Production Method 1

8068-05-1

2722-36-3

589-18-4

122-03-2

768-59-2

122-97-4

622-96-8

104-87-0

100-51-6

4170-90-5

Reaction Conditions

1.1 Catalysts: Molybdenum carbide (Mo2C) Solvents: Ethanol ;  3 h, 280 °C

Reference

Supported β-Mo2C on Carbon Materials for Kraft Lignin Decomposition into Aromatic Monomers in Ethanol

Wu, Kejing; Wang, Junbo; Zhu, Yingming ; Wang, Xueting; Yang, Chunyan; et al, Industrial & Engineering Chemistry Research, 2019, 58(28), 12602-12610

Production Method 2

8068-05-1

2722-36-3

589-18-4

5870-68-8

106-32-1

2082-61-3

2351-90-8

617-29-8

1117-65-3

104-87-0

544-12-7

2305-21-7

1552-67-6

100-51-6

2396-83-0

4170-90-5

Reaction Conditions

1.1 Catalysts: Molybdenum carbide ,  Molybdenum dioxide Solvents: Ethanol ;  rt → 280 °C; 3 h, 280 °C

Reference

Synthesis-Controlled α- and β-Molybdenum Carbide for Base-Promoted Transfer Hydrogenation of Lignin to Aromatic Monomers in Ethanol

Wu, Kejing; Yang, Chunyan; Zhu, Yingming ; Wang, Junbo; Wang, Xueting; et al, Industrial & Engineering Chemistry Research, 2019, 58(44), 20270-20281

3-PHENYL-1-BUTANOL Raw materials

• Sulfate Lignin

3-PHENYL-1-BUTANOL Preparation Products

• 4-Methylbenzyl alcohol (589-18-4)
• Ethyl 3-Methylvalerate (5870-68-8)
• Ethyl n-Caprylate (106-32-1)
• 4-Isopropylbenzaldehyde (122-03-2)
• (but-2-en-2-yl)benzene (2082-61-3)
• 2-Octenoic acid, ethylester (2351-90-8)
• 4-Ethylbenzyl alcohol (768-59-2)
• 3-Phenyl-1-propanol (122-97-4)
• 2-Methyl-3-hexanol (617-29-8)
• 3-Octenoic acid, ethylester (1117-65-3)
• 4-Ethyltoluene (622-96-8)
• 3-PHENYL-1-BUTANOL (2722-36-3)
• 4-Methylbenzaldehyde (104-87-0)
• 3-Hexen-1-ol (544-12-7)
• 2-Hexen-1-ol (2305-21-7)
• 2-Hexenoic acid, ethylester (1552-67-6)
• Benzyl alcohol (100-51-6)
• Ethyl hex-3-enoate (2396-83-0)
• 2,4,6-Trimethylbenzyl alcohol (4170-90-5)

• 1. Enantioselective total synthesis of (S)-nakinadine B
  Yuvraj Garg,Satyendra Kumar Pandey RSC Adv. 2016 6 25913
• 2. Acid promoted cyclodehydration of amino alcohols with amide acetal
  Soonho Hwang,Heemin Park,Yongseok Kwon,Sanghee Kim RSC Adv. 2014 4 60017
• 3. Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem
  Shane M. McKenna,Silke Leimkühler,Susanne Herter,Nicholas J. Turner,Andrew J. Carnell Green Chem. 2015 17 3271
• 4. SuperQuat N-acyl-5,5-dimethyloxazolidin-2-ones for the asymmetric synthesis of α-alkyl and β-alkyl aldehydes
  Steven D. Bull,Stephen G. Davies,Rebecca L. Nicholson,Hitesh J. Sanganee,Andrew D. Smith Org. Biomol. Chem. 2003 1 2886
• 5. Expanding plastics recycling technologies: chemical aspects, technology status and challenges
  Houqian Li,Horacio A. Aguirre-Villegas,Robert D. Allen,Xianglan Bai,Craig H. Benson,Gregg T. Beckham,Sabrina L. Bradshaw,Jessica L. Brown,Robert C. Brown,Victor S. Cecon,Julia B. Curley,Greg W. Curtzwiler,Son Dong,Soumika Gaddameedi,John E. García,Ive Hermans,Min Soo Kim,Jiaze Ma,Lesli O. Mark,Manos Mavrikakis,Olumide O. Olafasakin,Tim A. Osswald,Konstantinos G. Papanikolaou,Harish Radhakrishnan,Marco Antonio Sanchez Castillo,Kevin L. Sánchez-Rivera,Khairun N. Tumu,Reid C. Van Lehn,Keith L. Vorst,Mark M. Wright,Jiayang Wu,Victor M. Zavala,Panzheng Zhou,George W. Huber Green Chem. 2022 24 8899

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives

Chemical Profile of 3-PHENYL-1-BUTANOL (CAS No. 2722-36-3)

3-PHENYL-1-BUTANOL, with the chemical formula C₉H₁₂O, is a significant organic compound widely recognized for its utility in pharmaceutical synthesis, flavor and fragrance production, and as an intermediate in various chemical processes. The compound’s molecular structure, featuring a phenyl group attached to a butyl chain, imparts unique chemical properties that make it valuable in multiple industrial applications. This introduction delves into the compound’s characteristics, synthesis methods, industrial applications, and recent advancements in its utilization within the pharmaceutical sector.

The CAS No. 2722-36-3 identifier is a standardized registration number assigned to this specific chemical entity, ensuring unambiguous identification in scientific literature and commercial transactions. The compound is classified as an alcohol derivative, exhibiting both alcoholic and aromatic characteristics due to the presence of the hydroxyl (-OH) group and the phenyl ring. These structural features contribute to its solubility in organic solvents and its reactivity in various chemical transformations.

Synthesis of 3-PHENYL-1-BUTANOL typically involves the reaction of phenylacetaldehyde with butanol or through catalytic hydrogenation of corresponding unsaturated precursors. Advanced synthetic methodologies have been developed to enhance yield and purity, including enzymatic catalysis and flow chemistry techniques. These innovations align with the growing demand for sustainable and efficient production processes in the chemical industry.

In the pharmaceutical domain, 3-PHENYL-1-BUTANOL serves as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its aromatic moiety allows for further functionalization, enabling the creation of complex molecular architectures essential for drug development. Recent studies have highlighted its role in producing novel therapeutic agents targeting neurological disorders, where the phenyl group enhances binding affinity to specific biological receptors.

One notable application of 3-PHENYL-1-BUTANOL is in the development of neurological therapeutics. Researchers have utilized derivatives of this compound to design molecules that modulate neurotransmitter activity. For instance, modifications to the butyl chain have led to compounds with improved blood-brain barrier penetration, a critical factor for effective central nervous system (CNS) drug delivery. These findings underscore the compound’s potential in addressing conditions such as epilepsy and Alzheimer’s disease.

The fragrance and flavor industry also leverages 3-PHENYL-1-BUTANOL due to its aromatic profile, which contributes to pleasant olfactory experiences. Its use in perfumes and food additives is governed by stringent safety guidelines to ensure consumer protection. The compound’s stability under various conditions makes it a preferred choice for formulating long-lasting scents and flavors.

From an environmental perspective, efforts are underway to optimize the production and disposal of 3-PHENYL-1-BUTANOL to minimize ecological impact. Green chemistry principles are being applied to develop biodegradable derivatives and eco-friendly synthesis routes. Such initiatives are vital for aligning industrial practices with global sustainability goals.

Future research directions for 3-PHENYL-1-BUTANOL include exploring its applications in material science, particularly as a precursor for high-performance polymers. The compound’s ability to form stable cross-linked networks suggests potential use in coatings and adhesives requiring enhanced durability and chemical resistance. Additionally, its role in nanotechnology is being investigated for developing novel drug delivery systems based on organic-inorganic hybrids.

In conclusion, 3-PHENYL-1-BUTANOL (CAS No. 2722-36-3) is a versatile compound with broad industrial relevance. Its unique structural properties enable diverse applications ranging from pharmaceuticals to fragrances and advanced materials. As scientific understanding advances, new opportunities for utilizing this compound are likely to emerge, reinforcing its importance in modern chemistry.

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