACID
    • RARECHEM AL BO 0686
    • 2-IODO BENZONIC ACID
    • BENZOIC ACID, 2-IODO-
    • 'LGC' (4009)
    • IODOBENZOIC-2 ACID
    • 2-iodo-benzoicaciC
    • IBA
    • Iodobenzoic acid
    • Benzoic acid, o-iodo-
    • 2-iodo benzoic acid
    • Benzoic acid, iodo-
    • 2-Iodo-benzoic acid
    • Kyselina o-jodbenzoova
    • o-Jod-benzoesaeure
    • 2-Jod-benzoesaeure
    • C7H5IO2
    • Kyselina o-jodbenzoova [Czech]
    • CJNZAXGUTKBIHP-UHFFFAOYSA-N
    • 7Q00V80J7Q
    • sodium 2-iodobenzoate
    • Progona
    • NSC-3772
    • AKOS000119657
    • FT-0612665
    • 1321-07-9
    • Progonasyl
    • 2 Iodobenzoic acid
    • 2-(Iodo-(125)I)-benzoic acid
    • 2-IODOBENZOICACID
    • 2iodobenzoic acid
    • SCHEMBL40612
    • Q2535469
    • O-IODOBENZOIC ACID [MI]
    • W-100392
    • BRN 1861406
    • CCG-233561
    • I0053
    • Benzoic acid, 2-iodo
    • EN300-18255
    • STK256890
    • FT-0659004
    • 2-iodobenzoic-(125)I acid
    • CS-D0909
    • USAF EK-572
    • 2-Iodobenzoic acid, 98%
    • BS-4598
    • InChI=1/C7H5IO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10
    • 2-iodbenzoesyre
    • DTXSID6058976
    • CHEBI:287979
    • Ortho-iodobenzoic acid
    • HMS545E06
    • STR04823
    • AM20041295
    • A20364
    • AC-26054
    • EINECS 201-850-7
    • CHEMBL112424
    • SRI-10864-03
    • F0001-2188
    • WLN: QVR BI
    • AI3-01811
    • 2-Iodobenzoic acid, purum, >=95.0% (GC)
    • 2-Iodobenzoic acid, >=99%, purified by sublimation
    • 88-67-5
    • o-iodobenzoic-(125)I acid
    • SY001344
    • UNII-7Q00V80J7Q
    • NSC3772
    • NCGC00336388-01
    • NSC 3772
    • OISB
    • Kyselina o-jodbenzoova2Iodobenzoic acid
    • LS-37717
    • AA-506/30136037
    • MFCD00002419
    • Maybridge1_001326
    • HY-77433
    • ortho-iodo-sodium benzoate
    • Z57637028
    • ortho-iodo benzoic acid
    • 2-Iodobenzoic acid (ACI)
    • Benzoic acid, o-iodo- (6CI, 8CI)
    • 2-Carboxyphenyl iodide
    • DB-014123
    • NS00022866
    • GEO-04834
    • o-Iodobenzoic acid
    • MDL： MFCD00002419
    • Inchi： 1S/C7H5IO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)
    • InChI Key： CJNZAXGUTKBIHP-UHFFFAOYSA-N
    • SMILES： O=C(C1C(I)=CC=CC=1)O
    • BRN： 1861406

Computed Properties

  • Exact Mass: 247.93300
  • Monoisotopic Mass: 247.933422
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 136
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2.4
  • Topological Polar Surface Area: 37.3

Experimental Properties

  • Color/Form: White or slightly colored needle like crystals or crystalline powders
  • Density: 2.25
  • Melting Point: 160.0 to 164.0 deg-C
  • Boiling Point: 313.9℃/760mmHg
  • Flash Point: 313.9 °C at 760 mmHg
  • Solubility: Soluble in dimethyl sulfoxide and methanol
  • Water Partition Coefficient: Slightly soluble
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents, strong bases.
  • PSA: 37.30000
  • LogP: 1.98940
  • Merck: 5030
  • Sensitiveness: Light Sensitive
  • pka: 2.85(at 25℃)
  • Solubility: Soluble in ethanol, ether and alkali solution, slightly soluble in water.

o-Iodobenzoic acid Security Information

  • Symbol: GHS05 GHS07
  • Prompt：warning
  • Signal Word：Danger
  • Hazard Statement： H302,H315,H318,H335
  • Warning Statement： P261,P280,P305+P351+P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 22-37/38-41
  • Safety Instruction： S26-S39-S24/25-S22
  • RTECS：DH2975000
  • Hazardous Material Identification： Xi
  • Risk Phrases：R22
  • HazardClass：IRRITANT, LIGHT SENSITIVE
  • TSCA：T
  • Storage Condition：Store at room temperature

o-Iodobenzoic acid Customs Data

  • HS CODE：4002191900
  • Customs Data：

    China Customs Code:

    4002191900

o-Iodobenzoic acid Pricemore >>

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o-Iodobenzoic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Triethylamine ,  Silver acetate ,  Iodine Catalysts: Iridium, di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopen… Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  18 h, 23 °C
Reference
IrIII-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds
Weis, Erik ; Johansson, Magnus J. ; Martin-Matute, Belen, Chemistry - A European Journal, 2020, 26(45), 10185-10190

Production Method 2

Reaction Conditions
1.1 Reagents: Potassium iodide
Reference
Waste-free chemistry of diazonium salts and benign separation of coupling products in solid salt reactions
Kaupp, Gerd; Herrmann, Andreas; Schmeyers, Jens, Chemistry - A European Journal, 2002, 8(6), 1395-1406

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium bisulfate Solvents: Toluene ;  10 h, 110 °C
Reference
Selective debenzylation of benzyl esters by silica-supported sodium hydrogen sulphate
Hu, Yan Wei; Zuo, Li; Ye, De Yong; Duan, Wen Hu, Chinese Chemical Letters, 2009, 20(10), 1157-1160

Production Method 4

Reaction Conditions
1.1 Reagents: Potassium iodide Solvents: Water ;  200 min, rt
Reference
Unusually Stable, Versatile, and Pure Arenediazonium Tosylates: Their Preparation, Structures, and Synthetic Applicability
Filimonov, Victor D.; Trusova, Marina; Postnikov, Pavel; Krasnokutskaya, Elena A.; Lee, Young Min; et al, Organic Letters, 2008, 10(18), 3961-3964

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium trimethylsilanolate Solvents: Tetrahydrofuran ;  18 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3, rt
Reference
Scope and limitations of sodium and potassium trimethylsilanolate as reagents for conversion of esters to carboxylic acids
Lovric, Marija; Cepanec, Ivica; Litvic, Mladen; Bartolincic, Anamarija; Vinkovic, Vladimir, Croatica Chemica Acta, 2007, 80(1), 109-115

Production Method 6

Reaction Conditions
1.1 Reagents: tert-Butyl hydroperoxide ,  Sodium hydroxide Solvents: Water ;  2 - 4 h, 90 °C
Reference
Halogen-free oxidation of aryl ketones and benzyl nitrile derivatives to corresponding carboxylic acids by using NaOH/ TBHP in aqueous medium
Jaiswal, Arvind Kumar; Kushawaha, Ajay Kishor; Pandey, Shubham; Kumar, Abhishek; Sashidhara, Koneni V., Tetrahedron, 2023, 136,

Production Method 7

Reaction Conditions
1.1 Reagents: L-Ascorbic acid ,  Tripotassium phosphate Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ,  Water ;  1 h, rt
1.2 Reagents: Potassium bisulfate Solvents: Water ;  pH 2 - 3, rt
Reference
Desyl and Phenacyl as Versatile, Photocatalytically Cleavable Protecting Groups: A Classic Approach in a Different (Visible) Light
Speckmeier, Elisabeth; Zeitler, Kirsten, ACS Catalysis, 2017, 7(10), 6821-6826

Production Method 8

Reaction Conditions
1.1 Reagents: Potassium iodide
Reference
About iodine benzoic acid and single derivatives of the same
Wachter, Wilhelm, Berichte der Deutschen Chemischen Gesellschaft, 1893, 26, 1744-1745

Production Method 9

Reaction Conditions
1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Catalysts: Tetrabutylammonium bromide Solvents: Acetone ,  Dichloromethane ,  Water ;  24 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt
Reference
Palladium Supported on Silk Fibroin for Suzuki-Miyaura Cross-Coupling Reactions
Rizzo, Giorgio ; Albano, Gianluigi ; Lo Presti, Marco ; Milella, Antonella ; Omenetto, Fiorenzo G. ; et al, European Journal of Organic Chemistry, 2020, 2020(45), 6992-6996

Production Method 10

Reaction Conditions
1.1 Catalysts: Alumina ,  Potassium fluoride
1.2 Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water
Reference
Potassium fluoride doped alumina: an effective reagent for ester hydrolysis under solvent free conditions
Kabalka, George W.; Wang, Lei; Pagni, Richard M., Green Chemistry, 2001, 3(5), 261-262

Production Method 11

Reaction Conditions
1.1 Reagents: Triethylamine ,  Silver acetate ,  Iodine Catalysts: Iridium, di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopen… Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  18 h, rt
Reference
Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters
Han, Ming-Liang; Chen, Jun-Jie; Xu, Hui; Huang, Zhi-Cong; Huang, Wei; et al, JACS Au, 2021, 1(11), 1877-1884

Production Method 12

Reaction Conditions
1.1 Reagents: Triethylamine ,  Silver acetate ,  Iodine Catalysts: Iridium, di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopen… Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  18 h, rt
Reference
Palladium-catalyzed decarbonylative Catellani reaction
Han, Ming-Liang; Chen, Jun-Jie; Xu, Hui; Huang, Zhi-Cong; Huang, Wei; et al, ChemRxiv, 2021, 1, 1-11

Production Method 13

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  18 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2
Reference
Gold-Catalysed Oxyarylation of Styrenes and Mono- and gem-Disubstituted Olefins Facilitated by an Iodine(III) Oxidant
Ball, Liam T.; Lloyd-Jones, Guy C.; Russell, Christopher A., Chemistry - A European Journal, 2012, 18(10), 2931-2937

Production Method 14

Reaction Conditions
1.1 Reagents: Morpholine, 4-methyl-, 4-oxide, hydrate (1:1) Catalysts: TPAP Solvents: Acetonitrile ;  20 min, rt
1.2 Reagents: Isopropanol ;  rt
Reference
TPAP-Catalyzed Direct Oxidation of Primary Alcohols to Carboxylic Acids through Stabilized Aldehyde Hydrates
Schmidt, Andrea-Katharina C.; Stark, Christian B. W., Organic Letters, 2011, 13(16), 4164-4167

Production Method 15

Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: Tetrahydrofuran ;  3 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1
Reference
Cleavage of tert-butyl benzoates with NaH in DMF: comments on the mechanism and a simple and safe alternative procedure
Filali, Emane; Lloyd-Jones, Guy C.; Sale, David A., Synlett, 2009, (2), 205-208

Production Method 16

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Water ;  2.5 h, 0 °C
1.2 Reagents: Sodium nitrite Solvents: Water ;  10 min, 0 °C
Reference
Synthesis of 1-hydroxy-1,2-benziodoxol-3(1H)-one-1-oxide (IBX) and the application in the synthesis of tazobactam
Xu, Wei-liang; Li, Yun-zheng; Zhang, Qing-shan; Zhu, He-sun, Jingxi Huagong, 2004, 21(4), 304-306

Production Method 17

Reaction Conditions
1.1 Reagents: Potassium hydroxide ,  Silver nitrate Solvents: Water ;  5 min, rt
1.2 1 h, 60 °C; 60 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified
Reference
Synthesis, structural characterization, and antimicrobial activity of novel ferrocene-N-acyl hydrazones designed by means of molecular simplification strategy Celebrating the 100th anniversary of the birth of Professor Paulo Freire
dos Santos Filho, Jose Mauricio; de Souza Castro, Marcos Venicius Batista, Journal of Organometallic Chemistry, 2022, 979,

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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:88-67-5)2-Iodobenzoic acid
Order Number:LE6011;LE2462595
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:48
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(CAS:88-67-5)2-Iodobenzoic acid
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Purity:99.9%
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(CAS:88-67-5)2-Iodobenzoic Acid
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Purity:98%
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o-Iodobenzoic acid Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR
GC-MS EI-B
GC-MS

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:88-67-5)2-Iodobenzoic acid
LE6011;LE2462595
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
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Suzhou Senfeida Chemical Co., Ltd
(CAS:88-67-5)2-Iodobenzoic acid
sfd2305
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
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