Production Method 1

38580-68-6

96184-81-5

Reaction Conditions

1.1 Reagents: Oxalyl chloride Solvents: Dimethyl sulfoxide ,  Dichloromethane ;  -78 °C; 10 min, -78 °C; 30 min, -78 °C
1.2 Solvents: Dichloromethane ;  20 min, -78 °C; 30 min, -78 °C
1.3 Reagents: Trimethylamine ;  -78 °C → rt

Reference

Stereoselective total synthesis of (±)-vindeburnol and (±)-16-epi-vindeburnol

Chen, Xiangtao; Yu, Lei; Wang, Huijing; Zhang, Wen; Tang, Pei; et al, Chemical Communications (Cambridge, 2021, 57(88), 11669-11672

Production Method 2

96184-81-5

Reaction Conditions

Reference

Preparation of heterocyclic compounds containing basic group as CXCR4 antagonists

, World Intellectual Property Organization, , ,

Production Method 3

108-87-2

96184-81-5

5454-79-5

7731-28-4

69814-26-2

7443-55-2

7443-70-1

7443-52-9

2043-61-0

100-49-2

590-67-0

7731-29-5

1193-63-1

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ,  Oxygen Catalysts: Nitric acid ,  Sodium, [μ13-[1,15-bis[[di(hydroxy-κO:κO)phenylsilyl]oxy-κO]-1,3,5,7,9,11,13,15-… Solvents: Acetonitrile

Reference

A heterometallic (Fe6Na8) cage-like silsesquioxane: synthesis, structure, spin glass behavior and high catalytic activity

Bilyachenko, Alexey N.; Levitsky, Mikhail M.; Yalymov, Alexey I.; Korlyukov, Alexander A.; Vologzhanina, Anna V.; et al, RSC Advances, 2016, 6(53), 48165-48180

Production Method 4

96184-80-4

96184-81-5

Reaction Conditions

1.1 Solvents: Water ;  reflux
1.2 Catalysts: 1H-Imidazolium, 1-methyl-3-(4-sulfobutyl)-, tetrafluoroborate(1-) (1:1) ;  10 h, reflux

Reference

Method for preparing cyclohexyl formaldehyde by ionic liquid catalysis

, China, , ,

Production Method 5

94458-92-1

96184-81-5

Reaction Conditions

1.1 Reagents: Methanol Solvents: Methanol

Reference

Chemistry of enol ethers. LXXXVI. Diels-Alder reaction of 2-(trimethylsiloxy)-1,3-dienes with α,β-unsaturated aldehydes. 1-Formyl-4-(trimethylsiloxy)-3-cyclohexenes and 1-formyl-4-oxocyclohexanes

Makin, S. M.; Shavrygina, O. A.; Nguyen Phuong Thung, Zhurnal Organicheskoi Khimii, 1988, 24(11), 2309-15

Production Method 6

96184-80-4

96184-81-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ,  Water ;  1 h, rt

Reference

Preparation of arylfuranone derivatives for use as antifibrotic agents

, World Intellectual Property Organization, , ,

Production Method 7

96184-80-4

96184-81-5

Reaction Conditions

1.1 Reagents: Propanal ,  Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  1 h, rt; rt → 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  30 min, rt

Reference

Preparation of nitrogen-containing bicyclic compounds

, World Intellectual Property Organization, , ,

Production Method 8

874-61-3

96184-81-5

Reaction Conditions

1.1 Catalysts: Nickel bromide (NiBr2), trihydrate ,  4,4′-Bis(1,1-dimethylethyl)-2,2′-bipyridine Solvents: Ethyl acetate ;  10 min, rt
1.2 Reagents: 2,6-Lutidine ,  Diphenylsilane Catalysts: Dimethyl dicarbonate ,  Zinc Solvents: Ethyl acetate ;  15 min, rt; 24 h, 40 °C; cooled

Reference

Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes

Iosub, Andrei V. ; Moravcik, Stefan; Wallentin, Carl-Johan; Bergman, Joakim, Organic Letters, 2019, 21(19), 7804-7808

Production Method 9

93245-98-8

96184-81-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water

Reference

Synthesis of biological activities of tetrahydroquinazoline analogs of aminopterin and methotrexate

Gangjee, Aleem; Zaveri, Nurulain; Queener, Sherry F.; Kisliuk, Roy L., Journal of Heterocyclic Chemistry, 1995, 32(1),

Production Method 10

94458-92-1

96184-81-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  2 h, rt

Reference

Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4'-oxocyclohexyl)acetonitrile as the model

Avi, Manuela; Wiedner, Romana M.; Griengl, Herfried; Schwab, Helmut, Chemistry - A European Journal, 2008, 14(36), 11415-11422

4-Oxocyclohexanecarbaldehyde Raw materials

• 4-TRIMETHYLSILANYLOXY-CYCLOHEX-3-ENE-CARBALDEHYDE
• 4-(Hydroxymethyl)cyclohexanone
• 4-oxocyclohexane-1-carboxylic acid
• 8-(Methoxymethylene)-1,4-dioxaspiro[4.5]decane
• Methylcyclohexane
• 1,4-Dioxaspiro[4.5]decane-8-carbaldehyde

4-Oxocyclohexanecarbaldehyde Preparation Products

• 4-Oxocyclohexanecarbaldehyde (96184-81-5)
• cis-3-methylcyclohexan-1-ol (5454-79-5)
• cis-4-Methylcyclohexanol (7731-28-4)
• 3-oxocyclohexane-1-carbaldehyde (69814-26-2)
• trans-3-methylcyclohexan-1-ol (7443-55-2)
• cis-2-Methylcyclohexanol (7443-70-1)
• trans-2-Methylcyclohexanol (7443-52-9)
• cyclohexanecarbaldehyde (2043-61-0)
• Cyclohexanemethanol (100-49-2)
• 1-Methylcyclohexanol (590-67-0)
• trans-4-Methylcyclohexanol (7731-29-5)
• 2-oxocyclohexanecarbaldehyde (1193-63-1)

• 1. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 53288-40-7(Cyclohexanone, 2,5-dimethyl-, trans-(+)-)
• 50615-08-2(Cyclohexanone, 2,2'-butylidenebis-)
• 20474-48-0(3-Pentanone, 2-cyclohexyl-4-methyl-)
• 3313-60-8(Cyclohexanone, 2-heptyl-4-methyl-)
• 52690-71-8([1,1'-Bicyclohexyl]-2,2'-dione, (R*,S*)-)
• 264208-61-9(Cyclohexanone, 3-(1-methyl-2-oxobutyl)-)
• 56620-97-4(Cyclohexanone, 3-butyl-2-methyl-)
• 26854-21-7(Naphthalenone, octahydro-)
• 199188-13-1(Tricyclo[5.3.1.13,9]dodecane-2,8-dione, 5-methyl-)
• 26451-31-0(Tricyclo[3.3.1.13,7]decanone, 4-methyl-)