An intramolecular tryptophan-condensation approach for peptide stapling?
Organic & Biomolecular Chemistry Pub Date: 2017-12-08 DOI: 10.1039/C7OB02667F
Abstract
Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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