Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
Chemical Communications Pub Date: 2020-09-04 DOI: 10.1039/D0CC03319G
Abstract
The ester–amide exchange reaction enables spontaneous formation of prebiotic proto-peptides under mild conditions. However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages. Here, we demonstrate using deep eutectic solvents as a universal strategy to regulate the reaction pathways and promote the formation of amino acid-enriched oligomers with peptide backbones.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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