Alternative donor substrates for inverting and retaining glycosyltransferases?

Chemical Communications Pub Date: 2006-11-07 DOI: 10.1039/B614636H

Abstract

By the use of glycosyl donors containing aromatic leaving groups linked with opposite anomeric configurations compared to those of the natural donor substrates, an inverting (Cst II) and a retaining (LgtC) glycosyltransferase were found to catalyse glycosylation reactions of natural acceptor substrates in the presence of the corresponding nucleotide.

Graphical abstract: Alternative donor substrates for inverting and retaining glycosyltransferases
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