Production Method 1

108-87-2

7443-52-9

96184-81-5

5454-79-5

7731-28-4

69814-26-2

7443-55-2

7443-70-1

2043-61-0

100-49-2

590-67-0

7731-29-5

1193-63-1

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ,  Oxygen Catalysts: Nitric acid ,  Sodium, [μ13-[1,15-bis[[di(hydroxy-κO:κO)phenylsilyl]oxy-κO]-1,3,5,7,9,11,13,15-… Solvents: Acetonitrile

Reference

A heterometallic (Fe6Na8) cage-like silsesquioxane: synthesis, structure, spin glass behavior and high catalytic activity

Bilyachenko, Alexey N.; Levitsky, Mikhail M.; Yalymov, Alexey I.; Korlyukov, Alexander A.; Vologzhanina, Anna V.; et al, RSC Advances, 2016, 6(53), 48165-48180

trans-2-Methylcyclohexanol Raw materials

• Methylcyclohexane

trans-2-Methylcyclohexanol Preparation Products

• 4-Oxocyclohexanecarbaldehyde (96184-81-5)
• cis-3-methylcyclohexan-1-ol (5454-79-5)
• cis-4-Methylcyclohexanol (7731-28-4)
• 3-oxocyclohexane-1-carbaldehyde (69814-26-2)
• trans-3-methylcyclohexan-1-ol (7443-55-2)
• cis-2-Methylcyclohexanol (7443-70-1)
• trans-2-Methylcyclohexanol (7443-52-9)
• cyclohexanecarbaldehyde (2043-61-0)
• Cyclohexanemethanol (100-49-2)
• 1-Methylcyclohexanol (590-67-0)
• trans-4-Methylcyclohexanol (7731-29-5)
• 2-oxocyclohexanecarbaldehyde (1193-63-1)

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• 5. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526

• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of trans-2-Methylcyclohexanol (CAS No. 7443-52-9): Properties, Applications, and Industry Insights

trans-2-Methylcyclohexanol (CAS No. 7443-52-9) is a cyclic alcohol widely recognized for its versatile applications in fragrances, organic synthesis, and specialty chemicals. As a stereoisomer of 2-methylcyclohexanol, this compound exhibits distinct physicochemical properties that make it valuable in both industrial and research settings. The growing demand for flavor and fragrance ingredients and green chemistry alternatives has heightened interest in this molecule, particularly in sustainable manufacturing processes.

The molecular structure of trans-2-Methylcyclohexanol features a hydroxyl group (-OH) attached to a six-membered ring with a methyl substituent in the trans configuration. This spatial arrangement influences its boiling point (≈165°C), solubility (moderate in water, high in organic solvents), and odor profile (minty, woody notes). Researchers frequently explore its role as a chiral building block in asymmetric synthesis, aligning with the trend toward stereoselective catalysis—a hot topic in pharmaceutical and agrochemical R&D.

In the fragrance industry, trans-2-Methylcyclohexanol serves as a key intermediate for synthetic musk compounds and essential oil analogs. Its stability under acidic conditions makes it preferable for formulating long-lasting perfumes and household cleaners. Recent studies highlight its potential in bio-based solvents, addressing the global push for eco-friendly chemical solutions. A 2023 market analysis revealed a 12% annual growth in demand for such intermediates, driven by consumer preference for sustainable personal care products.

From a synthetic perspective, this compound is often produced via catalytic hydrogenation of 2-methylcyclohexanone or isomerization of its cis counterpart. Innovations in heterogeneous catalysis (e.g., using ruthenium nanoparticles) have improved yield and selectivity—topics frequently searched in academic databases like SciFinder. Environmental considerations also spur interest in enzymatic conversion methods, with patents filed for biocatalytic production using engineered yeast strains.

Safety and handling of trans-2-Methylcyclohexanol (CAS 7443-52-9) follow standard laboratory protocols. While not classified as hazardous under major regulatory frameworks, proper ventilation and PPE are recommended during handling. Its biodegradability (>80% in 28 days per OECD 301F tests) positions it favorably against petrochemical-derived alcohols, resonating with ESG (Environmental, Social, and Governance) metrics increasingly prioritized by investors.

Emerging applications include its use in liquid crystal formulations for electronic displays and as a modifier in polymer coatings. The compound’s compatibility with UV-curable resins has attracted attention in 3D printing material development—a sector projected to grow at 24% CAGR through 2030. Analytical techniques like GC-MS and chiral HPLC remain critical for quality control, as purity thresholds exceed 98% for pharmaceutical-grade batches.

For researchers querying "trans-2-Methylcyclohexanol solubility data" or "CAS 7443-52-9 synthetic routes," recent publications emphasize solvent-free reaction systems and continuous flow chemistry. The compound’s NMR spectra (characteristic peaks at δ 1.2–1.8 ppm for cyclohexyl protons) are well-documented in spectral libraries, facilitating rapid identification. Regulatory databases show compliance with REACH and TSCA, though regional variations in chemical inventory listings warrant verification before international shipments.

Future directions may explore trans-2-Methylcyclohexanol derivatives for drug delivery systems, leveraging its lipid solubility. Computational chemistry studies (e.g., DFT calculations) predict enhanced binding affinity when incorporated into macrocyclic structures—an area gaining traction in medicinal chemistry forums. As industries seek drop-in replacements for restricted substances, this compound’s structural flexibility ensures continued relevance in green chemistry initiatives worldwide.

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