Synthesis and properties of MIDA boronate containing aromatic amino acids: New peptide building blocks?

Organic & Biomolecular Chemistry Pub Date: 2011-01-31 DOI: 10.1039/C0OB00847H

Abstract

Herein, we report the synthesis of novel phenylalanine and tyrosine derivatives containing a N-methyliminodiacetic acid boronate group. These compounds can be prepared enantiomerically pure, they are stable to column chromatography and they can be stored in air for two months without degradation occurring. This new class of boronate containing aromatic amino acids has potential applications in both peptide chemistry and natural product synthesis.

Graphical abstract: Synthesis and properties of MIDA boronate containing aromatic amino acids: New peptide building blocks
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