Production Method 1

617-35-6

100-70-9

58481-14-4

97483-79-9

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Water
1.2 Reagents: Sulfuric acid ,  Ferrous sulfate Solvents: Dichloromethane ,  Water

Reference

Homolytic alkoxycarbonylation reactions in two-phase systems. 3. Introduction of a single carboxylic acid ester function into cyano- or (alkoxycarbonyl)-substituted N-heteroaromatics

Heinisch, Gottfried; Loetsch, Gerhard, Heterocycles, 1987, 26(3), 731-44

2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester Raw materials

• Ethyl pyruvate
• pyridine-2-carbonitrile

2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester Preparation Products

• Ethyl 6-cyanopicolinate (97483-79-9)
• 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester (58481-14-4)

• 1. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Recent Advances in the Research of 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester (CAS: 58481-14-4)

2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester (CAS: 58481-14-4) is a significant intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting kinase inhibition and other therapeutic applications. Recent studies have highlighted its role in the development of novel drug candidates, emphasizing its versatility and efficacy in medicinal chemistry. This research briefing aims to provide an overview of the latest findings related to this compound, focusing on its synthesis, applications, and potential therapeutic benefits.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers explored the use of 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester as a key intermediate in the synthesis of potent kinase inhibitors. The study demonstrated that this compound could be efficiently modified to produce derivatives with enhanced selectivity and potency against specific kinase targets. The findings suggest that 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester holds promise for the development of next-generation kinase inhibitors, particularly in oncology and inflammatory diseases.

Another recent investigation, detailed in the European Journal of Pharmaceutical Sciences, focused on the optimization of synthetic routes for 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester. The researchers developed a novel, high-yield synthesis method that reduces production costs and improves scalability. This advancement is expected to facilitate broader application of the compound in industrial-scale pharmaceutical manufacturing, addressing previous challenges related to cost and availability.

Furthermore, a 2024 study in Bioorganic & Medicinal Chemistry Letters highlighted the potential of 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester in the design of antiviral agents. The compound was utilized as a scaffold to develop derivatives with activity against RNA viruses, including SARS-CoV-2. The results indicated that certain derivatives exhibited significant antiviral activity, suggesting a new avenue for antiviral drug development.

In conclusion, recent research underscores the importance of 2-Cyano-4-pyridinecarboxylic Acid Ethyl Ester (CAS: 58481-14-4) as a versatile and valuable intermediate in pharmaceutical chemistry. Its applications span from kinase inhibitors to antiviral agents, demonstrating its broad utility. Continued exploration of its derivatives and synthetic methodologies is likely to yield further breakthroughs in drug discovery and development.

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