• 1. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 2. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453
• 3. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 4. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 5. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789

Comprehensive Overview of 5-Fluorobenzene-1,3-diamine (CAS No. 372-41-8): Properties, Applications, and Industry Trends

5-Fluorobenzene-1,3-diamine (CAS No. 372-41-8), also known as 1,3-diamino-5-fluorobenzene, is a fluorinated aromatic diamine compound with significant relevance in pharmaceutical, agrochemical, and material science industries. Its molecular structure, featuring both amino and fluorine functional groups, enables unique reactivity and versatility in synthetic applications. This article delves into its chemical properties, industrial uses, and emerging trends aligned with current market demands, such as green chemistry and sustainable synthesis.

The compound's CAS registry number 372-41-8 serves as a critical identifier for researchers and regulatory bodies. With a molecular formula of C₆H₇FN₂, it exhibits a molar mass of 126.13 g/mol and typically appears as a light-colored crystalline solid. Its fluorine substitution enhances electron-withdrawing effects, influencing its reactivity in nucleophilic aromatic substitution (SNAr) reactions—a topic frequently searched by organic chemists exploring heterocyclic compound synthesis.

In pharmaceuticals, 5-fluorobenzene-1,3-diamine acts as a key intermediate for anticancer agents and antiviral drugs, reflecting the growing interest in precision medicine and targeted therapies. Recent studies highlight its role in developing kinase inhibitors, a hot topic in oncology research. The compound's bioisosteric potential (often queried in AI-driven drug discovery platforms) makes it valuable for optimizing drug bioavailability and metabolic stability.

Material scientists leverage this diamine for synthesizing high-performance polymers, including polyimides and epoxy resins, which are essential for aerospace and electronics applications. Searches for heat-resistant polymers and flexible electronics materials have surged, aligning with the compound's utility in these domains. Its incorporation into covalent organic frameworks (COFs) also addresses the demand for porous materials in gas storage and catalysis.

Environmental considerations drive innovations in the synthesis of 372-41-8. Researchers are exploring catalytic fluorination methods and solvent-free reactions to reduce waste—a response to the popularity of search terms like eco-friendly chemical synthesis. Regulatory compliance with REACH and FDA guidelines further underscores the need for sustainable production practices.

Analytical techniques for characterizing 5-fluorobenzene-1,3-diamine include HPLC, GC-MS, and NMR spectroscopy, with ¹⁹F-NMR being particularly useful due to the fluorine atom. These methods are frequently discussed in forums on chemical purity standards, another trending topic among quality control professionals.

In summary, CAS No. 372-41-8 represents a multifaceted compound bridging diverse scientific disciplines. Its applications in drug development, advanced materials, and green chemistry position it at the forefront of industrial and academic research, answering the call for innovative solutions in a rapidly evolving technological landscape.

• 372-39-4(3,5-Difluoroaniline)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)