• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrazines

Comprehensive Overview of 6-Methylpyrazine-2-carbonitrile (CAS No. 136309-04-1): Properties, Applications, and Industry Trends

6-Methylpyrazine-2-carbonitrile (CAS No. 136309-04-1) is a specialized organic compound belonging to the pyrazine family, characterized by its unique nitrile-functionalized pyrazine core and a methyl substituent at the 6-position. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its versatile heterocyclic scaffold, which serves as a key intermediate in synthesizing bioactive molecules. The growing demand for pyrazine derivatives in drug discovery, coupled with advancements in green chemistry methodologies, has positioned this compound as a subject of interest for researchers exploring sustainable synthetic routes.

In recent years, the scientific community has focused on optimizing the synthesis of 6-Methylpyrazine-2-carbonitrile to improve yield and purity while reducing environmental impact. Studies highlight its role in developing flavor and fragrance ingredients, where pyrazine derivatives contribute to roasted or nutty sensory profiles. Additionally, its electron-deficient aromatic system makes it valuable in materials science, particularly in designing organic semiconductors and photovoltaic materials. These applications align with global trends toward renewable energy and functional materials, addressing frequent search queries like "pyrazine applications in electronics" or "nitrile-containing heterocycles in drug design."

The physicochemical properties of CAS No. 136309-04-1 include a molecular weight of 133.15 g/mol and a melting point range of 80–85°C, as documented in technical literature. Its solubility in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO) facilitates its use in cross-coupling reactions, a topic frequently searched by synthetic chemists. Analytical techniques such as HPLC and GC-MS are commonly employed to verify its purity, reflecting industry standards for high-precision intermediates. Regulatory databases classify this compound as non-hazardous under normal handling conditions, though standard laboratory precautions are recommended.

Market analyses indicate rising interest in 6-Methylpyrazine-2-carbonitrile as a building block for crop protection agents, driven by the agrochemical sector's need for novel modes of action. Patent reviews reveal its incorporation into fungicides and herbicides, resonating with search trends such as "pyrazine-based agrochemicals 2024." Furthermore, its potential in metal-organic frameworks (MOFs) has been explored, linking to trending topics like "porous materials for gas storage." Such multidisciplinary applications underscore its relevance in both academic and industrial settings.

To address common user queries about stability, 6-Methylpyrazine-2-carbonitrile exhibits excellent shelf life when stored in airtight containers under inert atmospheres, a detail often sought by procurement specialists. Suppliers increasingly emphasize batch-to-batch consistency and regulatory compliance, reflecting heightened quality expectations in fine chemical markets. Future research directions may explore its enantioselective transformations or catalytic modifications, aligning with the broader shift toward atom-efficient synthesis—a hot topic in sustainable chemistry forums.

• 40227-17-6(2,3-Pyrazinedicarbonitrile,5,6-dimethyl-)
• 52197-12-3(5-Methylpyrazine-2,3-dicarbonitrile)
• 31722-48-2(2,5-dcpz)
• 19847-12-2(pyrazine-2-carbonitrile)
• 65735-15-1(3-methylpyrazine-2-carbonitrile)
• 2435-47-4(3,6-Dimethylpyrazine-2-carbonitrile)
• 70911-23-8(2,6-pyrazinedicarbonitrile)
• 861554-17-8(2,5-Pyrazinedicarbonitrile,3,6-dimethyl-)
• 13481-25-9(Pyrazine-2,3-dicarbonitrile)
• 33420-37-0(Pyrazine-2,3,5,6-tetracarbonitrile)