Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase?
RSC Medicinal Chemistry Pub Date: 2020-10-19 DOI: 10.1039/D0MD00301H
Abstract
Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of Mycobacterium tuberculosis. Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and provide insights into the catalytic mechanism of ICLs.
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Journal Name：RSC Medicinal Chemistry
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CAS no.: 89640-58-4
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