A metal-free approach to highly functionalized 3-substituted-3-arylbenzofuran-2(3H)-ones?
New Journal of Chemistry Pub Date: 2022-10-25 DOI: 10.1039/D2NJ03404B
Abstract
A novel metal-free approach to the synthesis of a variety of 3-substituted-3-arylbenzofuran-2(3H)-ones is developed via H2SO4-mediated dehydrative substitution of 3-hydroxy-3-phenylbenzofuran-2(3H)-ones with electron-rich arenes/1,3-diones/alcohols/thiols as nucleophiles in moderate to good yields. Mechanistically, the substitution with the alkoxy group proceeds via a phenolic–hydroxyester intermediate, and forms the desired product via cascade dehydration–relactonization steps.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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