• 1. Structural factors influencing the intramolecular charge transfer and photoinduced electron transfer in tetrapyrazinoporphyrazines
  Veronika Novakova,Petr Hladík,Tereza Filandrová,Ivana Zajícová,Veronika Krepsová,Miroslav Miletin,Juraj Len?o,Petr Zimcik Phys. Chem. Chem. Phys. 2014 16 5440
• 2. Structural elaboration of dicyanopyrazine: towards push–pull molecules with tailored photoredox activity
  Zuzana Hlou?ková,Milan Klikar,Old?ich Pytela,Numan Almonasy,Ale? R??i?ka,Veronika Jandová,Filip Bure? RSC Adv. 2019 9 23797
• 3. A novel 9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile end group for an efficient non-fullerene small molecule acceptor
  Wei Gao,Miao Zhang,Zhanxiang Chen,Xiaohui Liu,Kailu Zheng,Cheng Zhong,Fujun Zhang,Chuluo Yang J. Mater. Chem. C 2019 7 10111
• 4. The effect of the number of carbohydrate moieties on the azaphthalocyanine properties
  Veronika Novakova,Rabia Zeynep Uslu Kobak,Radim Ku?era,Kamil Kopecky,Miroslav Miletin,Veronika Krepsová,Jana Ivincová,Petr Zimcik Dalton Trans. 2012 41 10596
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  Antonin Cidlina,Veronika Novakova,Miroslav Miletin,Petr Zimcik Dalton Trans. 2015 44 6961

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrazines
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Recent Advances in the Study of Pyrazine-2,3-dicarbonitrile (CAS 13481-25-9) in Chemical Biology and Pharmaceutical Research

Pyrazine-2,3-dicarbonitrile (CAS 13481-25-9) is a heterocyclic compound that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a key intermediate in the synthesis of various biologically active molecules, including kinase inhibitors, antimicrobial agents, and fluorescent probes. Recent studies have further elucidated its potential in drug discovery and development, particularly in targeting protein-protein interactions and modulating enzymatic activity.

One of the most notable advancements in the study of Pyrazine-2,3-dicarbonitrile is its role in the development of novel kinase inhibitors. Kinases are critical regulators of cellular signaling pathways, and their dysregulation is implicated in numerous diseases, including cancer and inflammatory disorders. Researchers have demonstrated that derivatives of Pyrazine-2,3-dicarbonitrile exhibit potent inhibitory activity against specific kinases, such as JAK2 and EGFR, which are prominent targets in oncology. These findings highlight the compound's potential as a scaffold for designing next-generation kinase inhibitors with improved selectivity and efficacy.

In addition to its applications in kinase inhibition, Pyrazine-2,3-dicarbonitrile has been explored for its antimicrobial properties. Recent studies have shown that certain derivatives of this compound exhibit broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as well as fungal pathogens. The mechanism of action appears to involve disruption of microbial cell membranes and interference with essential metabolic pathways. These results suggest that Pyrazine-2,3-dicarbonitrile-based compounds could serve as promising candidates for the development of new antimicrobial agents, particularly in the face of rising antibiotic resistance.

Another exciting area of research involves the use of Pyrazine-2,3-dicarbonitrile as a building block for fluorescent probes. Due to its unique electronic properties, this compound can be functionalized to produce highly sensitive and selective fluorescent sensors for detecting metal ions, reactive oxygen species, and other biologically relevant molecules. Recent work has demonstrated the utility of such probes in live-cell imaging and diagnostic applications, offering new tools for studying cellular processes and disease mechanisms.

Despite these promising developments, challenges remain in the optimization of Pyrazine-2,3-dicarbonitrile-based compounds for clinical use. Issues such as solubility, bioavailability, and off-target effects need to be addressed through further structural modification and formulation studies. Nevertheless, the growing body of research underscores the potential of this compound as a valuable asset in the toolkit of medicinal chemists and drug developers.

In conclusion, Pyrazine-2,3-dicarbonitrile (CAS 13481-25-9) continues to be a focal point of innovation in chemical biology and pharmaceutical research. Its diverse applications, ranging from kinase inhibition to antimicrobial activity and fluorescent probe development, highlight its versatility and potential for addressing unmet medical needs. As research progresses, it is anticipated that new derivatives and formulations of this compound will emerge, further expanding its utility in both basic science and therapeutic applications.

• 40227-17-6(2,3-Pyrazinedicarbonitrile,5,6-dimethyl-)
• 52197-12-3(5-Methylpyrazine-2,3-dicarbonitrile)
• 64535-52-0(Pyrazino[2,3-b]pyrazine-2,3,6,7-tetracarbonitrile)
• 19847-12-2(pyrazine-2-carbonitrile)
• 1122-28-7(4,5-Dicyanoimidazole)
• 65735-15-1(3-methylpyrazine-2-carbonitrile)
• 108257-41-6(5-Methylimidazole-4-carbonitrile)
• 2435-47-4(3,6-Dimethylpyrazine-2-carbonitrile)
• 861554-17-8(2,5-Pyrazinedicarbonitrile,3,6-dimethyl-)
• 33420-37-0(Pyrazine-2,3,5,6-tetracarbonitrile)