Production Method 1

586-37-8

854184-18-2

Reaction Conditions

1.1 Catalysts: Triphos ,  Borate(1-), tetrafluoro-, cobalt(2+) (2:1) Solvents: 2,2,2-Trifluoroethanol ;  15 min, rt
1.2 Reagents: Hydrogen ,  Ammonia ;  24 h, 40 bar, 120 °C
1.3 Reagents: Hydrochloric acid Solvents: Methanol ;  4 - 5 h, rt

Reference

Homogeneous cobalt-catalyzed reductive amination for synthesis of functionalized primary amines

Murugesan, Kathiravan; et al, Nature Communications, 2019, 10(1), 1-9

Production Method 2

586-37-8

854184-18-2

Reaction Conditions

1.1 Catalysts: Nickel tetrafluoroborate ,  Triphos Solvents: 2,2,2-Trifluoroethanol ;  15 min, rt
1.2 Reagents: Hydrogen ,  Ammonia ;  24 h, 50 bar, 120 °C; 120 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Diethyl ether ,  Methanol ;  4 - 5 h, rt

Reference

General and selective synthesis of primary amines using Ni-based homogeneous catalysts

Murugesan, Kathiravan; et al, Chemical Science, 2020, 11(17), 4332-4339

Production Method 3

854184-18-2

Reaction Conditions

1.1 Reagents: 3,5-Bis(1,1-dimethylethyl) 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Catalysts: 2482544-45-4 Solvents: Methylcyclohexane ,  tert-Butyl methyl ether ;  rt

Reference

Chiral Bronsted Acids Catalyze Asymmetric Additions to Substrates that Are Already Protonated: Highly Enantioselective Disulfonimide-Catalyzed Hantzsch Ester Reductions of NH-Imine Hydrochloride Salts

Wakchaure, Vijay N.; et al, Synlett, 2020, 31(17), 1707-1712

Production Method 4

586-37-8

854184-18-2

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonium hydroxide Catalysts: Cobalt (supported on N-doped amorphous carbonmaterial) Solvents: Water ;  20 h, 10 bar, 50 °C; 50 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether ;  rt

Reference

Co-Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions

Elfinger, Matthias; et al, ChemSusChem, 2021, 14(11), 2360-2366

Production Method 5

205701-99-1

854184-18-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  1 h, reflux; reflux → rt

Reference

Bioinspired Organocatalytic Aerobic C-H Oxidation of Amines with an ortho-Quinone Catalyst

Qin, Yan; et al, Organic Letters, 2015, 17(6), 1469-1472

Production Method 6

586-37-8

540-69-2

854184-18-2

Reaction Conditions

1.1 rt → 155 °C; 155 °C → 180 °C; 10 h, 180 - 185 °C; 185 °C → rt
2.1 Reagents: Hydrochloric acid Solvents: Water ;  1 h, reflux; reflux → rt

Reference

Bioinspired Organocatalytic Aerobic C-H Oxidation of Amines with an ortho-Quinone Catalyst

Qin, Yan; et al, Organic Letters, 2015, 17(6), 1469-1472

1-(3-Methoxyphenyl)ethylamine hydrochloride Raw materials

• 1-(3-methoxyphenyl)ethan-1-one
• Ammonium formate
• N-[1-(3-methoxy-phenyl)-ethyl]-formamide

1-(3-Methoxyphenyl)ethylamine hydrochloride Preparation Products

• 1-(3-Methoxyphenyl)ethylamine hydrochloride (854184-18-2)

• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 4. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

• 7441-28-3(Benzenemethanamine, 4-methoxy-a-(4-methoxyphenyl)-, hydrochloride)
• 5267-46-9((4-Methoxyphenyl)(phenyl)methanamine Hydrochloride)
• 574744-39-1((S)-1-(4-Methoxyphenyl)ethanamine hydrochloride)
• 97294-78-5(1-(3,5-dimethoxyphenyl)ethan-1-amine)
• 1167414-89-2((1R)-1-(3-methoxyphenyl)ethan-1-amine hydrochloride)
• 781580-43-6((1S)-1-(3,5-dimethoxyphenyl)ethan-1-amine)
• 62409-13-6(1-(3-Methoxyphenyl)ethanamine)
• 82796-69-8((S)-1-(3-Methoxyphenyl)ethylamine)
• 88196-70-7((R)-1-(3-Methoxyphenyl)ethanamine)
• 911373-69-8((R)-1-(4-Methoxyphenyl)ethanamine hydrochloride)