Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
Chemical Communications Pub Date: 2013-10-08 DOI: 10.1039/C3CC46560H
Abstract
Systematic exchange of amino acid residues of similar physicochemical properties maintains specific coiled-coil interaction between two heptad repeats of HIV-1 gp41, as well as the biological activity of related peptide fusion inhibitors. This exchangeability can greatly degenerate sequence space of peptides thus making ab initio design of coiled-coil interaction feasible.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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