Production Method 1

111128-12-2

80382-23-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  4 h, reflux; reflux → rt
1.2 Reagents: Sodium bicarbonate ;  pH 7
2.1 Reagents: Potassium carbonate Solvents: Toluene ;  1 h
2.2 10 h, reflux; reflux → rt
2.3 Reagents: Water
3.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  6 h, reflux
3.2 Reagents: Hydrochloric acid Solvents: Toluene ,  Water ;  pH 2, 10 °C
4.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  < 30 °C; 5 h, 30 °C → 0 °C

Reference

Synthesis of loxoprofen sodium

Wu, Ronggui; et al, Zhongguo Yiyao Gongye Zazhi, 2015, 46(8), 806-808

Production Method 2

75-77-4

120-92-3

80382-23-6

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dimethylformamide ;  rt; rt → 90 °C; 16 h, 90 °C
2.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  rt → 60 °C; 6 h, 60 °C
3.1 Reagents: Sodium hydroxide Solvents: Water ;  2 h, 50 °C; 50 °C → rt
3.2 Reagents: Hydrochloric acid Solvents: Water ;  neutralized, rt

Reference

Synthesis of loxoprofen sodium

Feng, Jiao; et al, Huaxue Shiji, 2016, 38(1), 88-90

Production Method 3

99807-54-2

611-10-9

80382-23-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Toluene ;  reflux; 12 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3 - 4, rt
2.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  8 h, reflux
3.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  pH 7 - 8, rt; 3 h, rt

Reference

New synthetic method of loxoprofen sodium

Zhang, Xingxian; et al, Zhongguo Yaowu Huaxue Zazhi, 2010, 20(1), 25-28

Production Method 4

81762-92-7

80382-23-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  2 h, 50 °C; 50 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  neutralized, rt

Reference

Synthesis of loxoprofen sodium

Feng, Jiao; et al, Huaxue Shiji, 2016, 38(1), 88-90

Production Method 5

68767-14-6

80382-23-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  < 30 °C; 5 h, 30 °C → 0 °C

Reference

Synthesis of loxoprofen sodium

Wu, Ronggui; et al, Zhongguo Yiyao Gongye Zazhi, 2015, 46(8), 806-808

Production Method 6

1152440-23-7

80382-23-6

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  6 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Toluene ,  Water ;  pH 2, 10 °C
2.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  < 30 °C; 5 h, 30 °C → 0 °C

Reference

Synthesis of loxoprofen sodium

Wu, Ronggui; et al, Zhongguo Yiyao Gongye Zazhi, 2015, 46(8), 806-808

Production Method 7

1152440-23-7

80382-23-6

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  8 h, reflux
2.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  pH 7 - 8, rt; 3 h, rt

Reference

New synthetic method of loxoprofen sodium

Zhang, Xingxian; et al, Zhongguo Yaowu Huaxue Zazhi, 2010, 20(1), 25-28

Production Method 8

99807-54-2

19980-43-9

80382-23-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  rt → 60 °C; 6 h, 60 °C
2.1 Reagents: Sodium hydroxide Solvents: Water ;  2 h, 50 °C; 50 °C → rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  neutralized, rt

Reference

Synthesis of loxoprofen sodium

Feng, Jiao; et al, Huaxue Shiji, 2016, 38(1), 88-90

Production Method 9

111128-12-2

80382-23-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Water ;  0 - 5 °C; 6 h, 0 - 5 °C
2.1 Reagents: Potassium carbonate Solvents: Toluene ;  reflux; 12 h, reflux; reflux → rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3 - 4, rt
3.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  8 h, reflux
4.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  pH 7 - 8, rt; 3 h, rt

Reference

New synthetic method of loxoprofen sodium

Zhang, Xingxian; et al, Zhongguo Yaowu Huaxue Zazhi, 2010, 20(1), 25-28

Production Method 10

99807-54-2

611-10-9

80382-23-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Toluene ;  1 h
1.2 10 h, reflux; reflux → rt
1.3 Reagents: Water
2.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  6 h, reflux
2.2 Reagents: Hydrochloric acid Solvents: Toluene ,  Water ;  pH 2, 10 °C
3.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  < 30 °C; 5 h, 30 °C → 0 °C

Reference

Synthesis of loxoprofen sodium

Wu, Ronggui; et al, Zhongguo Yiyao Gongye Zazhi, 2015, 46(8), 806-808

Loxoprofen sodium Raw materials

• Chlorotrimethylsilane
• Loxoprofen
• 4-(Bromomethyl)-α-methyl-benzeneacetic Acid Methyl Ester
• 2-4-(Bromomethyl)phenylpropionic Acid
• Cyclopentanone
• Loxoprofen Ethoxy Carbonyl Methyl Ester
• 1-(Trimethylsiloxy)cyclopentene
• Loxoprofen Impurity 11
• ethyl 2-oxocyclopentane-1-carboxylate

Loxoprofen sodium Preparation Products

• Loxoprofen sodium (80382-23-6)

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• 4. Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters
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• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids Phenylpropanoic acids
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Comprehensive Overview of Loxoprofen Sodium (CAS No. 80382-23-6): Mechanism, Applications, and Market Trends

Loxoprofen sodium, a nonsteroidal anti-inflammatory drug (NSAID) with the CAS number 80382-23-6, is widely recognized for its analgesic and anti-inflammatory properties. As a derivative of propionic acid, it is particularly effective in managing pain associated with musculoskeletal disorders, such as osteoarthritis and rheumatoid arthritis. The compound's unique mechanism of action, which involves inhibition of cyclooxygenase (COX) enzymes, has made it a popular choice among clinicians and patients alike.

In recent years, the demand for Loxoprofen sodium has surged due to its rapid onset of action and favorable safety profile compared to other NSAIDs. Patients frequently search for terms like "Loxoprofen sodium side effects", "Loxoprofen sodium vs ibuprofen", and "Loxoprofen sodium dosage for back pain", reflecting growing interest in its therapeutic applications. Additionally, the rise of telemedicine has led to increased online queries about OTC availability of Loxoprofen sodium and its compatibility with other medications.

From a pharmacological perspective, Loxoprofen sodium (CAS 80382-23-6) exhibits selective COX-2 inhibition, reducing the risk of gastrointestinal complications commonly associated with traditional NSAIDs. This feature has positioned it as a preferred alternative for long-term pain management. Research trends also highlight investigations into its potential anti-cancer properties, though these studies remain in preliminary stages. The compound's chemical stability and solubility profile further contribute to its widespread use in pharmaceutical formulations.

The global market for Loxoprofen sodium is projected to grow steadily, driven by an aging population and increasing prevalence of chronic pain conditions. Manufacturers are focusing on sustained-release formulations and combination therapies to enhance patient compliance. Environmental concerns have also prompted innovations in green synthesis methods for CAS 80382-23-6, aligning with the pharmaceutical industry's sustainability goals.

In conclusion, Loxoprofen sodium (CAS 80382-23-6) represents a critical therapeutic agent in modern pain management. Its balanced efficacy and safety profile, coupled with ongoing research into expanded applications, ensure its continued relevance in both clinical practice and pharmaceutical development. As consumer awareness grows, so does the need for accurate, accessible information about this versatile compound.

• 68767-14-6(Loxoprofen)
• 878761-33-2(1-Phenyl-1-cyclopentanecarboxylic acid sodium salt)
• 68767-16-8(2-(4-((2-Oxocyclohexyl)methyl)phenyl)propanoic acid)
• 3900-93-4(2-Cyclopentyl-2-phenylacetic Acid)
• 77-55-4(1-phenylcyclopentane-1-carboxylic acid)
• 84409-29-0(3-oxo-1-phenylcyclopentanecarboxylic acid)
• 80789-75-9(1-(4-methylphenyl)cyclopentane-1-carboxylic acid)
• 648869-31-2(4-Oxo-2-m-tolyl-pentanoic acid)
• 4439-87-6(Benzeneacetic acid, a-(2-oxopropyl)-)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)