Production Method 1

8068-05-1

122-97-4

589-18-4

122-03-2

768-59-2

622-96-8

2722-36-3

104-87-0

100-51-6

4170-90-5

100-52-7

933-98-2

4748-78-1

Reaction Conditions

1.1 Catalysts: Molybdenum carbide (Mo2C) Solvents: Ethanol ;  3 h, 280 °C

Reference

Supported β-Mo2C on Carbon Materials for Kraft Lignin Decomposition into Aromatic Monomers in Ethanol

Wu, Kejing; Wang, Junbo; Zhu, Yingming ; Wang, Xueting; Yang, Chunyan; et al, Industrial & Engineering Chemistry Research, 2019, 58(28), 12602-12610

3-Phenyl-1-propanol Raw materials

• Sulfate Lignin

3-Phenyl-1-propanol Preparation Products

• 4-Methylbenzyl alcohol (589-18-4)
• 4-Isopropylbenzaldehyde (122-03-2)
• 4-Ethylbenzyl alcohol (768-59-2)
• 3-Phenyl-1-propanol (122-97-4)
• 4-Ethyltoluene (622-96-8)
• 3-PHENYL-1-BUTANOL (2722-36-3)
• 4-Methylbenzaldehyde (104-87-0)
• Benzyl alcohol (100-51-6)
• 2,4,6-Trimethylbenzyl alcohol (4170-90-5)
• Benzaldehyde (100-52-7)
• 1-Ethyl-2,3-dimethylbenzene (933-98-2)
• 4-Ethylbenzaldehyde (4748-78-1)

• 1. Effective 1,5-, 1,6- and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes
  John S. Carey,Somhairle MacCormick,Steven J. Stanway,Aphiwat Teerawutgulrag,Eric J. Thomas Org. Biomol. Chem. 2011 9 3896
• 2. Effective 1,5-, 1,6- and 1,7-remote stereocontrol in reactions of alkoxy- and hydroxy-substituted allylstannanes with aldehydes
  John S. Carey,Somhairle MacCormick,Steven J. Stanway,Aphiwat Teerawutgulrag,Eric J. Thomas Org. Biomol. Chem. 2011 9 3896
• 3. Oxidation of cinnamyl alcohol using bimetallic Au–Pd/TiO2 catalysts: a deactivation study in a continuous flow packed bed microreactor
  Gaowei Wu,Gemma L. Brett,Enhong Cao,Achilleas Constantinou,Peter Ellis,Simon Kuhn,Graham J. Hutchings,Donald Bethell,Asterios Gavriilidis Catal. Sci. Technol. 2016 6 4749
• 4. Platinum-catalysed cinnamaldehyde hydrogenation in continuous flow
  Lee J. Durndell,Karen Wilson,Adam F. Lee RSC Adv. 2015 5 80022
• 5. Towards greener solvents for the bleach oxidation of alcohols catalysed by stable N-oxy radicals
  Michiel H. A. Janssen,Juan F. Chesa Castellana,Hayley Jackman,Peter J. Dunn,Roger A. Sheldon Green Chem. 2011 13 905

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Introduction to 3-Phenyl-1-propanol (CAS No: 122-97-4)

3-Phenyl-1-propanol, with the chemical formula C?H??O and CAS number 122-97-4, is an organic compound that has garnered significant attention in the field of pharmaceuticals, fragrances, and specialty chemicals. This compound, characterized by its phenyl and alcohol functional groups, exhibits a range of properties that make it valuable in various industrial and research applications. The molecular structure of 3-Phenyl-1-propanol consists of a phenyl ring attached to a propyl chain with an alcohol (-OH) group at the terminal carbon. This configuration imparts both aromatic and aliphatic characteristics, enabling diverse chemical interactions and reactivities.

The synthesis of 3-Phenyl-1-propanol can be achieved through several routes, including Grignard reactions, hydroformylation of phenylacetylene, or reduction of corresponding esters. Among these methods, the Grignard reaction involving phenylmagnesium bromide and propionaldehyde is particularly noteworthy for its efficiency and yield. This approach highlights the compound's versatility in synthetic chemistry, making it a preferred choice for researchers seeking to develop derivatives with tailored properties.

In recent years, 3-Phenyl-1-propanol has been extensively studied for its potential applications in pharmaceuticals. Its structural motif is reminiscent of many bioactive molecules, suggesting possible roles in drug design and development. For instance, derivatives of 3-Phenyl-1-propanol have been investigated as intermediates in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents. The presence of both the phenyl ring and the hydroxyl group allows for further functionalization, enabling the creation of complex molecules with enhanced pharmacological profiles.

One of the most compelling aspects of 3-Phenyl-1-propanol is its role in fragrance chemistry. The compound possesses a fruity, floral aroma that makes it a popular ingredient in perfumes, soaps, and cosmetics. Its olfactory properties are attributed to the interaction between the phenyl group and the alcohol moiety, which together contribute to a pleasant scent profile. Moreover, the compound's stability under various conditions enhances its appeal as a fragrance component in commercial products.

Recent advancements in green chemistry have also highlighted the significance of 3-Phenyl-1-propanol as a sustainable building block. Researchers have explored biocatalytic routes to produce this compound using enzymes such as alcohol dehydrogenases and ketoreductases. These biocatalytic methods offer several advantages over traditional synthetic routes, including higher selectivity, milder reaction conditions, and reduced environmental impact. Such innovations align with global efforts to promote eco-friendly chemical processes.

The pharmaceutical industry has been particularly interested in exploring the potential of 3-Phenyl-1-propanol as a precursor for drug candidates. Studies have demonstrated its utility in synthesizing molecules with anti-inflammatory, analgesic, and even anticancer properties. The compound's ability to undergo further derivatization allows chemists to modify its structure systematically. For example, esterification or etherification of 3-Phenyl-1-propanol can yield novel compounds with distinct biological activities. This flexibility underscores its importance as a versatile intermediate in medicinal chemistry.

Another area where 3-Phenyl-1-propanol has shown promise is in material science. Its unique combination of hydrophobic (phenyl ring) and hydrophilic (alcohol group) characteristics makes it suitable for applications in polymer chemistry and surface modifications. Researchers have incorporated 3-Phenyl-1-propanol into polymeric materials to enhance their thermal stability and mechanical properties. Additionally, the compound's ability to act as a chelating agent has been exploited in metal ion sequestration studies.

The spectroscopic properties of 3-Phenyl-1-propanol have also been thoroughly examined by scientists. Nuclear magnetic resonance (NMR) spectroscopy reveals detailed information about its molecular structure, while infrared (IR) spectroscopy helps identify functional groups present in the molecule. These analytical techniques are crucial for confirming the identity and purity of 3-Phenyl-1-propanol, ensuring its suitability for various applications.

In conclusion,3-Phenyl-1-propanol (CAS No: 122-97-4) is a multifaceted compound with significant implications across multiple scientific disciplines. Its role in pharmaceutical synthesis, fragrance formulation, green chemistry initiatives, and material science underscores its versatility and importance. As research continues to uncover new applications for this compound,3 Phenyl 1 propanol is poised to remain a key player in both academic and industrial settings.

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