Production Method 1

372-38-3

93343-10-3

Reaction Conditions

1.1 Solvents: Methanol ;  rt → 75 °C; 65 - 75 °C

Reference

Method for preparing 4-iodophenyl ether derivative

, China, , ,

Production Method 2

123843-65-2

93343-10-3

Reaction Conditions

1.1 Catalysts: 1,3-Bis(diphenylphosphino)propane ,  Bis[(1,2,5,6-η)-1,5-cyclooctadiene]di-μ-hydroxydirhodium Solvents: Toluene ;  5 min, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  12 h, 110 °C

Reference

Rh(I)-Catalyzed Decarboxylative Transformations of Arenecarboxylic Acids: Ligand- and Reagent-Controlled Selectivity toward Hydrodecarboxylation or Heck-Mizoroki Products

Sun, Zhong-Ming; Zhang, Jing; Zhao, Pinjing, Organic Letters, 2010, 12(5), 992-995

Production Method 3

2713-34-0

93343-10-3

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  18 h, 60 °C

Reference

Preparation of triazolopyridine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2

, World Intellectual Property Organization, , ,

Production Method 4

100-96-9

93343-10-3

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid
1.2 Reagents: Tetrafluoroboric acid ;  heated

Reference

Synthesis of 3,5-difluoro-4-iodoanisole

Huang, Suoyi; Lu, Haifeng; Lan, Dan; Lu, Changqing; Lian, Mengnan; et al, Huaxue Yanjiu Yu Yingyong, 2008, 20(5), 636-637

Production Method 5

93343-10-3

Reaction Conditions

Reference

Preparation of alkoxyfluorobenzenes

, Japan, , ,

Production Method 6

2713-34-0

93343-10-3

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  5 h, 40 °C

Reference

A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines

Alonso-Alija, Cristina; Michels, Martin; Peilstocker, Karen; Schirok, Hartmut, Tetrahedron Letters, 2004, 45(1), 95-98

Production Method 7

372-38-3

93343-10-3

Reaction Conditions

1.1 Solvents: Toluene ,  Tetrahydrofuran ;  10 h, 60 - 80 °C

Reference

Process for preparation of 3,5-difluoroanisole from 1,3,5-trifluorobenzene and sodium methoxide

, China, , ,

Production Method 8

2713-34-0

93343-10-3

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  18 h, 60 °C

Reference

Imidazopyrimidine compounds useful for the treatment of cancer and their preparation

, World Intellectual Property Organization, , ,

Production Method 9

363-81-5

93343-10-3

Reaction Conditions

1.1 Reagents: Copper ,  Sulfuric acid
1.2 -

Reference

An unexpected route to fluorinated anisoles

Takechi, Naoto; Fukai, Yasushi; Oka, Kazuyoshi; Huisgen, Rolf, Chemistry Letters, 1996, (1), 23-4

Production Method 10

2713-34-0

512-56-1

93343-10-3

Reaction Conditions

1.1 Reagents: Calcium hydroxide ;  2.3 h, 80 °C

Reference

A Mild Heteroatom (O-, N-, and S-) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH)2 Combination

Tang, Yu; Yu, Biao, Synthesis, 2022, 54(10), 2373-2390

Production Method 11

372-38-3

93343-10-3

Reaction Conditions

1.1 Reagents: Ammonia

Reference

Reaction of aromatic compounds with nucleophilic reagents in a liquid ammonia medium. IV. Nucleophilic and protophilic activity of methylate and hydroxyl anions in reactions with polyfluoroaromatic compounds

Shtark, A. A.; Chuikova, T. V.; Shteingarts, V. D., Zhurnal Organicheskoi Khimii, 1984, 20(5), 1055-63

Production Method 12

93343-10-3

Reaction Conditions

Reference

Preparation of fluorophenols from polyfluorobenzenes and sodium methoxide via fluoroanisoles

, Japan, , ,

1,3-difluoro-5-methoxybenzene Raw materials

• 3,5-Difluorophenol
• 2,4,6-Trifluoroaniline
• 1,3-Benzenediamine, 5-methoxy-
• 2,6-Difluoro-4-methoxybenzoic acid
• Trimethyl phosphate
• 1,3,5-Trifluorobenzene

1,3-difluoro-5-methoxybenzene Preparation Products

• 1,3-difluoro-5-methoxybenzene (93343-10-3)

• 1. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Anisoles
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

• 330-84-7(1-Fluoro-4-phenoxybenzene)
• 330-93-8(1-Fluoro-4-(4-fluorophenoxy)benzene)
• 886498-93-7(2,6-Difluoro-4-methoxyphenol)
• 1524-19-2(4-(4-Fluorophenoxy)phenol)
• 456-49-5(1-fluoro-3-methoxybenzene)
• 459-60-9(1-fluoro-4-methoxybenzene)
• 850793-25-8(3-fluoro-5-methoxy-phenol)
• 115144-40-6(3,4-Difluoroanisole)
• 52189-63-6(1-Fluoro-3,5-dimethoxybenzene)
• 203245-17-4(1,2,3-Trifluoro-5-methoxybenzene)