Production Method 1

623-47-2

617-35-6

82290-07-1

262293-82-3

Reaction Conditions

1.1 Catalysts: Silver triflate ,  2249872-40-8 Solvents: Methanol ;  18.5 h, 40 °C

Reference

Hydroalkoxylation of terminal and internal alkynes catalyzed by dinuclear gold(I) complexes with bridging Di(N-heterocyclic carbene) ligands

Marcheggiani, Elena; et al, Catalysts, 2020, 10(1),

Ethyl pyruvate Raw materials

• ethyl propiolate

Ethyl pyruvate Preparation Products

• Ethyl pyruvate (617-35-6)
• 3-Methoxypropenoic acid ethyl ester (82290-07-1)
• ETHYL 3,3-DIMETHOXYPROPANOATE (262293-82-3)

• 1. Synthesis of picolinates via a cooperative vinylogous anomeric-based oxidation using UiO-66(Zr)-N(CH2PO3H2)2 as a catalyst
  Saeed Babaee,Hassan Sepehrmansourie,Mahmoud Zarei,Mohammad Ali Zolfigol,Mojtaba Hosseinifard RSC Adv. 2023 13 22503
• 2. Asymmetric hydrogenation of α-ketoesters on the Pt(111) surface
  Poonam Sharma,Rakesh K. Sharma New J. Chem. 2016 40 9038
• 3. TiCl4-n-Bu3N-mediated cascade annulation of ketones with α-ketoesters: a facile synthesis of highly substituted fused γ-alkylidene-butenolides
  Megha N. Palange,Rajesh G. Gonnade,Ravindar Kontham Org. Biomol. Chem. 2019 17 5749
• 4. A DFT study on the NHC catalysed Michael addition of enols to α,β-unsaturated acyl-azoliums. A base catalysed C–C bond-formation step
  Luis R. Domingo,José A. Sáez,Manuel Arnó Org. Biomol. Chem. 2014 12 895
• 5. Synthesis of α-indolylacrylates as potential anticancer agents using a Br?nsted acid ionic liquid catalyst and the butyl acetate solvent
  Ahmed El-Harairy,Mennatallah Shaheen,Jun Li,Yuzhou Wu,Minghao Li,Yanlong Gu RSC Adv. 2020 10 13507

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Keto acids and derivatives Alpha-keto acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Ethyl pyruvate (CAS No. 617-35-6): A Versatile Compound in Modern Chemical and Pharmaceutical Research

Ethyl pyruvate, with the chemical formula C?H?O? and CAS number 617-35-6, is an ester derivative of pyruvic acid. This compound has garnered significant attention in the fields of chemical biology and pharmaceutical research due to its diverse biological activities and potential therapeutic applications. Its molecular structure, featuring a carboxylate ester group, makes it a valuable intermediate in synthetic chemistry and a promising candidate for drug development.

The ethyl pyruvate molecule is characterized by its high reactivity, which stems from the presence of both a polar carboxyl group and a nonpolar ethyl moiety. This dual functionality allows it to interact with various biological targets, making it a versatile tool in medicinal chemistry. Recent studies have highlighted its role in modulating cellular processes, particularly in the context of inflammation, neuroprotection, and metabolic disorders.

In recent years, research on ethyl pyruvate has expanded significantly, driven by its potential as an anti-inflammatory agent. Studies have demonstrated that ethyl pyruvate can inhibit the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β). This effect is attributed to its ability to modulate signaling pathways involved in inflammation, such as the nuclear factor kappa B (NF-κB) pathway. These findings have opened new avenues for the development of novel anti-inflammatory therapies.

Beyond its anti-inflammatory properties, ethyl pyruvate has shown promise in neuroprotective applications. Preclinical studies have indicated that it can protect against neuronal damage caused by oxidative stress and excitotoxicity. The compound's ability to scavenge reactive oxygen species (ROS) and reduce oxidative stress makes it a potential candidate for treating neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Furthermore, its role in enhancing mitochondrial function has been observed, which could be beneficial in maintaining neuronal health.

The metabolic profile of ethyl pyruvate is another area of active investigation. Pyruvate itself is a key intermediate in cellular respiration, and ethyl pyruvate can be metabolized to produce energy or incorporated into other metabolic pathways. Research has suggested that ethyl pyruvate can influence glucose homeostasis and improve insulin sensitivity, making it a potential therapeutic agent for diabetes mellitus. These findings highlight the compound's significance in metabolic research and its potential applications in managing metabolic disorders.

Synthetic chemistry approaches have also been explored to utilize ethyl pyruvate as a building block for more complex molecules. Its reactivity allows for facile modifications through esterification, hydrolysis, and condensation reactions. These synthetic strategies have enabled the development of novel derivatives with enhanced biological activity. For instance, modifications of the ethyl group or the carboxylate moiety have led to compounds with improved efficacy in various pharmacological assays.

The pharmacokinetic properties of ethyl pyruvate have been studied to optimize its delivery and efficacy. Research has shown that the compound exhibits good oral bioavailability and can cross the blood-brain barrier, making it suitable for central nervous system (CNS) applications. Additionally, its stability under physiological conditions ensures prolonged activity within biological systems. These characteristics make ethyl pyruvate an attractive candidate for clinical translation.

In conclusion, ethyl pyruvate (CAS No. 617-35-6) is a multifaceted compound with significant potential in chemical biology and pharmaceutical research. Its diverse biological activities, coupled with its synthetic versatility, make it a valuable tool for drug discovery and development. Ongoing research continues to uncover new applications for this compound, particularly in the areas of inflammation, neuroprotection, and metabolic disorders. As our understanding of its mechanisms of action evolves, ethyl pyruvate is poised to play an increasingly important role in modern medicine.

• 20279-44-1(Butyl 2-oxopropanoate)
• 99419-43-9(Propanoic acid, 2-oxo-,2-hydroxyethyl ester)
• 76849-54-2(tert-butyl 2-oxopropanoate)
• 53939-79-0(Propanoic acid, 2-oxo-, hexyl ester)
• 147506-78-3(Propanoic acid, 2-oxo-,1-methylpropyl ester)
• 108899-52-1(Propanoic acid, 2-oxo-, anhydride with acetic acid (9CI))
• 609-09-6(1,3-diethyl 2-oxopropanedioate)
• 923-11-5(Isopropyl 2-oxopropanoate)
• 79951-02-3((Pyruvoyloxy)acetic acid)
• 13051-48-4(Isobutyl pyruvate)