Production Method 1

354-08-5

87189-16-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  0 °C; 0 °C → rt; 3 h, rt

Reference

Copper-catalysed difluorocarbene transfer enables modular synthesis

Zeng, Xin; et al, Nature Chemistry, 2023, 15(8), 1064-1073

Production Method 2

5122-94-1

667-27-6

87189-16-0

139219-68-4

Reaction Conditions

1.1 Reagents: Hydroquinone ,  Potassium carbonate Catalysts: Styrene ,  Dichlorobis(triphenylphosphine)palladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: 1,4-Dioxane ;  1 h, 80 °C

Reference

Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate

Feng, Zhang; et al, Organic Letters, 2016, 18(1), 44-47

Production Method 3

667-27-6

87189-16-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ;  0 °C; 0 °C → rt; 20 h, rt

Reference

Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Yuan, Kedong; et al, Chemical Science, 2021, 12(4), 1363-1367

Production Method 4

667-27-6

87189-16-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ;  rt

Reference

Wittig gem-difluoroolefination of aldehydes with difluoromethyltriphenylphosphonium bromide

Li, Qiang; et al, Journal of Fluorine Chemistry, 2014, 163, 38-41

Potassium Bromodifluoroacetate Raw materials

• Bromodifluoroacetic acid
• [1,1'-Biphenyl]-4-ylboronic acid
• ethyl 2-bromo-2,2-difluoroacetate

Potassium Bromodifluoroacetate Preparation Products

• 1,1'-Biphenyl, 4-(difluoromethyl)- (139219-68-4)
• Potassium Bromodifluoroacetate (87189-16-0)

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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids and derivatives Alpha-halocarboxylic acids

• 683-98-7(Methyl Bromodifluoroacetate)
• 354-08-5(Bromodifluoroacetic acid)
• 84349-27-9(Sodium bromodifluoroacetate)
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• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)