• 1. An amplified fluorescence detection of T4 polynucleotide kinase activity based on coupled exonuclease III reaction and a graphene oxide platform?
  Ni-Na Sun,Fengli Qu,Xiaobing Zhang,Shufang Zhang,Jinmao You Analyst, 2015,140, 1827-1831
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 3. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 4. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 5. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Anisoles
• Pharmaceutical and Biochemical Products Medicinal Building Blocks Fluorine containing Building Blocks
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Professional Introduction to 3-Chloro-5-fluoroanisole (CAS No. 202925-08-4)

3-Chloro-5-fluoroanisole, with the chemical formula C?H?ClF, is a fluorinated aromatic compound that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound serves as a crucial intermediate in the synthesis of various biologically active molecules, making it a subject of extensive study and application. The presence of both chlorine and fluorine substituents in its structure imparts unique electronic and steric properties, which are highly valuable for designing novel chemical entities with enhanced efficacy and selectivity.

The< strong>CAS number 202925-08-4 provides a unique identifier for this compound, ensuring precise classification and tracking in scientific literature and industrial applications. The anisole core, characterized by a methoxy group attached to a benzene ring, is a well-known scaffold in medicinal chemistry due to its versatility in drug design. The introduction of halogen atoms, particularly fluorine, has been widely recognized for its ability to modulate metabolic stability, lipophilicity, and binding affinity to biological targets.

Recent advancements in computational chemistry and molecular modeling have enabled researchers to predict the pharmacokinetic profiles of< strong>3-Chloro-5-fluoroanisole with greater accuracy. Studies have demonstrated that the fluorine atom can enhance the metabolic stability of drug candidates by resisting degradation pathways such as hydrolysis and oxidation. This property is particularly beneficial in the development of long-acting pharmaceuticals that require prolonged circulation in the bloodstream.

In addition to its role as a synthetic intermediate, 3-Chloro-5-fluoroanisole has been explored in the development of novel agrochemicals. The combination of chlorine and fluorine substituents in its structure contributes to its potent activity against various pests and pathogens. Research indicates that these substituents can improve the binding interactions between the compound and biological receptors, leading to more effective pest control solutions.

The< strong>fluorinated aromatic ring present in 3-Chloro-5-fluoroanisole is also of interest in materials science, where it is used to develop advanced polymers and liquid crystals with tailored properties. The electron-withdrawing nature of fluorine atoms can enhance the thermal stability and mechanical strength of these materials, making them suitable for high-performance applications.

One of the most compelling aspects of< strong>3-Chloro-5-fluoroanisole is its utility in constructing complex molecular architectures. Researchers have leveraged its reactivity to develop novel heterocyclic compounds that exhibit interesting biological activities. For instance, derivatives of this compound have shown promise as inhibitors of enzymes involved in cancer metabolism. The precise control over substitution patterns on the anisole ring allows for fine-tuning of pharmacological properties, enabling the design of highly specific therapeutic agents.

The< strong>synthetic pathways involving 3-Chloro-5-fluoroanisole are diverse and well-documented. Common methods include nucleophilic aromatic substitution reactions, cross-coupling reactions, and metal-catalyzed transformations. These synthetic strategies have been optimized to ensure high yields and purity, making the compound readily accessible for further derivatization.

In conclusion, 3-Chloro-5-fluoroanisole (CAS No. 202925-08-4) is a multifaceted compound with significant applications in pharmaceuticals, agrochemicals, and materials science. Its unique structural features make it an invaluable building block for designing innovative chemical entities with enhanced biological activity and material properties. As research continues to uncover new applications for this compound, its importance in advancing scientific discovery is likely to grow even further.

• 202925-07-3(3-Chloro-4-fluoroanisole)
• 452-09-5(4-Chloro-2-fluoro-1-methoxy-benzene)
• 2267-25-6(2-chloro-4-fluoro-1-methoxy-benzene)
• 501-29-1(4-Chloro-3-fluoroanisole)
• 289039-42-5(Benzene,1-chloro-3-ethoxy-5-fluoro-)
• 450-89-5(2-Chloro-5-fluoroanisole)
• 85983-24-0(ETHANOL, 2-[4-(3-CHLORO-5-FLUOROPHENOXY)PHENOXY]-)
• 202982-70-5(3-chloro-5-fluoro-phenol)
• 85983-51-3(BENZENE, 1-CHLORO-3-FLUORO-5-(4-METHOXYPHENOXY)-)
• 85983-52-4(BENZENE, 2-CHLORO-1-FLUORO-4-(4-METHOXYPHENOXY)-)