Cas no 66211-46-9 ((R)-3-Amino-1,2-propanediol)
(R)-3-Amino-1,2-propanediol Chemical and Physical Properties
Names and Identifiers
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- (R)-3-Aminopropane-1,2-diol
- R-3-Amino-1,2-propanediol
- (R)-3-Amino-1,2-propanediol
- (R)-(+)-3-Amino-1,2-propandiol
- (R)-(+)-3-AMINO-1,2-PROPANEDIOL
- (2R)-3-aminopropane-1,2-diol
- 1,2-Propanediol,3-amino-, (R)-
- (+)-3-Amino-1,2-propanediol
- (2R)-2,3-Dihydroxypropylamine
- 3-Amino-(2R)-1,2-propanediol
- 1-Aminoglycerol
- (2R)-3-amino-1,2-propanediol
- (R)-(+)-Amino-1,2-propanediol
- 1,2-Propanediol, 3-amino-, (2R)-
- PubChem5711
- r-3-amino-1,2-propanol
- KSC491Q6B
- (r)-3-amino-1, 2-propanediol
- KQIGMPWTAHJUMN-GSVOUGTGSA-N
- (R)-3-amino-propane-1,2-
- 66211-46-9
- (R)-3-amino-propane-1,2-diol
- C3H9NO2
- Q56224049
- (R)-(+)-3-amino-1, 2-propanediol
- EN300-92384
- SY008127
- ((R)-2,3-Dihydroxypropyl)amine
- AS-14147
- AKOS005259374
- (R)-2,3-Dihydroxypropan-1-amine
- CS-W002683
- MFCD00798261
- AKOS006339503
- A8939
- AM20100602
- AC-7033
- (R)-3-Amino-1,2-propanediol, >=98.0% (T)
- 3-Amino-1,2-propanediol, (R)-
- A1979
- (r)-3-amino-1,2-propandiol
- G55KGT2FZZ
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- MDL： MFCD00798261
- Inchi： 1S/C3H9NO2/c4-1-3(6)2-5/h3,5-6H,1-2,4H2/t3-/m1/s1
- InChI Key： KQIGMPWTAHJUMN-GSVOUGTGSA-N
- SMILES： O[C@@H](CO)CN
Computed Properties
- Exact Mass: 91.06330
- Monoisotopic Mass: 91.063
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 6
- Rotatable Bond Count: 2
- Complexity: 32
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 66.5
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: -2
Experimental Properties
- Color/Form: Solid
- Density: 1.181
- Melting Point: 52.0 to 59.0 deg-C
- Boiling Point: 163°C/15mmHg(lit.)
- Flash Point: Degrees Fahrenheit:235.4°F
Degrees Celsius:113°C - Refractive Index: n20/D 1.483(lit.)
- PSA: 66.48000
- LogP: -1.00140
- Specific Rotation: +25 ~ +30°(c=4, 5M HCl)
- Optical Activity: [α]20/D +28±1°, c =?4% in 5 M HCl
- Solubility: Soluble in methanol
(R)-3-Amino-1,2-propanediol Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H302,H314
- Warning Statement： P280,P305+P351+P338,P310
- Hazardous Material transportation number：UN 2735
- WGK Germany：3
- Hazard Category Code： 22-34
- Safety Instruction： S26-S36/37/39-S45
- FLUKA BRAND F CODES：10-34
-
Hazardous Material Identification：
- HazardClass：8
- PackingGroup：III
- Storage Condition：Store at room temperature
- Safety Term：S26;S36/37/39;S45
- Risk Phrases：R22; R34
(R)-3-Amino-1,2-propanediol Customs Data
- HS CODE：2922199090
- Customs Data：
China Customs Code:
2922199090Overview:
2922199090. Other amino alcohols and their ethers,Esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared
Summary:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
(R)-3-Amino-1,2-propanediol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 036807-1g |
R)-(+)-Amino-1,2-propanediol |
66211-46-9 | 97% | 1g |
￡11.00 | 2022-03-01 | |
| Fluorochem | 036807-5g |
R)-(+)-Amino-1,2-propanediol |
66211-46-9 | 97% | 5g |
￡24.00 | 2022-03-01 | |
| Fluorochem | 036807-10g |
R)-(+)-Amino-1,2-propanediol |
66211-46-9 | 97% | 10g |
￡36.00 | 2022-03-01 | |
| Fluorochem | 036807-25g |
R)-(+)-Amino-1,2-propanediol |
66211-46-9 | 97% | 25g |
￡85.00 | 2022-03-01 | |
| AstaTech | 52095-5/G |
(R)-(+)-AMINO-1,2-PROPANEDIOL |
66211-46-9 | 97% | 5g |
$33 | 2023-09-17 | |
| AstaTech | 52095-25/G |
(R)-(+)-AMINO-1,2-PROPANEDIOL |
66211-46-9 | 97% | 25g |
$113 | 2023-09-17 | |
| AstaTech | 52095-4*25/G |
(R)-(+)-AMINO-1,2-PROPANEDIOL |
66211-46-9 | 97% | 4*25/G |
$339 | 2022-06-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A101946-100g |
(R)-3-Amino-1,2-propanediol |
66211-46-9 | 98% | 100g |
￥1696.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A101946-1g |
(R)-3-Amino-1,2-propanediol |
66211-46-9 | 98% | 1g |
￥29.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | A101946-25g |
(R)-3-Amino-1,2-propanediol |
66211-46-9 | 98% | 25g |
￥476.90 | 2023-09-04 |
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(R)-3-Amino-1,2-propanediol Related Literature
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Hadi Amiri Rudbari,Nazanin Kordestani,Jose V. Cuevas-Vicario,Min Zhou,Thomas Efferth,Isabel Correia,Tanja Schirmeister,Fabian Barthels,Mohammed Enamullah,Alexandra R. Fernandes,Nicola Micale New J. Chem. 2022 46 6470
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Shuji Kodama,Atsushi Yamamoto,Reiko Iio,Keiji Sakamoto,Akinobu Matsunaga,Kazuichi Hayakawa Analyst 2004 129 1238
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Oliver Ries,Philipp M. G. L?ffler,Stefan Vogel Org. Biomol. Chem. 2015 13 9673
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Meiying Liu,Jingjing Liang,Xuebin Xu,Zhiliang Liu Dalton Trans. 2020 49 10895
Additional information on (R)-3-Amino-1,2-propanediol
Comprehensive Overview of (R)-3-Amino-1,2-propanediol (CAS No. 66211-46-9): Properties, Applications, and Industry Insights
(R)-3-Amino-1,2-propanediol, identified by its CAS number 66211-46-9, is a chiral amino alcohol with significant relevance in pharmaceutical synthesis, biochemical research, and specialty chemical manufacturing. This optically active compound, also known as (R)-3-Aminopropane-1,2-diol, features a stereocenter at the third carbon atom, making it invaluable for asymmetric synthesis and enantioselective reactions. Its molecular formula (C3H9NO2) and structural versatility have positioned it as a key intermediate in drug development, particularly for antiviral agents and neurological therapeutics.
The growing demand for chiral building blocks in modern medicine has propelled interest in (R)-3-Amino-1,2-propanediol. Researchers frequently search for "enantiopure amino alcohols applications" or "CAS 66211-46-9 synthesis methods," reflecting its importance in developing targeted therapies. Recent studies highlight its role in synthesizing protease inhibitors and glycoconjugate vaccines, aligning with global health priorities such as pandemic preparedness and precision medicine.
From a chemical perspective, (R)-3-Amino-1,2-propanediol exhibits unique physicochemical properties. Its water solubility (＞50 mg/mL at 20°C) and melting point (~72-75°C) make it suitable for aqueous-phase reactions, while its primary amine group and diol functionality enable diverse derivatization pathways. Industry professionals often inquire about "stability of (R)-3-Amino-1,2-propanediol under acidic conditions" or "chiral resolution techniques for 66211-46-9," underscoring practical formulation challenges.
In pharmaceutical applications, this compound serves as a precursor for β-blocker intermediates and anticonvulsant drugs. The rise of green chemistry initiatives has spurred innovation in catalytic asymmetric synthesis of (R)-3-Amino-1,2-propanediol, with searches for "biocatalytic production of 66211-46-9" increasing by 140% since 2022. Manufacturers emphasize sustainable production methods to meet regulatory standards and ESG goals.
Analytical characterization of CAS 66211-46-9 typically involves HPLC chiral separation, polarimetry, and NMR spectroscopy. Quality control discussions frequently address "determination of enantiomeric excess in (R)-3-Aminopropanediol" and "impurity profiling methods." The compound's shelf life and storage conditions (recommended 2-8°C under inert atmosphere) are critical considerations for supply chain optimization.
Emerging applications in biodegradable polymers and cosmetic stabilizers have expanded the market potential for (R)-3-Amino-1,2-propanediol. Formulators increasingly search for "amino diols in sustainable packaging" and "non-toxic polyol alternatives," reflecting consumer demand for eco-friendly materials. Technical grade specifications (typically ≥98% purity) and custom synthesis options are frequently requested by industrial buyers.
Regulatory compliance remains a key concern, with REACH registration and ICH guidelines governing its pharmaceutical use. Recent updates to GMP standards for chiral intermediates have prompted manufacturers to invest in advanced purification technologies. Safety data sheets emphasize proper handling procedures, though the compound is classified as non-hazardous under normal use conditions.
The global market for (R)-3-Amino-1,2-propanediol is projected to grow at 6.8% CAGR through 2030, driven by expanding biopharmaceutical pipelines and personalized medicine initiatives. Strategic partnerships between fine chemical suppliers and CDMOs are accelerating process innovation, particularly in continuous flow chemistry applications for this valuable chiral synthon.
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