Production Method 1

21190-88-5

97483-79-9

Reaction Conditions

1.1 Solvents: Pyridine ;  rt; rt → reflux; 16 h, reflux

Reference

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Wang, Yansong; Kirschner, Alexander; Fabian, Anne-Katrin; Gopalakrishnan, Ranganath; Kress, Christoph; et al, Journal of Medicinal Chemistry, 2013, 56(10), 3922-3935

Production Method 2

97483-79-9

Reaction Conditions

Reference

Bicyclic aza-amides for treatment of psychiatric disorders

, United States, , ,

Production Method 3

21190-88-5

97483-79-9

Reaction Conditions

1.1 Reagents: Pyridine ;  6 h, reflux

Reference

Preparation of substituted phenylthiazole compounds as zinc-selective fluorescent probes for emission-ratiometric imaging

, World Intellectual Property Organization, , ,

Production Method 4

21190-88-5

97483-79-9

Reaction Conditions

1.1 Solvents: Pyridine ;  16 h, reflux

Reference

Preparation of bicyclic aza-amides for treatment of psychiatric disorders

, World Intellectual Property Organization, , ,

Production Method 5

30062-31-8

97483-79-9

Reaction Conditions

1.1 Reagents: Triethylamine ,  Trimethylsilyl cyanide Solvents: Acetonitrile

Reference

Site-selectivity in the cyanation of 3-substituted pyridine 1-oxides with trimethylsilanecarbonitrile

Sakamoto, Takao; Kaneda, Sohichi; Nishimura, Sumiko; Yamanaka, Hiroshi, Chemical & Pharmaceutical Bulletin, 1985, 33(2), 565-71

Production Method 6

617-35-6

100-70-9

97483-79-9

58481-14-4

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Water
1.2 Reagents: Sulfuric acid ,  Ferrous sulfate Solvents: Dichloromethane ,  Water

Reference

Homolytic alkoxycarbonylation reactions in two-phase systems. 3. Introduction of a single carboxylic acid ester function into cyano- or (alkoxycarbonyl)-substituted N-heteroaromatics

Heinisch, Gottfried; Loetsch, Gerhard, Heterocycles, 1987, 26(3), 731-44

Ethyl 6-cyanopicolinate Raw materials

• Ethyl pyruvate
• Ethyl 6-Bromopicolinate
• 2-Pyridinecarboxylic acid, ethyl ester, 1-oxide
• pyridine-2-carbonitrile

Ethyl 6-cyanopicolinate Preparation Products

• Ethyl 6-cyanopicolinate (97483-79-9)
• 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester (58481-14-4)

• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555

• 937-19-9(Methyl 5-cyano-1H-pyrrole-2-carboxylate)
• 68436-49-7(3,6,9,12-Tetraoxa-18-azabicyclo[12.3.1]octadeca-1(18),14,16-triene-2,13-dione)
• 39640-51-2(Ethyl 6-methylpyridine-2-carboxylate)
• 15658-60-3(Diethyl 2,6-pyridinedicarboxylate)
• 84555-18-0(Cyanomethyl picolinate)
• 64379-58-4(3,6,9,12,15-Pentaoxa-21-azabicyclo[15.3.1]heneicosa-1(21),17,19-triene-2,16-dione)
• 21635-99-4(Ethyl5-cyano-1H-pyrrole-2-carboxylate)
• 2524-52-9(Ethyl picolinate)
• 21855-16-3(6-(ethoxycarbonyl)pyridine-2-carboxylic acid)
• 68436-52-2(3,6,9,12,15,18-Hexaoxa-24-azabicyclo[18.3.1]tetracosa-1(24),20,22-triene-2,19-dione)