Production Method 1

23145-07-5

79002-39-4

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  12 h, reflux

Reference

Systematic structure-activity relationship (SAR) exploration of diarylmethane backbone and discovery of a highly potent novel uric acid transporter 1 (URAT1) inhibitor

Cai, Wenqing; Wu, Jingwei; Liu, Wei; Xie, Yafei; Liu, Yuqiang; et al, Molecules, 2018, 23(2), 252/1-252/38

Production Method 2

2677836-01-8

79002-39-4

Reaction Conditions

1.1 Catalysts: Grubbs second generation catalyst Solvents: Dichloromethane ;  6 h, reflux

Reference

Design and synthesis of C3-symmetric molecules containing oxepine and benzofuran moieties via Metathesis

Kotha, Sambasivarao; Solanke, Balaji. U.; Gupta, Naveen Kumar, Journal of Molecular Structure, 2021, 1244,

Production Method 3

1129-35-7

60770-65-2

79002-39-4

Reaction Conditions

1.1 Catalysts: Bis(1,5-cyclooctadiene)nickel ,  1,2-Bis(dicyclohexylphosphino)ethane Solvents: o-Xylene ;  24 h, 140 °C; 140 °C → rt
1.2 Reagents: Potassium hydroxide Solvents: Water ;  3 h, 50 °C

Reference

Nickel-catalyzed reversible functional group metathesis between aryl nitriles and aryl thioethers

Delcaillau, Tristan; Boehm, Philip; Morandi, Bill, ChemRxiv, 2020, 1, 1-8

Production Method 4

60770-67-4

1449521-05-4

79002-39-4

Reaction Conditions

1.1 Reagents: Sodium amide Catalysts: Cupric nitrate ,  4,4′-Dimethyl [2,2′-bipyridine]-4,4′-dicarboxylate Solvents: Dimethylformamide ;  20 h, 130 °C

Reference

Difluorocarbene-Based Cyanation of Aryl Iodides

Zhang, Yin-Xiang; Xiao, Xuan; Fu, Zhi-Hong; Lin, Jin-Hong; Guo, Yu; et al, Synlett, 2020, 31(7), 713-717

Production Method 5

23145-07-5

79002-39-4

Reaction Conditions

1.1 Solvents: N-Methyl-2-pyrrolidone ;  24 h, 200 °C

Reference

Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors

Wang, Yazhou; Huang, Wei; Xin, Minhang; Chen, Pan; Gui, Li; et al, Bioorganic & Medicinal Chemistry, 2017, 25(1), 75-83

Production Method 6

60770-65-2

79002-39-4

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Bis(1,5-cyclooctadiene)nickel ,  1,2-Bis(dicyclohexylphosphino)ethane Solvents: 1,4-Dioxane ;  16 h, 110 °C

Reference

Nickel-Catalyzed Cyanation of Aryl Thioethers

Delcaillau, Tristan; Woenckhaus-Alvarez, Adrian; Morandi, Bill, Organic Letters, 2021, 23(18), 7018-7022

Production Method 7

14874-70-5

2093284-34-3

3010-03-5

79002-39-4

Reaction Conditions

1.1 Reagents: tert-Butanol ,  Hexamethyldisilane Catalysts: Palladium diacetate Solvents: Tetrahydrofuran ;  48 h, 55 °C

Reference

Palladium-Catalyzed Cyanation of Arenediazonium Tetrafluoroborate Derivatives with 2-(Piperidin-1-yl)acetonitrile as the Cyano Source

Ahmad, Muhammad Siddique ; Shafiq, Zahid; Meguellati, Kamel, Synthesis, 2022, 54(13), 3077-3084

Production Method 8

623-26-7

23145-07-5

79002-39-4

Reaction Conditions

1.1 Reagents: Tris(trimethylsilyl)silane ,  Bromotrimethylsilane ,  1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: Nickel iodide (NiI2) ,  4,4′-Bis(1,1-dimethylethyl)-2,2′-bipyridine Solvents: Toluene ;  16 h, 50 °C

Reference

Photochemically Enabled, Ni-Catalyzed Cyanation of Aryl Halides

Yan, Yonggang; Sun, Jinjin; Li, Gang; Yang, Liu; Zhang, Wei; et al, Organic Letters, 2022, 24(12), 2271-2275

Production Method 9

183589-16-4

79002-39-4

Reaction Conditions

1.1 Catalysts: Chloro(η5-cyclopentadienyl)bis(triphenylphosphine)ruthenium Solvents: Pyridine ;  1 h, 90 °C

Reference

Cycloisomerization of aromatic homo- and bis-homopropargylic alcohols via catalytic Ru vinylidenes: formation of benzofurans and isochromenes

Varela-Fernandez, Alejandro; Gonzalez-Rodriguez, Carlos; Varela, Jesus A.; Castedo, Luis; Saa, Carlos, Organic Letters, 2009, 11(22), 5350-5353

1-Benzofuran-5-carbonitrile Raw materials

• 1,4-Dicyanobenzene
• Borate(1-),tetrafluoro-
• Benzonitrile, 3-(1E)-1-propen-1-yl-4-[(1E)-1-propen-1-yloxy]-
• Benzonitrile, 3-ethynyl-4-hydroxy-
• 5-iodo-1-benzofuran
• 5-bromo-1-benzofuran
• Methyl 4-cyanobenzoate
• 5-Benzofurandiazonium
• 1-Piperidineacetonitrile
• 5-(methylsulfanyl)-1-benzofuran
• 2,2-difluoro-2-triphenylphosphaniumylacetate

1-Benzofuran-5-carbonitrile Preparation Products

• 1-Benzofuran-5-carbonitrile (79002-39-4)

• 1. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 2. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 3. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 4. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 5. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofurans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans

• 29021-90-7(Dibenzo[b,d]furan-3-carbonitrile)
• 33763-36-9(Dibenzo[b,d]furan-3,7-dicarbonitrile)
• 7320-51-6(2-Methyldibenzofuran)
• 18441-43-5(5-Methylbenzofuran)
• 150612-64-9(5-Benzofurancarbonitrile,3-methyl-)
• 51412-72-7(4-Dibenzofurancarbonitrile)
• 1136-79-4(Dibenzofuran, 2,8-dimethyl-)
• 52951-09-4(1-benzofuran-7-carbonitrile)
• 17450-68-9(BENZOFURAN-6-CARBONITRILE)
• 95333-17-8(Benzofuran-4-carbonitrile)