Palladium-catalyzed C–H trifluoromethylselenolation of arenes with [Me4N][SeCF3] and an oxidant?
Chemical Communications Pub Date: 2022-07-18 DOI: 10.1039/D2CC02897B
Abstract
Trifluoromethylselenolation of arenes with [Me4N][SeCF3] in the presence of an oxidant through Pd-catalyzed C(sp2)–H activation under the assistance of a directing group is established for the first time. The reaction tolerates different directing groups and a variety of functional groups, enabling selective installation of a SeCF3 moiety onto the ortho positions of arenes. Mechanistic studies revealed that the CF3SeSeCF3 intermediate in situ generated from oxidation of [Me4N][SeCF3] might be the real SeCF3 reagent in the reaction.
![Graphical abstract: Palladium-catalyzed C–H trifluoromethylselenolation of arenes with [Me4N][SeCF3] and an oxidant](http://scimg.chem960.com/usr/1/D2CC02897B.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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