Production Method 1

52189-63-6

850793-25-8

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  rt → -15 °C; -15 °C; 1.5 h, -15 °C; 10 min, rt; rt → 0 °C
1.2 Reagents: Water ;  0 °C

Reference

Biaryl Ethers as Novel Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Key Mutant Viruses

Su, Dai-Shi; Lim, John J.; Tinney, Elizabeth; Wan, Bang-Lin; Young, Mary Beth; et al, Journal of Medicinal Chemistry, 2009, 52(22), 7163-7169

Production Method 2

202925-08-4

850793-25-8

Reaction Conditions

1.1 Reagents: Lithium hydroxide Catalysts: Copper(II) acetylacetonate ,  N1,N2-Bis(4-hydroxy-2,6-dimethylphenyl)ethanediamide ;  rt
1.2 Solvents: Dimethyl sulfoxide ,  Water ;  24 h, 130 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified, cooled

Reference

Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions

Xia, Shanghua; Gan, Lu; Wang, Kailiang; Li, Zheng; Ma, Dawei, Journal of the American Chemical Society, 2016, 138(41), 13493-13496

3-fluoro-5-methoxy-phenol Raw materials

• 1-Fluoro-3,5-dimethoxybenzene
• 3-Chloro-5-fluoroanisole

3-fluoro-5-methoxy-phenol Preparation Products

• 3-fluoro-5-methoxy-phenol (850793-25-8)

• 1. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 2. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Methoxyphenols
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 330-84-7(1-Fluoro-4-phenoxybenzene)
• 330-93-8(1-Fluoro-4-(4-fluorophenoxy)benzene)
• 1524-19-2(4-(4-Fluorophenoxy)phenol)
• 398-62-9(4-Fluoro-1,2-dimethoxybenzene)
• 93343-10-3(1,3-difluoro-5-methoxybenzene)
• 456-49-5(1-fluoro-3-methoxybenzene)
• 459-60-9(1-fluoro-4-methoxybenzene)
• 115144-40-6(3,4-Difluoroanisole)
• 167683-93-4(2-Fluoro-4-methoxyphenol)
• 52189-63-6(1-Fluoro-3,5-dimethoxybenzene)