Production Method 1

128868-60-0

95333-17-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylacetamide ;  12 h, 140 °C

Reference

Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer and their preparation

, World Intellectual Property Organization, , ,

Production Method 2

128868-60-0

95333-17-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylacetamide ;  12 h, 140 °C

Reference

Naphthyridine derivatives as PRC2 inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

95333-17-8

Reaction Conditions

Reference

PRC2 inhibitors for use in treating blood disorders

, World Intellectual Property Organization, , ,

Production Method 4

95333-17-8

Reaction Conditions

Reference

Conformational analysis of organic carbonyl compounds. Part 4. A proton and carbon-13 nuclear magnetic resonance study of formyl and acetyl derivatives of benzo[b]furan

Benassi, Rois; Folli, Ugo; Iarossi, Dario; Schenetti, Luisa; Taddei, Ferdinando, Journal of the Chemical Society, 1984, (9), 1479-85

Production Method 5

128868-60-0

128851-73-0

95333-17-8

17450-68-9

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  18 h, 100 °C

Reference

Preparation of the pyrimidone compound and their application as the anticancer agents

, China, , ,

Production Method 6

128868-60-0

95333-17-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylacetamide ;  12 h, 140 °C

Reference

Preparation of imidazopyrimidine amines as Prc2(Polycomb Repressive Complex 2) inhibitors useful in the treatment of blood disorders

, World Intellectual Property Organization, , ,

Production Method 7

128868-60-0

95333-17-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylacetamide ;  12 h, 140 °C

Reference

Preparation of dihydrobenzofuranylmethylaminoimidazopyrimidine derivatives for use as PRC2 inhibitors

, World Intellectual Property Organization, , ,

Production Method 8

128868-60-0

95333-17-8

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  17 h, reflux; reflux → rt
1.2 Reagents: Ethylenediamine Solvents: Water ;  rt

Reference

Preparation of 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2c receptor agonists

, World Intellectual Property Organization, , ,

Production Method 9

128868-60-0

95333-17-8

Reaction Conditions

1.1 Reagents: 6-Bromobenzofuran Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  18 h, 100 °C

Reference

Preparation pyrimidine- or pyrazine-based compounds for treating EED protein and/or PRC2 protein complex related diseases

, China, , ,

Production Method 10

1392146-22-3

95333-17-8

Reaction Conditions

1.1 Reagents: Formaldehyde Solvents: Toluene ;  overnight, 100 °C
1.2 Solvents: Dimethylformamide ;  overnight, 140 °C
1.3 Reagents: Ammonia Solvents: Water

Reference

Preparation of moracin compounds and its application

, China, , ,

Production Method 11

128868-60-0

95333-17-8

Reaction Conditions

1.1 Reagents: 6-Bromobenzofuran Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  18 h, 100 °C

Reference

Pyridine or pyridazine cyclic compound and application thereof in preparing drugs for treating cancer diseases or disorders

, China, , ,

Production Method 12

406721-29-7

95333-17-8

Reaction Conditions

1.1 Reagents: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Solvents: Toluene ;  45 min, 80 °C; 20 h, rt; 1.25 h, 80 °C

Reference

Preparation of dihydroimidazo[2,1-b]thiazoles and dihydro-5H-thiazolo[3,2-a]pyrimidines with 5-HT receptor affinity

, World Intellectual Property Organization, , ,

Production Method 13

204452-94-8

95333-17-8

17450-68-9

Reaction Conditions

1.1 Solvents: Toluene ;  overnight, reflux
1.2 Solvents: Dimethylformamide ;  overnight, reflux
1.3 Reagents: Ammonium hydroxide Solvents: Water ;  cooled

Reference

Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

Wang, Youxin; Chen, Feifei; Di, Hongxia; Xu, Yong; Xiao, Qiang; et al, Journal of Medicinal Chemistry, 2016, 59(7), 3215-3230

Benzofuran-4-carbonitrile Raw materials

• 4-bromo-1-benzofuran
• 2-(3-bromophenoxy)acetaldehyde diethyl acetal
• 1-bromo-3-(2,2-diethoxyethyl)benzene
• 4-Benzofurancarbonitrile, 6,7-dihydro-
• 6-bromo-1-benzofuran

Benzofuran-4-carbonitrile Preparation Products

• BENZOFURAN-6-CARBONITRILE (17450-68-9)
• Benzofuran-4-carbonitrile (95333-17-8)

• 1. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 4. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 5. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofurans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

• 29021-90-7(Dibenzo[b,d]furan-3-carbonitrile)
• 33763-36-9(Dibenzo[b,d]furan-3,7-dicarbonitrile)
• 84540-55-6(Benzo[b]naphtho[2,3-d]furan,methyl- (6CI,9CI))
• 55877-31-1(1-Benzofuran-3-carbonitrile)
• 79002-39-4(1-Benzofuran-5-carbonitrile)
• 7396-53-4(Dibenzofuran, 1,8-dimethyl-)
• 60826-62-2(Dibenzofuran, methyl-)
• 7320-50-5(Dibenzofuran, 1-methyl-)
• 150612-64-9(5-Benzofurancarbonitrile,3-methyl-)
• 17450-68-9(BENZOFURAN-6-CARBONITRILE)