Acid promoted cyclodehydration of amino alcohols with amide acetal?
RSC Advances Pub Date: 2014-11-06 DOI: 10.1039/C4RA10625C
Abstract
A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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