Cas no 1152440-23-7 (Loxoprofen Ethoxy Carbonyl Methyl Ester)

Loxoprofen Ethoxy Carbonyl Methyl Ester is a derivative of loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) known for its analgesic and anti-inflammatory properties. This esterified form enhances the compound's solubility and bioavailability, making it a valuable intermediate in pharmaceutical synthesis. Its ethoxy carbonyl methyl group improves stability and facilitates controlled release, optimizing therapeutic efficacy. The compound is particularly useful in formulations requiring prolonged action or targeted delivery. As a precursor, it offers versatility in drug development while maintaining the parent molecule's pharmacological profile. Its synthesis and application adhere to stringent quality standards, ensuring consistency for research and industrial use.
Loxoprofen Ethoxy Carbonyl Methyl Ester structure
1152440-23-7 structure
Product Name:Loxoprofen Ethoxy Carbonyl Methyl Ester
CAS No:1152440-23-7
MF:C19H24O5
MW:332.390866279602
CID:4670462
Update Time:2025-06-07

Loxoprofen Ethoxy Carbonyl Methyl Ester Chemical and Physical Properties

Names and Identifiers

    • Loxoprofen Ethoxy Carbonyl Methyl Ester
    • Methyl 4-[[1-(ethoxycarbonyl)-2-oxocyclopentyl]methyl]-α-methylbenzeneacetate (ACI)
    • Inchi： 1S/C19H24O5/c1-4-24-18(22)19(11-5-6-16(19)20)12-14-7-9-15(10-8-14)13(2)17(21)23-3/h7-10,13H,4-6,11-12H2,1-3H3
    • InChI Key： HJPYJGPAWARAIF-UHFFFAOYSA-N
    • SMILES： O=C(C(C)C1C=CC(CC2(CCCC2=O)C(OCC)=O)=CC=1)OC

Loxoprofen Ethoxy Carbonyl Methyl Ester Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
L472945-10mg
Loxoprofen Ethoxy Carbonyl Methyl Ester
 1152440-23-7
10mg
 $133.00 2023-05-18
TRC
L472945-50mg
Loxoprofen Ethoxy Carbonyl Methyl Ester
 1152440-23-7
50mg
 $563.00 2023-05-18
TRC
L472945-100mg
Loxoprofen Ethoxy Carbonyl Methyl Ester
 1152440-23-7
100mg
 $ 1200.00 2023-09-07

Loxoprofen Ethoxy Carbonyl Methyl Ester Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Toluene ;  1 h
1.2 10 h, reflux; reflux → rt
1.3 Reagents: Water
Reference
Synthesis of loxoprofen sodium
Wu, Ronggui; Li, Dajun; Wang, Chunling, Zhongguo Yiyao Gongye Zazhi, 2015, 46(8), 806-808

Production Method 2

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Toluene ;  reflux; 12 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3 - 4
Reference
Study on the synthesis of nonsteroidal anti-inflammatory drug loxoprofen sodium
Xu, Xin-liang; He, Kun-lun; Lu, Xin; Zhang, Xing-xian, Zhongguo Yaowu Huaxue Zazhi, 2014, 24(5), 380-383

Production Method 3

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Toluene ;  reflux; 12 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3 - 4, rt
Reference
New synthetic method of loxoprofen sodium
Zhang, Xingxian; Hu, Kebin; Zhou, Dunfeng; Lu, Xin, Zhongguo Yaowu Huaxue Zazhi, 2010, 20(1), 25-28

Loxoprofen Ethoxy Carbonyl Methyl Ester Raw materials

Loxoprofen Ethoxy Carbonyl Methyl Ester Preparation Products

Loxoprofen Ethoxy Carbonyl Methyl Ester Related Literature

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