Production Method 1

32807-28-6

88496-70-2

Reaction Conditions

1.1 Reagents: NADP Catalysts: Iron oxide (Fe3O4) (supported on helical multi-walled carbon nanotubes) ,  Carbon ,  Aldo-keto reductase ;  8 h, 35 °C

Reference

Chemoenzymatic catalysis of tert-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate by aldo-keto reductase coupled with composite Fe3O4 nanozyme scaffold

Qiu, Shuai; et al, Chemical Engineering Science, 2022, 261,

Production Method 2

88496-70-2

Reaction Conditions

1.1 3 d, 28 °C

Reference

Lentinus strigellus: a new versatile stereoselective biocatalyst for the bioreduction of prochiral ketones

Barros-Filho, Bartholomeu A.; et al, Tetrahedron: Asymmetry, 2009, 20(9), 1057-1061

Production Method 3

10488-68-3

88496-70-2

7331-52-4

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  40 h, pH 6.7, 30 °C

Reference

Dual production of highly pure methyl (R)-4-chloro-3-hydroxybutyrate and (S)-3-hydroxy-γ-butyrolactone with Enterobacter sp.

Suzuki, Toshio; et al, Enzyme and Microbial Technology, 1998, 24, 13-20

Production Method 4

123-96-6

32807-28-6

88496-70-2

5978-70-1

Reaction Conditions

1.1 Reagents: NADH ,  Tris(hydroxymethyl)aminomethane hydrochloride ;  pH 7.5, rt; 24 h, 30 °C

Reference

Tandem Concurrent Processes: One-Pot Single-Catalyst Biohydrogen Transfer for the Simultaneous Preparation of Enantiopure Secondary Alcohols

Bisogno, Fabricio R.; et al, Journal of Organic Chemistry, 2009, 74(4), 1730-1732

Production Method 5

32807-28-6

88496-70-2

150966-86-2

Reaction Conditions

1.1 Catalysts: Alcohol dehydrogenase Solvents: Isopropanol ,  Water ;  4 h, pH 7.5, 30 °C
1.2 Catalysts: Halohydrin dehalogenase ;  44 h, pH 7.5, 30 °C

Reference

Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles

Schrittwieser, Joerg H.; et al, European Journal of Organic Chemistry, 2009, (14), 2293-2298

Production Method 6

32807-28-6

88496-70-2

Reaction Conditions

1.1 Catalysts: NADP-dependent alc. dehydrogenase Solvents: Water ;  24 h, pH 7.5, 30 °C

Reference

Ketone-alcohol hydrogen-transfer equilibria: Is the biooxidation of halohydrins blocked?

Bisogno, Fabricio R.; et al, Chemistry - A European Journal, 2010, 16(36), 11012-11019

Production Method 7

638-07-3

88496-70-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Ruthenium, [(1,2,5,6-η)-1,5-cyclooctadiene]bis[(1,2,3-η)-2-methyl-2-propenyl]- ,  3H-Dinaphtho[2,1-c:1′,2′-e]phosphepin, 4,4′-[(1R)-[1,1′-binaphthalene]-2,2′-diyl… Solvents: Methanol ;  24 h, 60 bar, 100 °C; 100 °C → rt

Reference

Synthesis and catalytic application of novel binaphthyl-derived phosphorous ligands

Junge, Kathrin; et al, ARKIVOC (Gainesville, 2007, (5), 50-66

Production Method 8

32807-28-6

88496-70-2

Reaction Conditions

Reference

Preparative microbiological reduction of β-oxo esters with Thermoanaerobium brockii

Seebach, Dieter; et al, Angewandte Chemie, 1984, 96(2), 155-6

Production Method 9

32807-28-6

88496-70-2

Reaction Conditions

1.1 Solvents: Water ;  3 d, rt

Reference

Highly enantioselective bioreduction of prochiral ketones by stem and germinated plant of Brassica oleracea variety italica

Mohammadi, Mehdi; et al, Biocatalysis and Biotransformation, 2011, 29(6), 328-336

Production Method 10

32807-28-6

88496-70-2

109462-42-2

Reaction Conditions

1.1 Reagents: Isopropanol Catalysts: Alcohol dehydrogenase Solvents: Water ;  4 h, pH 7.5, 30 °C
1.2 Reagents: MTO-Dowex SBR-LCNG Catalysts: Halohydrin dehalogenase ;  20 h, 30 °C

Reference

Shifting the equilibrium of a biocatalytic cascade synthesis to enantiopure epoxides using anion exchangers

Schrittwieser, Joerg H.; et al, Tetrahedron: Asymmetry, 2009, 20(4), 483-488

Production Method 11

88496-70-2

7331-52-4

Reaction Conditions

1.1 -
2.1 Reagents: Calcium carbonate Solvents: Water ;  24 h, pH 7.2, 30 °C

Reference

Dual production of highly pure methyl (R)-4-chloro-3-hydroxybutyrate and (S)-3-hydroxy-γ-butyrolactone with Enterobacter sp.

Suzuki, Toshio; et al, Enzyme and Microbial Technology, 1998, 24, 13-20

Production Method 12

111-13-7

88496-70-2

5978-70-1

Reaction Conditions

1.1 Reagents: NADH ,  Tris(hydroxymethyl)aminomethane hydrochloride ;  pH 7.5, rt; 24 h, 30 °C
2.1 Reagents: NADH ,  Tris(hydroxymethyl)aminomethane hydrochloride ;  pH 7.5, rt; 24 h, 30 °C

Reference

Tandem Concurrent Processes: One-Pot Single-Catalyst Biohydrogen Transfer for the Simultaneous Preparation of Enantiopure Secondary Alcohols

Bisogno, Fabricio R.; et al, Journal of Organic Chemistry, 2009, 74(4), 1730-1732

(R)-4-Chloro-3-hydroxybutyric Acid Methyl Ester Raw materials

• 2-Octanol
• ethyl 4-chloro-3-oxobutanoate
• Methyl 4-chloro-3-hydroxybutanoate
• Methyl 4-chloro-3-oxobutanoate
• 2-Octanone

(R)-4-Chloro-3-hydroxybutyric Acid Methyl Ester Preparation Products

• (S)-3-Hydroxy-γ-butyrolactone (7331-52-4)
• (R)-Octan-2-ol (5978-70-1)
• Butanoic acid, 4-cyano-3-hydroxy-, methyl ester, (3S)- (150966-86-2)
• (R)-4-Chloro-3-hydroxybutyric Acid Methyl Ester (88496-70-2)
• Oxiraneacetic acid, methyl ester, (R)- (109462-42-2)

• 1. An intermolecular C–C coupling reaction of iridium complexes?
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• 2. An ionic liquid-based synergistic extraction strategy for rare earths?
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• 3. An automatic determination of thoria in thoria-urania mixtures
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• 4. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
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• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 86728-99-6(Butanoic acid, 4-chloro-3-hydroxy-, octyl ester, (R)-)
• 828276-57-9(Butanoic acid, 4-chloro-3-hydroxy-, 1-methylpropyl ester)
• 10488-19-4(4-Chloro-3-Hydroxy Butanoic Ethyl Ester)
• 10488-69-4(Ethyl 4-chloro-3-hydroxybutanoate)
• 89693-37-8(Butanoic acid, 4-chloro-3-hydroxy-, 1-methylethyl ester)
• 86728-85-0(Ethyl (S)-4-chloro-3-hydroxybutyrate)
• 86728-93-0((S)-Methyl-4-chloro-3-hydroxybutyrate)
• 90866-33-4((R)-Ethyl 4-Chloro-3-hydroxybutanoate (~90%))
• 10488-68-3(Methyl 4-chloro-3-hydroxybutanoate)
• 100596-47-2(Butanoic acid, 4-chloro-3-hydroxy-, propyl ester)