Alpha-halocarboxylic acids
Alpha-halocarboxylic acids are a class of organic compounds containing both a carboxylic acid group (-COOH) and a halogen atom attached to the α-carbon (the carbon directly adjacent to the carboxyl group). These compounds play a significant role in various chemical processes due to their unique reactivity. They are commonly used as precursors for a wide range of organic syntheses, particularly in the pharmaceutical industry where they serve as intermediates in drug synthesis.
The halogen substituent can be chlorine, bromine, or iodine, each imparting different properties and reactivities. For example, chlorine-substituted alpha-halocarboxylic acids are more reactive towards nucleophiles than their brominated counterparts due to the lower electron-withdrawing effect of chlorine.
Additionally, these compounds have applications in polymer chemistry, where they can act as initiators or crosslinking agents. Their versatile nature makes them indispensable tools in organic synthesis and industrial processes.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2,3,3,3-Tetrafluoropropanoic Acid | 359-49-9 | C3H2F4O2 |
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Bromofluoroacetic Acid | 359-25-1 | C2H2BrFO2 |
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Dibromofluoroacetic acid | 353-99-1 | C2HBr2FO2 |
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Sodium trifluoroacetate | 2923-18-4 | C2F3NaO2 |
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Silver trifluoroacetate | 2966-50-9 | C2AgF3O2 |
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2-fluoropropanoic acid | 6087-13-4 | C3H5FO2 |
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3-Chlorotetrafluoropropionic acid | 661-82-5 | C3HClF4O2 |
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Sodium bromoacetate | 1068-52-6 | C2H2BrNaO2 |
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2,2-Dichloro-3,3,3-trifluoropropionic acid | 422-39-9 | C3HCl2F3O2 |
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(s)-2-chloropropionic acid | 28554-00-9 | C3H5ClO2 |
Related Literature
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1. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
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Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
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Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
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Yu Long,Bing Yuan,Jianrui Niu,Xin Tong,Jiantai Ma New J. Chem., 2015,39, 1179-1185
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