• 1. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 2. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 3. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
  J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143
• 4. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 5. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Halophenols Fluorophenols
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Professional Introduction to 3-chloro-5-fluoro-phenol (CAS No. 202982-70-5)

3-chloro-5-fluoro-phenol, with the chemical formula C?H?ClF, is a fluorinated aromatic compound that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound, identified by its CAS number 202982-70-5, exhibits unique structural and chemical properties that make it a valuable intermediate in the synthesis of various biologically active molecules.

The< strong>fluorineatom in the molecule imparts distinct electronic and steric effects, influencing its reactivity and potential applications. The< strong>chlorosubstituent further enhances its utility as a building block in organic synthesis. Recent studies have highlighted the compound's role in developing novel therapeutic agents, particularly in the area of anti-inflammatory and antimicrobial drugs.

In the realm of medicinal chemistry, 3-chloro-5-fluoro-phenol has been explored for its potential to act as a precursor in the synthesis of kinase inhibitors. Kinases are enzymes involved in numerous cellular processes, and their dysregulation is often associated with various diseases, including cancer. By incorporating fluorine atoms into kinase inhibitors, researchers aim to improve their metabolic stability and binding affinity. The< strong>chlorogroup can also serve as a handle for further functionalization, allowing for the creation of more complex molecular architectures.

Recent advancements in computational chemistry have enabled more precise predictions of the biological activity of< strong>3-chloro-5-fluoro-phenol. Molecular modeling studies suggest that this compound can interact with specific protein targets, making it a promising candidate for drug discovery. Additionally, the< strong>fluorine-containing moiety is known to enhance the lipophilicity of drug candidates, which is a critical factor in their oral bioavailability.

The agrochemical industry has also shown interest in< strong>3-chloro-5-fluoro-phenol. Its structural features make it a suitable candidate for developing novel pesticides and herbicides. Fluorinated compounds are known for their improved efficacy and environmental stability, which are crucial attributes for agricultural applications. Research is ongoing to identify derivatives of this compound that exhibit enhanced pesticidal activity while minimizing environmental impact.

Synthetic methodologies for preparing< strong>3-chloro-5-fluoro-phenol have been refined over the years, leading to more efficient and scalable production processes. Modern synthetic routes often involve palladium-catalyzed cross-coupling reactions, which allow for precise functionalization of the aromatic ring. These advances have made it possible to produce large quantities of the compound for industrial applications.

The safety profile of< strong>3-chloro-5-fluoro-phenol is another critical aspect that has been thoroughly investigated. While it is not classified as a hazardous material, proper handling procedures must be followed to ensure safe laboratory practices. Researchers emphasize the importance of using personal protective equipment (PPE) and working in well-ventilated areas when handling this compound.

In conclusion, 3-chloro-5-fluoro-phenol(CAS No. 202982-70-5) is a versatile compound with significant potential in pharmaceutical and agrochemical applications. Its unique structural features, combined with recent advancements in synthetic chemistry and computational biology, make it an attractive candidate for further research and development. As our understanding of its properties continues to grow, so too will its role in creating innovative solutions for human health and agricultural productivity.

• 186589-76-4(5-Chloro-2-fluorophenol)
• 863870-86-4(2-Chloro-3-fluorophenol)
• 186590-21-6(Phenol,5-chloro-2,3-difluoro-)
• 3827-49-4(2-Chloro-5-fluorophenol)
• 348-62-9(4-Chloro-2-fluorophenol)
• 2268-03-3(4-CHLORO-3,5-DIFLUOROPHENOL)
• 2613-23-2(3-Chloro-4-fluorophenol)
• 392-71-2(2,6-Dichloro-4-fluorophenol)
• 1996-41-4(2-chloro-4-fluoro-phenol)
• 348-60-7(4-Chloro-3-fluorophenol)