An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?

Organic & Biomolecular Chemistry Pub Date: 2012-08-02 DOI: 10.1039/C2OB25913C

Abstract

We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host–guest complex with doxorubicin as evidenced by FRET experiments.

Graphical abstract: An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin
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