Cas no 78-96-6 (1-Aminopropan-2-ol)

1-Aminopropan-2-ol is a polar amine capable of forming hydrogen bonds, exhibiting high solubility in water and various organic solvents. Its chemical stability allows it to be used as a building block for various applications, including pharmaceuticals, agrochemicals, and specialty chemicals, where its unique reactivity can enable efficient synthesis routes.
1-Aminopropan-2-ol structure
1-Aminopropan-2-ol structure
Product Name:1-Aminopropan-2-ol
CAS No:78-96-6
MF:C3H9NO
MW:75.1096608638763
MDL:MFCD00008139
CID:34146
PubChem ID:4
Update Time:2025-10-31

1-Aminopropan-2-ol Chemical and Physical Properties

Names and Identifiers

    • DL-1-Amino-2-propanol
    • DL-Isopropanolamine
    • (+/-)-Isopropanolamine
    • (+/-)-1-Amino-2-propanol
    • (±)-1-Amino-2-propanol
    • 1-Amino-2-propanol
    • 2-Propanol,1-amino-
    • Amino-2-propanol
    • Isopropanolamine
    • 2-Hydroxypropylamine
    • (鹵)-1-Amino-2-propanol
    • (鹵)-Isopropanolamine
    • (RS)-1-Amino-2-hydroxypropane
    • (RS)-1-amino-2-propanol
    • 1-Amino-2-hydroxypropane
    • 1-Aminopropan-2-ol
    • 2-Hydroxy-1-propylamine
    • 2-Hydroxypropanamine
    • 2-Propanol, 1-amino-
    • 2-Propanol, 1-amino-, (鹵)-
    • propan-2-ol, 1-amino-
    • (鹵)1-amino-2-propanol
    • (脗鹵)-1-Amino-2-propanol
    • 1-Amino-2-Hydroxypropanamine
    • 1-Aminoisopropylalcohol
    • 1-METHYL-2-AMINOETHANOL
    • 2-Amino-1-methylethanol
    • 2-Hydroxy-1-methylethanol
    • 2-Hydroxy-1-propanamine
    • Aminopropanol
    • hmdb
    • METHYLETHANOLAMINE
    • MIPA
    • monoisopropanolamine
    • mono-isopropanolamine
    • Mono-iso-propanolamine
    • NMEA
    • WLN: Z1YQ1
    • 偽-Aminoisopropyl alcohol
    • 尾-AMINOISOPROPANOL
    • (±)-Isopropanolamine
    • 2-Propanol, 1-amino-, (±)-
    • (±)1-amino-2-propanol
    • (?±)-1-Amino-2-propanol
    • α-Aminoisopropyl alcohol
    • β-AMINOISOPROPANOL
    • Threamine
    • alpha-Aminoisopropyl alcohol
    • 1-amino-propan-2-ol
    • .alpha.-Aminoisopropyl alcohol
    • (RS)-1-amin
    • 1-Amino-2-propanol (ACI)
    • (2-Hydroxy-2-methylethyl)amine
    • 1-Aminoisopropanol
    • Additive CA
    • NSC 3188
    • DL-Isopropanolamine,97%
    • UNII-UE40BY1BZW
    • EN300-20160
    • 1-AMINO-2-PROPANOL [FHFI]
    • NSC-3188
    • (+/-)-1-Amino-2-propanol, analytical standard
    • CS-W016685
    • FEMA NO. 3965
    • (.+/-.)-1-Amino-2-propanol
    • (2RS) 1-amino-2-propanol
    • EINECS 201-162-7
    • Aminopropan-2-ol
    • D-1-aminopropan-2-ol
    • beta-Aminoisopropanol
    • (rac)-1-amino-2-propanol
    • 1-amino-2 propanol
    • DTXCID901764
    • G75932
    • UE40BY1BZW
    • Tox21_301704
    • 1-amino-2(R,S)-propanol
    • 3-amino-2-propanol
    • F2190-0369
    • 2-hydroxy-2-methyl-ethylamine
    • BBL027685
    • 1-Aminopropanol-(2)
    • BRN 0605275
    • (?)-1-Amino-2-propanol, 94%, remainder 2-amino-1-propanol
    • MFCD00008139
    • C05771
    • Amino-2-propanol, 93%
    • A1229
    • NS00007157
    • 2-Propanol, 1-amino-, (R)-
    • 78-96-6
    • propane, 1-amino-2-hydroxy-
    • Z104477092
    • DL-1-Amino-2-propanol, >=90%
    • NSC3188
    • NCGC00257540-01
    • (S)-(+)-Isopropanolamine
    • 2-Propanol, 1-amino- (8CI,9CI)
    • 1-AMINO-2-PROPANOL, (+/-)-
    • CHEBI:19030
    • 2-hydroxypropyl-amine
    • BCP08083
    • 1674-56-2
    • EC 201-162-7
    • AKOS000120495
    • SB44696
    • 2-Propanol, 1-amino-, (.+/-.)-
    • bmse000305
    • CCRIS 2284
    • 4-04-00-01665 (Beilstein Handbook Reference)
    • AKOS016042334
    • A0406
    • DB-013106
    • 3-aminopropan-2-ol
    • CAS-78-96-6
    • A5358
    • 1-Amin-iso-proylalcohol
    • SB83757
    • HY-W015969
    • Q161580
    • racemic 1-amino-2-propanol
    • 2-hydroxy-1-aminopropane
    • J-660020
    • 2-hydroxy-propylamine
    • 1-amino-propane-2-ol
    • rac-1-amino-2-propanol
    • D-1-amino-2-propanol
    • SB44651
    • (2rs)-1-amino-2-propanol
    • SY002691
    • HSDB 5224
    • CHEMBL326602
    • STL308732
    • 2-Propanol, 1-amino-, (S)-
    • DTXSID9021764
    • 1-AMINO-2-PROPANOL [HSDB]
    • AI3-14653
    • MDL: MFCD00008139
    • Inchi: 1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3
    • InChI Key: HXKKHQJGJAFBHI-UHFFFAOYSA-N
    • SMILES: OC(CN)C
    • BRN: 605275

Computed Properties

  • Exact Mass: 75.06840
  • Monoisotopic Mass: 75.068413911g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 5
  • Rotatable Bond Count: 1
  • Complexity: 22.9
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -1
  • Topological Polar Surface Area: 46.2
  • Surface Charge: 0

Experimental Properties

  • Color/Form: Colorless or yellowish liquid. It smells slightly of ammonia.
  • Density: 0.973 g/mL at 25 °C (lit.)
  • Melting Point: -2 °C (lit.)
  • Boiling Point: 160 °C (lit.)
  • Flash Point: 165 °F
  • Refractive Index: n20/D 1.4478(lit.)
  • PH: 11.3 (10g/l, H2O, 20℃)
  • Water Partition Coefficient: Soluble
  • Stability/Shelf Life: Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic.
  • PSA: 46.25000
  • LogP: 0.02620
  • FEMA: 3965 | 1-AMINO-2-PROPANOL
  • Sensitiveness: Hygroscopic
  • Freezing Point: 1.4℃
  • Vapor Pressure: <1 mm Hg ( 20 °C)
  • pka: 12.92±0.35(Predicted)
  • Solubility: It is miscible with water and ethanol, but insoluble in ether.

1-Aminopropan-2-ol Security Information

  • Symbol: GHS05
  • Prompt:dangerous
  • Signal Word:Danger
  • Hazard Statement: H314
  • Warning Statement: P280,P305+P351+P338,P310
  • Hazardous Material transportation number:UN 2735 8/PG 2
  • WGK Germany:1
  • Hazard Category Code: 21/22-34
  • Safety Instruction: 23-26-36-45-36/37
  • RTECS:UA5775000
  • Hazardous Material Identification: C Xn
  • Hazard Level:8
  • Packing Group:II
  • TSCA:Yes
  • Storage Condition:2-8°C
  • Toxicity:LD50 orl-rat: 1715 mg/kg GTPZAB 30(7),46,86
  • Explosive Limit:1.9-10.4%(V)
  • Risk Phrases:R34
  • Safety Term:S23;S26;S36;S45
  • HazardClass:8
  • PackingGroup:II

1-Aminopropan-2-ol Customs Data

  • HS CODE:29221980
  • Customs Data:

    China Customs Code:

    2922199090

    Overview:

    2922199090. Other amino alcohols and their ethers,Esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

1-Aminopropan-2-ol Pricemore >>

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1-Aminopropan-2-ol Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Phenol Catalysts: Iron (reaction products, palladium-iron complex with wool) ,  Palladium (reaction products, palladium-iron complex with wool) Solvents: Butyl ether ,  Water ;  24 h, 95 °C
Reference
Hydration of alkenes catalyzed by wool-palladium-iron complex
Jia, Bin; Yang, Xiu; Huang, Mei-Yu; Jiang, Ying-Yan, Reactive & Functional Polymers, 2003, 57(2-3), 163-168

Production Method 2

Reaction Conditions
1.1 Reagents: Barium hydroxide Catalysts: Water
Reference
Simple preparations of some hydantoins of phenylalanine and α-methylphenylalanine and their chiral stability during N3-alkylation. A route to the synthesis of chiral amines
Anteunis, M. J. O.; Spiessens, L.; De Witte, M.; Callens, R.; Reyniers, F., Bulletin des Societes Chimiques Belges, 1987, 96(6), 459-65

Production Method 3

Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: Methanol ,  Water
1.2 Solvents: Methanol ,  Water
1.3 Reagents: Hydrochloric acid
Reference
Kilogram scale synthesis of the pyrazinone acetic acid core of an orally efficacious thrombin inhibitor
Fleitz, Fred J.; Lyle, Terry A.; Zheng, Nan; Armstrong, Joseph D. III; Volante, R. P., Synthetic Communications, 2000, 30(17), 3171-3180

Production Method 4

Reaction Conditions
Reference
Synthetic nitrogenous fibers. III. Synthesis of aminoisopropyl alcohol, formation of the salts with some dicarboxylic acids, and the polymers therefrom
Sasaki, Shuiku; Ri, Shunnei, Nippon Nogei Kagaku Kaishi, 1943, 19, 805-8

Production Method 5

Reaction Conditions
1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Water ;  3 h, 60 °C
Reference
Efficient Preparation of Biologically Important 1,2-Amino Alcohols
Gupta, Pankaj; Rouf, Abdul; Shah, Bhahwal A.; Mukherjee, Debaraj; Taneja, Subhash C., Synthetic Communications, 2013, 43(4), 505-519

Production Method 6

Reaction Conditions
1.1 Solvents: Tetrahydrofuran ;  12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt
Reference
Expanding monomer scope and enabling post-modification in photocontrolled radical ring-opening polymerization of vinylcyclopropanes by an iodine transfer strategy
Zhang, Dong-Yang; Han, Dong; Li, Yue; Chen, Dian-Feng, Polymer Chemistry, 2022, 13(40), 5691-5699

Production Method 7

Reaction Conditions
1.1 Reagents: Ethylenediamine Solvents: Tetrahydrofuran
Reference
Convenient methods for the hydrolysis of oxazolidinones to vicinal aminoalcohols
Katz, Steven J.; Bergmeier, Stephen C., Tetrahedron Letters, 2002, 43(4), 557-559

Production Method 8

Reaction Conditions
1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Nickel Solvents: Methanol
Reference
Hydrogenation of α-oximino ketones in an ammoniacal medium
Samne, Suzanne; Freon, Pierre, Compt. rend., 1959, 249, 2340-1

Production Method 9

Reaction Conditions
1.1 Reagents: Ammonia Solvents: Methanol ,  Water ;  rt; overnight, 15 - 20 °C
Reference
Resolution of β-aminoalcohols and 1,2-diamines using fractional crystallization of diastereomeric salts of dehydroabietic acid
Zhang, Guangyou; Liao, Yuquing; Wang, Zhaohui; Nohira, Hiroyuki; Hirose, Takuji, Tetrahedron: Asymmetry, 2003, 14(21), 3297-3300

Production Method 10

Reaction Conditions
1.1 Reagents: Ammonium hydroxide
Reference
Aminophenyl-2-oxazolines as local antiseptics
Leffler, M. T.; Adams, Roger, Journal of the American Chemical Society, 1937, 59, 2252-8

Production Method 11

Reaction Conditions
1.1 Reagents: Ammonia Solvents: Methanol ,  Water ;  12 h, rt
Reference
Polyether/Polythioether Synthesis via Ring-Opening Polymerization of Epoxides and Episulfides Catalyzed by Alkali Metal Carboxylates
Gao, Tianle; Xia, Xiaochao ; Tajima, Kenji ; Yamamoto, Takuya ; Isono, Takuya ; et al, Macromolecules (Washington, 2022, 55(21), 9373-9383

Production Method 12

Reaction Conditions
1.1 Reagents: Ammonium formate ,  Zinc Solvents: Methanol
Reference
Lewis acid mediated intramolecular C-O bond formation of alkanol-epoxide leading to substituted morpholine and 1,4-oxazepane derivatives: total synthesis of (±)-Viloxazine
Ghosh, Priya; Deka, Manash J.; Saikia, Anil K., Tetrahedron, 2016, 72(5), 690-698

1-Aminopropan-2-ol Raw materials

1-Aminopropan-2-ol Preparation Products

1-Aminopropan-2-ol Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:78-96-6)Amino-2-propanol
Order Number:sfd5588
Stock Status:in Stock
Quantity:200kg
Purity:99%
Pricing Information Last Updated:Friday, 19 July 2024 14:34
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:78-96-6)DL-1-Amino-2-propanol, ≥ 92.0%
Order Number:LE17301;LE8064198;LE3870
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:15
Price ($):discuss personally

1-Aminopropan-2-ol Spectrogram

13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR

Additional information on 1-Aminopropan-2-ol

Professional Introduction to 1-Aminopropan-2-ol (CAS No. 78-96-6)

1-Aminopropan-2-ol, also known by its CAS number 78-96-6, is a versatile organic compound that has garnered significant attention in the field of chemical and pharmaceutical research. This compound, commonly referred to as isopropylamine, is a secondary amine with a molecular structure that makes it highly reactive and useful in various synthetic applications.

The chemical formula of 1-Aminopropan-2-ol is C?H?NO, reflecting its three-carbon chain with an amine functional group attached to the second carbon. This configuration imparts unique properties to the molecule, making it a valuable intermediate in the synthesis of more complex organic compounds. The compound is typically found as a colorless liquid with a characteristic pungent odor, which is a hallmark of secondary amines.

In recent years, 1-Aminopropan-2-ol has been extensively studied for its potential applications in pharmaceuticals, agrochemicals, and specialty chemicals. One of the most notable areas of research has been its role as a precursor in the synthesis of active pharmaceutical ingredients (APIs). The compound's ability to undergo various chemical reactions, such as nucleophilic substitution and condensation reactions, makes it an indispensable building block in drug development.

A particularly intriguing aspect of 1-Aminopropan-2-ol is its involvement in the synthesis of biologically active molecules. Researchers have leveraged its reactivity to develop novel compounds with potential therapeutic applications. For instance, studies have shown that derivatives of 1-Aminopropan-2-ol can serve as intermediates in the production of antiviral and antibacterial agents. These findings highlight the compound's significance in addressing emerging health challenges.

The pharmaceutical industry has also explored the use of 1-Aminopropan-2-ol in the development of vaccines and biologics. Its structural flexibility allows for the creation of complex molecules that can mimic natural biological pathways, thereby enhancing drug efficacy and target specificity. Additionally, the compound's compatibility with various solvents and reaction conditions makes it a preferred choice for industrial-scale synthesis.

Beyond pharmaceuticals, 1-Aminopropan-2-ol finds applications in agrochemicals, where it is used to synthesize herbicides and pesticides. These compounds are essential for modern agriculture, helping to protect crops from pests and diseases while maintaining high yields. The role of 1-Aminopropan-2-ol in this context underscores its importance in supporting global food security.

In specialty chemicals, 1-Aminopropan-2-ol is utilized in the production of polymers, coatings, and adhesives. Its ability to act as a monomer or cross-linking agent contributes to the development of advanced materials with tailored properties. These materials are used across various industries, from automotive to construction, demonstrating the broad utility of this compound.

The environmental impact of using 1-Aminopropan-2-ol has also been a focus of research. Studies have investigated its biodegradability and potential effects on aquatic ecosystems. Efforts have been made to develop more sustainable synthetic routes that minimize waste and reduce environmental footprint. These initiatives align with global trends toward greener chemistry practices.

The future prospects for 1-Aminopropan-2-ol appear promising, with ongoing research uncovering new applications and refining existing processes. Advances in catalysis and process optimization are expected to enhance the efficiency and scalability of its production. As scientific understanding continues to evolve, so too will the ways in which this versatile compound is utilized.

In conclusion, 1-Aminopropan-2-ol (CAS No. 78-96-6) is a multifaceted organic compound with significant roles across multiple industries. Its reactivity and structural properties make it indispensable in pharmaceuticals, agrochemicals, and specialty chemicals. As research progresses, new applications and sustainable practices will further solidify its importance in modern chemistry.

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Suzhou Senfeida Chemical Co., Ltd
(CAS:78-96-6)Amino-2-propanol
sfd5588
Purity:99%
Quantity:200kg
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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:78-96-6)DL-1-Amino-2-propanol, ≥ 92.0%
LE17301;LE8064198;LE3870
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
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