Production Method 1

81762-92-7

Reaction Conditions

1.1 Catalysts: 2,2′-Bipyridine ,  Bis(1,5-cyclooctadiene)nickel Solvents: Toluene ;  18 h, rt

Reference

Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions

Chen, Hang; Chen, Dong-Huang; Huang, Pei-Qiang, Science China: Chemistry, 2020, 63(3), 370-376

Production Method 2

68767-14-6

81762-92-7

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  15 min, rt; rt → 0 °C
1.2 Reagents: Water

Reference

Amide-Ligand-Promoted Silver-Catalyzed C-H Fluorination via Radical/Polar Crossover

Yamashita, Kenji ; Fujiwara, Yuki; Hamashima, Yoshitaka, Journal of Organic Chemistry, 2023, 88(3), 1865-1874

Production Method 3

2056022-10-5

81762-92-7

Reaction Conditions

1.1 Reagents: Hexamethylphosphoramide ,  Trichlorosilane Solvents: Dichloromethane ;  15 min, 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Boryl Radical Activation of Benzylic C-OH Bond: Cross-Electrophile Coupling of Free Alcohols and CO2 via Photoredox Catalysis

Li, Wen-Duo; Wu, Yang; Li, Shi-Jun ; Jiang, Yi-Qian; Li, Yan-Lin; et al, Journal of the American Chemical Society, 2022, 144(19), 8551-8559

Production Method 4

99807-54-2

19980-43-9

81762-92-7

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  rt → 60 °C; 6 h, 60 °C

Reference

Synthesis of loxoprofen sodium

Feng, Jiao; Pan, He-lin; Yu, Yan-kun; Long, Zhong-zhu; Cai, Shui-hong, Huaxue Shiji, 2016, 38(1), 88-90

Loxoprofen Impurity 11 Raw materials

• Loxoprofen
• 4-(Bromomethyl)-α-methyl-benzeneacetic Acid Methyl Ester
• Methyl α-methyl-4-[(2-oxocyclopentylidene)methyl]benzeneacetate
• 1-(Trimethylsiloxy)cyclopentene

Loxoprofen Impurity 11 Preparation Products

• Loxoprofen Impurity 11 (81762-92-7)

• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
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• 3. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 4. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 5. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683

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