• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
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• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Chemical Profile of (S)-3-Amino-1,2-propanediol (CAS No. 61278-21-5)

(S)-3-Amino-1,2-propanediol, with the chemical formula C?H?NO?, is a significant chiral compound widely utilized in pharmaceutical synthesis and biochemical research. Its CAS number, 61278-21-5, uniquely identifies it in the chemical registry, underscoring its importance in industrial and academic applications. This compound is an enantiomer of its racemic counterpart, exhibiting distinct stereochemical properties that make it invaluable in the development of enantioselective drugs and catalysts.

The structural configuration of (S)-3-Amino-1,2-propanediol imparts unique reactivity and solubility characteristics, making it a preferred building block in organic synthesis. Its two hydroxyl groups and an amine group allow for diverse functionalization pathways, enabling the creation of complex molecules essential for therapeutic applications. Recent advancements in asymmetric synthesis have highlighted its role in constructing enantiomerically pure intermediates for APIs (Active Pharmaceutical Ingredients), where chirality is critical for drug efficacy and safety.

In the realm of pharmaceutical research, (S)-3-Amino-1,2-propanediol has garnered attention for its potential in developing novel therapeutic agents. For instance, studies have demonstrated its utility in synthesizing chiral auxiliaries and ligands that enhance the selectivity of transition metal-catalyzed reactions. These advancements are particularly relevant in the context of green chemistry initiatives, where minimizing racemization and improving atom economy are paramount.

The compound's significance extends to biochemical applications, where it serves as a precursor in the synthesis of amino acids and nucleoside analogs. Researchers have leveraged its structural features to develop innovative enzymatic cascades that facilitate the production of high-value biochemicals. Notably, recent publications highlight its role in constructing peptidomimetics, which are increasingly being explored for their potential as antiviral and anticancer agents.

Industrial-scale production of (S)-3-Amino-1,2-propanediol has also seen significant progress, with biocatalytic methods gaining traction over traditional chemical synthesis. Enzymes such as ketoreductases and transaminases have been engineered to efficiently produce this compound with high enantioselectivity. This shift toward biocatalysis aligns with global trends toward sustainable manufacturing practices, reducing environmental impact while maintaining high product purity.

The compound's versatility is further underscored by its applications in material science. For example, it has been employed in the development of chiral polymers that exhibit unique optical properties, finding use in sensors and liquid crystals. These materials are particularly valuable in nanotechnology applications, where precise control over molecular architecture is essential for functional performance.

Future research directions for (S)-3-Amino-1,2-propanediol are likely to focus on expanding its utility in drug discovery and catalysis. Innovations such as flow chemistry and photoredox catalysis may unlock new synthetic pathways, further enhancing its accessibility and applicability. Collaborative efforts between academia and industry are expected to drive these developments, ensuring that this compound remains at the forefront of chemical innovation.

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• 71232-13-8(2,3-Butanediol, 1,4-diamino-, (2R,3S)-rel-)
• 66211-46-9((R)-3-Amino-1,2-propanediol)
• 2799-17-9((2S)-1-aminopropan-2-ol)
• 616-29-5(1,3-Diamino-2-hydroxypropane)
• 209849-99-0((2S)-3-Aminopropane-1,2-diol hydrochloride)
• 616-30-8(3-Amino-1,2-propandiol)