Production Method 1

32807-28-6

150966-86-2

88496-70-2

Reaction Conditions

1.1 Catalysts: Alcohol dehydrogenase Solvents: Isopropanol ,  Water ;  4 h, pH 7.5, 30 °C
1.2 Catalysts: Halohydrin dehalogenase ;  44 h, pH 7.5, 30 °C

Reference

Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles

Schrittwieser, Joerg H.; et al, European Journal of Organic Chemistry, 2009, (14), 2293-2298

Butanoic acid, 4-cyano-3-hydroxy-, methyl ester, (3S)- Raw materials

• Methyl 4-chloro-3-oxobutanoate

Butanoic acid, 4-cyano-3-hydroxy-, methyl ester, (3S)- Preparation Products

• Butanoic acid, 4-cyano-3-hydroxy-, methyl ester, (3S)- (150966-86-2)
• (R)-4-Chloro-3-hydroxybutyric Acid Methyl Ester (88496-70-2)

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