An improved two-step synthetic route to primary allylic alcohols from aldehydes?

New Journal of Chemistry Pub Date: 2010-01-12 DOI: 10.1039/B9NJ00710E

Abstract

An improved two-step synthetic route to allylic alcohols from aldehydes has been developed. A modification of the HWE reaction in H2O–2-PrOH (1 ∶ 1) and a convenient protocol to prepare AlH3 in THF from LiAlH4 and n-BuBr are the key factors in the improvement.

Graphical abstract: An improved two-step synthetic route to primary allylic alcohols from aldehydes
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