Enantioselective total synthesis of (S)-nakinadine B??
RSC Advances Pub Date: 2016-03-03 DOI: 10.1039/C6RA03915D
Abstract
A novel approach for the synthesis of α-phenyl-β2-amino acid core unit 1 and its application to the total synthesis of (S)-nakinadine B 3, a marine natural product, is described. The synthesis utilizes the optimized combination of diphenylprolinol silyl ether mediated asymmetric Michael addition and a proline catalyzed aminoxylation reactions as key steps.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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