Production Method 1

667-27-6

84349-27-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  0 - 5 °C; < 10 °C; 25 °C; 3 h, 25 °C

Reference

A radical chlorodifluoromethylation protocol for late-stage difluoromethylation and its application to an oncology candidate

Meng, Depei ; et al, Cell Reports Physical Science, 2021, 2(4),

Production Method 2

667-27-6

84349-27-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  < 10 °C; 25 °C; 3 h, 25 °C

Reference

Electrochemical Difluoromethylation of Electron-rich Olefins

Luan, Shinan; et al, Organic Letters, 2023, 25(10), 1678-1682

Production Method 3

667-27-6

84349-27-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  0 °C → rt; 24 h, rt

Reference

Silver-Catalyzed C-H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes

Zhu, Xiao-Lei; et al, Organic Letters, 2020, 22(14), 5451-5455

Sodium bromodifluoroacetate Raw materials

• ethyl 2-bromo-2,2-difluoroacetate

Sodium bromodifluoroacetate Preparation Products

• Sodium bromodifluoroacetate (84349-27-9)

• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 3. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 4. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids and derivatives Alpha-halocarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic Halides

Introduction to Sodium bromodifluoroacetate (CAS No. 84349-27-9)

Sodium bromodifluoroacetate (CAS No. 84349-27-9) is a specialized organic compound that has garnered significant attention in the field of chemical and pharmaceutical research. This compound, characterized by its unique molecular structure, exhibits a range of properties that make it particularly useful in various scientific applications. The presence of both bromine and fluorine atoms in its structure imparts distinct reactivity and functionality, which are leveraged in multiple research domains.

The molecular formula of sodium bromodifluoroacetate is C₂HBrF₂O₃Na, reflecting its composition and the synergistic effects of its constituent elements. The compound's structure includes a difluoroacetate moiety, which is known for its role in biochemical transformations and metabolic studies. This feature makes it a valuable tool in understanding enzyme mechanisms and metabolic pathways, particularly those involving carboxylate group interactions.

In recent years, sodium bromodifluoroacetate has been explored for its potential applications in drug development. Its ability to act as a fluorinating agent has opened new avenues in medicinal chemistry, where fluorine-containing compounds are increasingly recognized for their enhanced bioavailability and metabolic stability. Research has demonstrated that incorporating fluorine atoms into drug molecules can significantly improve their pharmacokinetic properties, making them more effective in therapeutic settings.

One of the most compelling aspects of sodium bromodifluoroacetate is its role in synthetic chemistry. The compound serves as an intermediate in the synthesis of more complex molecules, enabling researchers to construct intricate structures with precision. Its reactivity towards nucleophiles and electrophiles allows for the facile introduction of functional groups, facilitating the development of novel synthetic routes.

The use of sodium bromodifluoroacetate in academic and industrial research has been further highlighted by its application in studying enzyme inhibition and activation. Its ability to mimic natural substrates or interfere with specific enzymatic reactions provides researchers with insights into the mechanisms of biological processes. This has been particularly valuable in the development of targeted therapies for various diseases.

In addition to its pharmaceutical applications, sodium bromodifluoroacetate has found utility in materials science. The compound's unique electronic properties make it suitable for use in advanced materials, such as liquid crystals and organic semiconductors. These materials are integral to the development of next-generation electronic devices, including displays and solar cells.

The environmental impact of using sodium bromodifluoroacetate is also a subject of interest. While it offers numerous benefits in research and industrial applications, ensuring its responsible handling and disposal is crucial to minimize any potential ecological risks. Efforts are ongoing to develop sustainable practices that maximize the utility of this compound while adhering to environmental regulations.

The future prospects for sodium bromodifluoroacetate are promising, with ongoing research uncovering new possibilities for its application. As our understanding of molecular interactions deepens, this compound is likely to play an even greater role in advancing scientific knowledge and technological innovation.

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