- Preparation method of 2-amino-5-methylpyrazine from 2-aminopropanediamide and methylglyoxal, China, , ,
Cas no 98006-91-8 (5-Methylpyrazine-2-carbonitrile)
5-Methylpyrazine-2-carbonitrile is a heterocyclic organic compound featuring a pyrazine core substituted with a methyl group at the 5-position and a nitrile functional group at the 2-position. This structure imparts reactivity suitable for applications in pharmaceutical and agrochemical synthesis, particularly as a versatile intermediate in the preparation of more complex molecules. Its nitrile group enables further functionalization through hydrolysis, reduction, or cyclization reactions. The compound’s stability and well-defined reactivity profile make it valuable for research and industrial processes requiring precise molecular modifications. It is typically handled under controlled conditions due to its potential sensitivity to moisture and heat.
98006-91-8 structure
Product Name:5-Methylpyrazine-2-carbonitrile
CAS No:98006-91-8
MF:C6H5N3
MW:0
MDL:MFCD04116510
CID:654187
PubChem ID:2760047
Update Time:2025-06-07
5-Methylpyrazine-2-carbonitrile Chemical and Physical Properties
Names and Identifiers
-
- 5-Methylpyrazine-2-carbonitrile
- 5-Methyl-2-pyrazinecarbonitrile
- 5-Methyl-pyrazin-2-carbonitrile
- Pyrazinecarbonitrile, 5-methyl- (9CI)
- 2-Pyrazinecarbonitrile, 5-methyl-
- 2-Pyrazinecarbonitrile,5-methyl
- 2-Cyano-5-methylpyrazine
- 2-Methylpyrazine-5-carbonitrile
- 5-Methyl-2-cyanopyrazine
- 5-Methyl-2-pyrazinecarbonitrile (ACI)
- A1-24369
- 5-Methyl-pyrazine-2-carbonitrile
- AKOS006294411
- Z1198164470
- SY022841
- AB20698
- AYMRPLHDHGMXOF-UHFFFAOYSA-N
- 2-Methyl-5-Cyanopyrazine
- PYRAZINECARBONITRILE, 5-METHYL-
- SCHEMBL2143383
- EN300-106522
- J-517821
- MFCD04116510
- AS-42128
- DTXSID80374998
- AC-30163
- CS-0012682
- 98006-91-8
-
- MDL： MFCD04116510
- Inchi： InChI=1S/C6H5N3/c1-5-3-9-6(2-7)4-8-5/h3-4H,1H3
- InChI Key： AYMRPLHDHGMXOF-UHFFFAOYSA-N
- SMILES： CC1=NC=C(C#N)N=C1
Computed Properties
- Exact Mass: 119.04800
- Monoisotopic Mass: 119.048
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 9
- Rotatable Bond Count: 0
- Complexity: 135
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 0.3
- Topological Polar Surface Area: 49.6A^2
Experimental Properties
- Color/Form: No data avaiable
- Density: 1.16
- Melting Point: No data available
- Boiling Point: 247 oC
- Flash Point: 96 oC
- Refractive Index: 1.531
- PSA: 49.57000
- LogP: 0.65668
- Vapor Pressure: No data available
5-Methylpyrazine-2-carbonitrile Security Information
- Signal Word：Warning
- Hazard Statement： H302 (100%) H312 (100%) H315 (100%)
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： H302 (100%) H312 (100%) H315 (100%)
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
5-Methylpyrazine-2-carbonitrile Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
5-Methylpyrazine-2-carbonitrile Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 020122-250mg |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 97% | 250mg |
￡22.00 | 2022-03-01 | |
| Fluorochem | 020122-1g |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 97% | 1g |
￡48.00 | 2022-03-01 | |
| Fluorochem | 020122-5g |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 97% | 5g |
￡110.00 | 2022-03-01 | |
| Fluorochem | 020122-25g |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 97% | 25g |
￡360.00 | 2022-03-01 | |
| Alichem | A099000303-10g |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 97% | 10g |
$238.14 | 2023-08-31 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | M860394-1g |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | ≥98% | 1g |
256.50 | 2021-05-17 | |
| CHENG DOU FEI BO YI YAO Technology Co., Ltd. | ARK-0984-5g |
5-methylpyrazine-2-carbonitrile |
98006-91-8 | 95% | 5g |
$196 | 2023-09-07 | |
| TRC | M321543-50mg |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 50mg |
$ 50.00 | 2022-06-04 | ||
| TRC | M321543-100mg |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 100mg |
$ 65.00 | 2022-06-04 | ||
| TRC | M321543-500mg |
5-Methylpyrazine-2-carbonitrile |
98006-91-8 | 500mg |
$ 135.00 | 2022-06-04 |
5-Methylpyrazine-2-carbonitrile Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Triethylamine , Hydrogen Catalysts: Palladium Solvents: Methanol ; 2.0 MPa, rt → 100 °C; 10 h, 100 °C
Reference
Production Method 2
Reaction Conditions
Reference
- Product class 14: pyrazinesSato, N., Science of Synthesis, 2004, 16, 751-844
Production Method 3
Reaction Conditions
Reference
- Process for preparing heteroaromatic nitriles by ammoxidation of alkyl-substituted heteroaromatics using molybdenum-containing catalysts, European Patent Organization, , ,
Production Method 4
Reaction Conditions
Reference
- Studies on pyrazines. Part 22. Lewis acid-mediated cyanation of pyrazine N-oxides with trimethylsilyl cyanide: new route to 2-substituted 3-cyanopyrazinesSato, Nobuhiro; Shimomura, Yuji; Ohwaki, Yoshie; Takeuchi, Ryo, Journal of the Chemical Society, 1991, (1991), 2877-81
Production Method 5
Reaction Conditions
Reference
- Antituberculotics. XXXII. Functional derivatives of 5-methyl-2-pyrazinecarboxylic acidVontor, T.; Palat, K.; Oswald, J.; Odlerova, Z., Cesko-Slovenska Farmacie, 1985, 34(2), 74-8
5-Methylpyrazine-2-carbonitrile Raw materials
- 3-Methylpyrazine 1-oxide
- 3-Chloro-5-methylpyrazine-2-carbonitrile
- 2,5-Dimethylpyrazine
- trimethylsilanecarbonitrile
5-Methylpyrazine-2-carbonitrile Preparation Products
5-Methylpyrazine-2-carbonitrile Suppliers
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:98006-91-8)5-Methylpyrazine-2-carbonitrile
Order Number:A856055
Stock Status:in Stock
Quantity:25g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 07:58
Price ($):211.0/153.0
Email:[email protected]
5-Methylpyrazine-2-carbonitrile Related Literature
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Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
-
Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
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Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
-
Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
-
5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
98006-91-8 (5-Methylpyrazine-2-carbonitrile) Related Products
- 40227-17-6(2,3-Pyrazinedicarbonitrile,5,6-dimethyl-)
- 52197-12-3(5-Methylpyrazine-2,3-dicarbonitrile)
- 31722-48-2(2,5-dcpz)
- 19847-12-2(pyrazine-2-carbonitrile)
- 65735-15-1(3-methylpyrazine-2-carbonitrile)
- 2435-47-4(3,6-Dimethylpyrazine-2-carbonitrile)
- 861554-17-8(2,5-Pyrazinedicarbonitrile,3,6-dimethyl-)
- 13481-25-9(Pyrazine-2,3-dicarbonitrile)
- 33420-37-0(Pyrazine-2,3,5,6-tetracarbonitrile)
- 136309-04-1(6-Methylpyrazine-2-carbonitrile)
Recommended suppliers
Amadis Chemical Company Limited
(CAS:98006-91-8)5-Methylpyrazine-2-carbonitrile
Purity:99%/99%
Quantity:25g/5g
Price ($):211.0/153.0