Water-mediated decarboxylative radical nitrosation of β-keto acids with tert-butyl nitrite: access to α-oximino ketones?
New Journal of Chemistry Pub Date: 2022-10-24 DOI: 10.1039/D2NJ04175H
Abstract
A practical catalyst-free decarboxylative radical nitrosation reaction of β-keto acids with tert-butyl nitrite in water was developed. The strategy involving radicals worked well under relatively mild conditions. This protocol presented an efficient route for the construction of various aromatic and aliphatic α-oximino ketones with different electronic and steric properties in good to excellent yields (up to 95%).
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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