Iodine-catalyzed oxidative functionalization of purines with (thio)ethers or methylarenes for the synthesis of purin-8-one analogues?
Organic & Biomolecular Chemistry Pub Date: 2021-05-21 DOI: 10.1039/D1OB00118C
Abstract
An efficient oxidative functionalization of purine-like substrates with (thio)ethers or methylarenes under mild conditions is described. Using I2 as the catalyst, and TBHP as the oxidant, this protocol provides a valuable synthetic tool for the assembly of a wide range of 9-alkyl(benzyl)purin-8-one derivatives with high atom- and step-economy and exceptional functional group tolerance.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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