Production Method 1

10549-76-5

2146-07-8

823-85-8

332-07-0

20893-71-4

Reaction Conditions

1.1 Reagents: Deuterium chloride Solvents: Acetonitrile-d3 ,  Water-d2

Reference

The Trapping of Phenyldiazenes in Cycloaddition Reactions

Fehler, Stefanie K.; et al, Angewandte Chemie, 2014, 53(42), 11361-11365

Production Method 2

2146-07-8

823-85-8

332-07-0

20893-71-4

Reaction Conditions

1.1 Reagents: Tetrabutylammonium hydroxide Solvents: Acetonitrile-d3 ,  Water-d2
2.1 Reagents: Deuterium chloride Solvents: Acetonitrile-d3 ,  Water-d2

Reference

The Trapping of Phenyldiazenes in Cycloaddition Reactions

Fehler, Stefanie K.; et al, Angewandte Chemie, 2014, 53(42), 11361-11365

Benzenamine, 4-fluoro-,hydrochloride (1:1) Raw materials

• Tetrabutylammonium bromide

Benzenamine, 4-fluoro-,hydrochloride (1:1) Preparation Products

• (4-fluorophenyl)hydrazine hydrochloride (823-85-8)
• Benzenamine, 4-fluoro-,hydrochloride (1:1) (2146-07-8)
• azobenzene, 4,4'-difluoro- (332-07-0)
• Benzenediazonium, 4-fluoro-, chloride (20893-71-4)

• 1. Reduction of aromatic and aliphatic nitro groups to anilines and amines with hypophosphites associated with Pd/C
  Marc Baron,Estelle Métay,Marc Lemaire,Florence Popowycz Green Chem. 2013 15 1006

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines

Benzenamine, 4-fluoro-, hydrochloride (1:1) and Its Significance in Modern Chemical Research

Benzenamine, 4-fluoro-, hydrochloride (1:1), with the CAS number 2146-07-8, is a fluorinated aromatic amine derivative that has garnered significant attention in the field of pharmaceutical and chemical research. This compound, characterized by its hydrochloride salt form, exhibits unique chemical properties that make it a valuable intermediate in the synthesis of various biologically active molecules. The presence of a fluorine atom at the para position relative to the amino group enhances its reactivity and stability, making it a preferred choice for researchers exploring novel therapeutic agents.

The< strong>4-fluoro- substituent in< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) imparts specific electronic and steric effects that influence its interactions with biological targets. Fluorine atoms are known to modulate the pharmacokinetic properties of molecules, often improving their metabolic stability and binding affinity. This has led to extensive studies on fluorinated amines in drug discovery, where< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) plays a pivotal role as a building block for more complex structures.

In recent years, the pharmaceutical industry has seen a surge in the development of fluorinated compounds due to their enhanced biological activity. Researchers have leveraged the< strong>4-fluoro- group in< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) to design molecules with improved efficacy and reduced side effects. For instance, studies have demonstrated its utility in the synthesis of kinase inhibitors, which are crucial for treating cancers and inflammatory diseases. The ability of< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) to act as a precursor for these inhibitors underscores its importance in medicinal chemistry.

The< strong>hydrochloride (1:1) form of this compound ensures high solubility and stability, which are essential for both laboratory research and potential clinical applications. The hydrochloride salt enhances the compound's bioavailability, making it more suitable for in vivo studies. This property has been particularly beneficial in preclinical trials where accurate dosing and formulation are critical.

Advances in computational chemistry have further highlighted the potential of< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) . Molecular modeling studies have revealed that the< strong>4-fluoro- group optimizes interactions with target proteins by improving hydrogen bonding networks and reducing unfavorable steric clashes. These insights have guided the design of next-generation drugs with enhanced target specificity. Additionally, computational approaches have been used to predict metabolic pathways and potential side effects associated with< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) , aiding in the development of safer therapeutic agents.

The role of< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) in material science is also noteworthy. Fluorinated aromatic amines are increasingly being explored for their applications in organic electronics and advanced materials. The electron-withdrawing nature of the< strong>4-fluoro- group influences charge transport properties, making this compound a candidate for use in semiconductors and light-emitting diodes (LEDs). Research in this area continues to expand, demonstrating the versatility of< strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) .

In conclusion, < strong>Benzenamine, 4-fluoro-, hydrochloride (1:1) CAS no2146-07-8 represents a cornerstone compound in modern chemical research. Its unique structural features and functional properties make it indispensable in pharmaceutical development, material science, and beyond. As research progresses, the applications of this compound are expected to grow further, solidifying its position as a key player in scientific innovation.

• 71744-89-3(Platinum,dichlorobis(3-fluorobenzenamine)-, (SP-4-2)- (9CI))
• 1398065-56-9(3-Fluoroaniline-d5)
• 1993-09-5(3-Fluorophenylamine hydrochloride)
• 84152-22-7(Platinum,dichlorobis(4-fluorobenzenamine)-, (SP-4-2)- (9CI))
• 13916-91-1(6-Fluoronaphthalen-2-amine)
• 372-39-4(3,5-Difluoroaniline)
• 76085-46-6(Benzenamine, 4-fluoro-, monolithium salt)
• 372-41-8(5-fluorobenzene-1,3-diamine)
• 62078-76-6(2-Naphthalenamine,7-fluoro-(9CI))
• 51085-49-5(2-FLUOROANILINE HYDROCHLORIDE)